Home Amines 157810-81-6
157810-81-6,MFCD00920346
Catalog No.:AA001PNU

157810-81-6 | D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-, sulfate (1:1)

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500mg
≥98%
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$52.00   $36.00
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1g
≥98%
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5g
≥98%
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001PNU
Chemical Name:
D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-, sulfate (1:1)
CAS Number:
157810-81-6
Molecular Formula:
C36H49N5O8S
Molecular Weight:
711.8680
MDL Number:
MFCD00920346
SMILES:
OS(=O)(=O)O.O[C@H](CN1CCN(C[C@H]1C(=O)NC(C)(C)C)Cc1cccnc1)C[C@H](C(=O)N[C@@H]1[C@H](O)Cc2c1cccc2)Cc1ccccc1
NSC Number:
697197
Properties
Computed Properties
 
Complexity:
1030  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
50  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
12  

Downstream Synthesis Route

[1]Roche,Dominique;Greiner,Jacques;Aubertin,Anne-Marie;Vierling,Pierre[EuropeanJournalofMedicinalChemistry,2008,vol.43,#7,p.1506-1518]

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Journal: Biochemistry 20080115

Title: Acquired reactive perforating collagenosis induced by indinavir in 2 patients with HIV disease.

Journal: European journal of dermatology : EJD 20080101

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Journal: Pharmacotherapy 20080101

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Journal: Archives of virology 20080101

Title: Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience.

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Journal: Journal of neurovirology 20080101

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Journal: Acta poloniae pharmaceutica 20080101

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Journal: BMC complementary and alternative medicine 20080101

Title: A novel approach to the prediction of drug-drug interactions in humans based on the serum incubation method.

Journal: Drug metabolism and pharmacokinetics 20080101

Title: Comparison of model-based tests and selection strategies to detect genetic polymorphisms influencing pharmacokinetic parameters.

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Title: [Indinavir-associated tubulointerstitial renal disease].

Journal: Nephrologie & therapeutique 20071201

Title: The SAEM algorithm for group comparison tests in longitudinal data analysis based on non-linear mixed-effects model.

Journal: Statistics in medicine 20071130

Title: Population pharmacokinetic analysis of lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART.

Journal: European journal of clinical pharmacology 20071101

Title: Pharmacokinetics of two randomized trials evaluating the safety and efficacy of indinavir, saquinavir and lopinavir in combination with low-dose ritonavir: the MaxCmin1 and 2 trials.

Journal: Basic & clinical pharmacology & toxicology 20071101

Title: Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers.

Journal: AIDS (London, England) 20071018

Title: Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence.

Journal: Cell death and differentiation 20071001

Title: HIV antiretroviral drug combination induces endothelial mitochondrial dysfunction and reactive oxygen species production, but not apoptosis.

Journal: Toxicology and applied pharmacology 20071001

Title: Maintenance of indinavir by dose adjustment in HIV-1-infected patients with indinavir-related toxicity.

Journal: European journal of clinical pharmacology 20071001

Title: Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.

Journal: Bioorganic & medicinal chemistry letters 20071001

Title: Prevalence and factors associated with dry skin in HIV infection: the FRAM study.

Journal: AIDS (London, England) 20071001

Title: Antiretroviral drug dosing errors in HIV-infected patients undergoing hemodialysis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070915

Title: Minimal effect of MDR1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of indinavir in HIV-infected patients.

Journal: British journal of clinical pharmacology 20070901

Title: [Three patients with indinavir-related urolithiasis].

Journal: Nederlands tijdschrift voor geneeskunde 20070818

Title: Experience of indinavir/ritonavir 400/100 mg twice-daily highly active antiretroviral therapy-containing regimen in HIV-1-infected patients in Bamako, Mali: the NOGOMA Study.

Journal: Journal of acquired immune deficiency syndromes (1999) 20070801

Title: Central nervous system distribution kinetics of indinavir in rats.

Journal: The Journal of pharmacy and pharmacology 20070801

Title: Comparison of indinavir + ritonavir 600 + 100 mg vs. 400 + 100 mg BID combinations in HIV1-infected patients guided by therapeutic drug monitoring.

Journal: European journal of medical research 20070726

Title: [Rapid development of anemia in a HIV-positive patient with alpha-thalassemia after zidovudine therapy].

Journal: Mikrobiyoloji bulteni 20070701

Title: Bayesian network analysis of resistance pathways against HIV-1 protease inhibitors.

Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20070601

Title: Indinavir/ritonavir remains an important component of HAART for the treatment of HIV/AIDS, particularly in resource-limited settings.

Journal: Expert opinion on drug metabolism & toxicology 20070601

Title: Indinavir/low-dose ritonavir containing HAART in HIV-1 infected children has potent antiretroviral activity, but is associated with side effects and frequent discontinuation of treatment.

Journal: Infection 20070601

Title: Chronic renal failure among HIV-1-infected patients.

Journal: AIDS (London, England) 20070531

Title: A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS.

Journal: Neurology 20070529

Title: Nephrotoxicity of antiretroviral therapy in an HIV-infected patient.

Journal: Kidney international 20070501

Title: Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens.

Journal: Journal of acquired immune deficiency syndromes (1999) 20070501

Title: Indinavir: the forgotten HIV-protease inhibitor. Does it still have a role?

Journal: Expert opinion on pharmacotherapy 20070501

Title: Effects of antiretroviral therapy on tube-like network formation of human endothelial cells.

Journal: Biological & pharmaceutical bulletin 20070501

Title: Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070401

Title: An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

Title: Indinavir trough concentration as a determinant of early nephrolithiasis in HIV-1-infected adults.

Journal: Therapeutic drug monitoring 20070401

Title: High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications.

Journal: Journal of pharmaceutical and biomedical analysis 20070312

Title: Differential protein binding of indinavir and saquinavir in matched maternal and umbilical cord plasma.

Journal: British journal of clinical pharmacology 20070301

Title: [Indinavir stones].

Journal: Actas urologicas espanolas 20070301

Title: Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages.

Journal: Virology 20070205

Title: Improving data reliability using a non-compliance detection method versus using pharmacokinetic criteria.

Journal: Journal of pharmacokinetics and pharmacodynamics 20070201

Title: Less sensitive HIV-1 enzyme immunoassay as an adjuvant method for monitoring patients receiving antiretroviral therapy.

Journal: AIDS patient care and STDs 20070201

Title: HIV protease inhibitors selectively induce gene expression alterations associated with reduced calcium deposition in primary human osteoblasts.

Journal: AIDS research and human retroviruses 20070201

Title: Hair versus plasma concentrations as indicator of indinavir exposure in HIV-1-infected patients treated with indinavir/ritonavir combination.

Journal: AIDS (London, England) 20070102

Title: Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070101

Title: Influence of body temperature on indinavir crystallization under loop of Henle conditions.

Journal: The Journal of antimicrobial chemotherapy 20070101

Title: Urological management of indinavir-associated acute renal failure in HIV-positive patients.

Journal: International urology and nephrology 20070101

Title: Efficacy and plasma concentrations of indinavir when boosted with ritonavir in human immunodeficiency virus-infected Thai children.

Journal: The Pediatric infectious disease journal 20070101

Title: Antiviral activity of HIV type 1 protease inhibitors nelfinavir and indinavir in vivo is not influenced by P-glycoprotein activity on CD4+ T cells.

Journal: AIDS research and human retroviruses 20070101

Title: Lack of indinavir-associated nephrological complications in HIV-infected adults (predominantly women) with high indinavir plasma concentration in Abidjan, Côte d'Ivoire.

Journal: AIDS research and human retroviruses 20070101

Title: MSE with mass defect filtering for in vitro and in vivo metabolite identification.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Infant of 22 months of age with no anomalies born from a HCV- and HIV-infected mother under treatment with pegylated interferon, ribavirin and antiretroviral therapy during the first 16 weeks of pregnancy.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20070101

Title: Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes.

Journal: Antiviral therapy 20070101

Title: Efficacy, safety, and tolerability of long-term combination antiretroviral therapy in asymptomatic treatment-naïve adults with early HIV infection.

Journal: HIV clinical trials 20070101

Title: Validation of high-performance liquid chromatography methods for determination of zidovudine, stavudine, lamivudine and indinavir in human plasma.

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101

Title: Morphological and biochemical appraisal of the liver and renal effects of indinavir on rat pregnancy.

Journal: Clinical and experimental obstetrics & gynecology 20070101

Title: Relationships between drug exposure, changes in metabolic parameters and body fat in HIV-infected patients switched to a nucleoside sparing regimen.

Journal: Antiviral therapy 20070101

Title: Indinavir crystalluria.

Journal: Kidney international 20061201

Title: Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery.

Journal: Journal of leukocyte biology 20061101

Title: Secretory aspartyl peptidase activity from mycelia of the human fungal pathogen Fonsecaea pedrosoi: effect of HIV aspartyl proteolytic inhibitors.

Journal: Research in microbiology 20061101

Title: Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery.

Journal: Blood 20061015

Title: Insulin sensitivity is preserved despite disrupted endothelial function.

Journal: American journal of physiology. Endocrinology and metabolism 20061001

Title: Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation.

Journal: Clinical pharmacology and therapeutics 20061001

Title: Evaluation of an International Pharmacopoeia method for the analysis of indinavir sulfate by liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20060911

Title: Effectiveness of low-dose indinavir/ritonavir at 400/100 mg twice a day with 2 nucleoside reverse transcriptase inhibitors in nonnucleoside reverse transcriptase inhibitor-experienced HIV-infected patients in India: 1-year follow-up.

Journal: Journal of acquired immune deficiency syndromes (1999) 20060901

Title: Changes in body composition and mitochondrial nucleic acid content in patients switched from failed nucleoside analogue therapy to ritonavir-boosted indinavir and efavirenz.

Journal: The Journal of infectious diseases 20060901

Title: Pharmacodynamics of antiretroviral agents in HIV-1 infected patients: using viral dynamic models that incorporate drug susceptibility and adherence.

Journal: Journal of pharmacokinetics and pharmacodynamics 20060801

Title: Association of total bilirubin with indinavir and lopinavir plasma concentrations in HIV-infected patients receiving three different double-boosted dosing regimens.

Journal: The Journal of antimicrobial chemotherapy 20060801

Title: Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study.

Journal: Journal of acquired immune deficiency syndromes (1999) 20060801

Title: Role of P-glycoprotein in tissue uptake of indinavir in rat.

Journal: Life sciences 20060801

Title: Feasibility of weekly HIV drug delivery to enhance drug localization in lymphoid tissues based on pharmacokinetic models of lipid-associated indinavir.

Journal: Pharmaceutical research 20060801

Title: Effect of widely used combinations of antiretroviral therapy on liver CYP3A4 activity in HIV-infected patients.

Journal: British journal of clinical pharmacology 20060801

Title: [Central nervous system HIV-associated polyarteritis nodosa: long-term outcome].

Journal: La Revue de medecine interne 20060801

Title: Lack of in vivo correlation between indinavir and saquinavir exposure and cytochrome P450 3A phenotype as assessed with oral midazolam as a phenotype probe.

Journal: Pharmacotherapy 20060801

Title: Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes.

Journal: Alcoholism, clinical and experimental research 20060801

Title: Urinary NO3 excretion and renal failure in indinavir-treated patients.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060801

Title: High prevalence of indinavir-associated renal complications in Thai HIV-infected patients.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801

Title: Pharmacokinetics and tolerability of a combination of indinavir, lopinavir and ritonavir in multiply pretreated HIV-1 infected adults.

Journal: European journal of medical research 20060630

Title: Gated binding of ligands to HIV-1 protease: Brownian dynamics simulations in a coarse-grained model.

Journal: Biophysical journal 20060601

Title: The use of pharmacokinetically guided indinavir dose reductions in the management of indinavir-associated renal toxicity.

Journal: The Journal of antimicrobial chemotherapy 20060601

Title: Real-time nucleic acid sequence-based amplification assay to quantify changes in mitochondrial DNA concentrations in cell cultures and blood cells from HIV-infected patients receiving antiviral therapy.

Journal: Clinical chemistry 20060601

Title: Optimization of lipid-indinavir complexes for localization in lymphoid tissues of HIV-infected macaques.

Journal: Journal of acquired immune deficiency syndromes (1999) 20060601

Title: Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation.

Journal: Journal of molecular biology 20060519

Title: HIV protease inhibitor therapy reverses neutrophil apoptosis in AIDS patients by direct calpain inhibition.

Journal: Apoptosis : an international journal on programmed cell death 20060501

Title: Biological characterization of human immunodeficiency virus type 1 subtype C protease carrying indinavir drug-resistance mutations.

Journal: The Journal of general virology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir.

Journal: Pharmacogenetics and genomics 20060501

Title: Electrochemical methods for determination of the protease inhibitor indinavir sulfate in pharmaceuticals and human serum.

Journal: Die Pharmazie 20060501

Title: Antiretroviral medications associated with elevated blood pressure among patients receiving highly active antiretroviral therapy.

Journal: AIDS (London, England) 20060424

Title: Prevalence of the HIV-1 protease mutation I47A in clinical practice and association with lopinavir resistance.

Journal: AIDS (London, England) 20060424

Title: Maintenance of successful ritonavir-boosted indinavir and efavirenz therapy in an HIV-infected patient with tuberculosis.

Journal: AIDS (London, England) 20060424

Title: Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060415

Title: [Drug-induced renal calculi].

Journal: Annales d'urologie 20060401

Title: Indinavir-treated Cryptococcus neoformans promotes an efficient antifungal immune response in immunosuppressed hosts.

Journal: Medical mycology 20060301

Title: Simple and sensitive high-performance liquid chromatography method for the quantitation of indinavir in rat plasma and central nervous system.

Journal: Journal of separation science 20060301

Title: Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

Journal: Journal of medicinal chemistry 20060223

Title: LC-MS/MS determination of the HIV-1 protease inhibitor indinavir in brain and testis of mice.

Journal: Journal of pharmaceutical and biomedical analysis 20060213

Title: [Clinical trial comparing efficacy and safety of four highly active antiretroviral therapy (HAART) in antiretroviral-naive treatment with advanced HIV infection].

Journal: Revista clinica espanola 20060201

Title: Once-daily directly observed therapy lopinavir/ritonavir plus indinavir as a protease inhibitor-only salvage therapy in heavily pretreated HIV-1-infected patients: a pilot study.

Journal: AIDS (London, England) 20060102

Title: HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents.

Journal: The Journal of pharmacology and experimental therapeutics 20060101

Title: Low urine pH is associated with reduced indinavir crystalluria in indinavir-treated HIV-infected individuals.

Journal: Clinical nephrology 20060101

Title: Effects of indinavir in a preliminary phase I study on dogs with stage III slenic hemangiosarcoma.

Journal: In vivo (Athens, Greece) 20060101

Title: Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro.

Journal: Basic & clinical pharmacology & toxicology 20060101

Title: T-cell line for HIV drug screening using EGFP as a quantitative marker of HIV-1 replication.

Journal: BioTechniques 20060101

Title: Adhesive capsulitis of the shoulder in human immunodeficiency virus-positive patients during highly active antiretroviral therapy.

Journal: Journal of shoulder and elbow surgery 20060101

Title: Boosted versus unboosted indinavir with zidovudine and lamivudine in nucleoside pre-treated patients: a randomized, open-label trial with 112 weeks of follow-up (HIV-NAT 005).

Journal: Antiviral therapy 20060101

Title: Incidence of and risk factors for insulin resistance in treatment-naive HIV-infected patients 48 weeks after starting highly active antiretroviral therapy.

Journal: Antiviral therapy 20060101

Title: [Pneumocystis jirovecii pneumonia: an old disease with a new name].

Journal: Medicina (Kaunas, Lithuania) 20060101

Title: Investigation of baseline susceptibility to protease inhibitors in HIV-1 subtypes C, F, G and CRF02_AG.

Journal: Antiviral therapy 20060101

Title: Quantitative SNP-detection method for estimating HIV-1 replicative fitness: application to protease inhibitor-resistant viruses.

Journal: Microbiology and immunology 20060101

Title: Performance of six different ritonavir-boosted protease inhibitor-based regimens in heavily antiretroviral-experienced HIV-infected patients.

Journal: HIV clinical trials 20060101

Title: An immunological comparison of third companion in advanced drug-naive HIV-infected patients.

Journal: HIV clinical trials 20060101

Title: Lamivudine and indinavir/ritonavir maintenance therapy in highly pretreated HIV-infected patients (Vista ANRS 109).

Journal: Antiviral therapy 20060101

Title: Absence of association between MDR1 genetic polymorphisms, indinavir pharmacokinetics and response to highly active antiretroviral therapy.

Journal: AIDS (London, England) 20051202

Title: Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.

Journal: Bioorganic & medicinal chemistry letters 20051201

Title: Steady-state pharmacokinetics and tolerability of indinavir-lopinavir/r combination therapy in antiretroviral-experienced patients.

Journal: Therapeutic drug monitoring 20051201

Title: Possible reduction in indinavir serum concentrations by bosentan.

Journal: Therapeutic drug monitoring 20051201

Title: Co-treatment with grapefruit juice inhibits while chronic administration activates intestinal P-glycoprotein-mediated drug efflux.

Journal: Die Pharmazie 20051201

Title: In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101

Title: Tissue distribution of indinavir administered as solid lipid nanocapsule formulation in mdr1a (+/+) and mdr1a (-/-) CF-1 mice.

Journal: Pharmaceutical research 20051101

Title: Indinavir/ritonavir 800/100 mg bid and efavirenz 600 mg qd in patients failing treatment with combination nucleoside reverse transcriptase inhibitors: 96-week outcomes of HIV-NAT 009.

Journal: HIV medicine 20051101

Title: Indinavir impairs endothelial function in healthy HIV-negative men.

Journal: American heart journal 20051101

Title: HIV protease inhibitors block adipocyte differentiation independently of lamin A/C.

Journal: AIDS (London, England) 20051014

Title: Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.

Journal: The FEBS journal 20051001

Title: Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050915

Title: Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle.

Journal: American journal of physiology. Endocrinology and metabolism 20050901

Title: Population pharmacokinetics of indinavir alone and in combination with ritonavir in HIV-1-infected patients.

Journal: British journal of clinical pharmacology 20050901

Title: Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050901

Title: GLUT4 facilitative glucose transporter specifically and differentially contributes to agonist-induced vascular reactivity in mouse aorta.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050801

Title: TDM: therapeutic drug measuring or therapeutic drug monitoring?

Journal: Therapeutic drug monitoring 20050801

Title: Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers.

Journal: Clinical pharmacology and therapeutics 20050801

Title: Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis.

Journal: The Journal of investigative dermatology 20050801

Title: HIV associated arthritis: case report and review of the literature.

Journal: European journal of medical research 20050729

Title: Antileishmanial activity of HIV protease inhibitors.

Journal: International journal of antimicrobial agents 20050701

Title: Indinavir protein-free concentrations when used in indinavir/ritonavir combination therapy.

Journal: AIDS (London, England) 20050701

Title: Effects on immunological and virological outcome of patients using one protease inhibitor or one non-nucleoside reverse transcriptase inhibitor in a triple antiretroviral therapy: normal clinical practice versus clinical trial findings.

Journal: Current HIV research 20050701

Title: Predicting drug metabolism--an evaluation of the expert system METEOR.

Journal: Chemistry & biodiversity 20050701

Title: [Consequences of replacing abacavir for indinavir in successful antiretroviral treatment of a patient with HIV infection].

Journal: Presse medicale (Paris, France : 1983) 20050604

Title: [Outcome of HIV-infected patients after 5 years of antiretroviral therapy including a protease inhibitor: the Aproco/Copilote Cohort].

Journal: Presse medicale (Paris, France : 1983) 20050604

Title: Highly active antiretroviral therapy and human immunodeficiency virus encephalitis.

Journal: Annals of neurology 20050601

Title: Low-doses of indinavir boosted with ritonavir in HIV-infected Thai patients: pharmacokinetics, efficacy and tolerability.

Journal: The Journal of antimicrobial chemotherapy 20050601

Title: Incidence of pancreatitis in HIV-1-infected individuals enrolled in 20 adult AIDS clinical trials group studies: lessons learned.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050601

Title: Population pharmacokinetic analysis of indinavir in HIV-infected patient treated with a stable antiretroviral therapy.

Journal: Fundamental & clinical pharmacology 20050601

Title: Genotypic resistance analyses in nucleoside-pretreated patients failing an indinavir containing regimen: results from a randomized comparative trial: (Novavir ANRS 073).

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20050601

Title: Evolution of resistance mutations pattern in HIV-1-infected patients during intensification therapy with a boosted protease inhibitor.

Journal: AIDS (London, England) 20050520

Title: Hepatotoxicity and nelfinavir: a meta-analysis.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20050501

Title: Switch from ritonavir to indinavir in combination therapy for HIV-1-infected children.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050415

Title: A pilot, double-blind, placebo-controlled trial of indinavir in patients with ALS.

Journal: Neurology 20050412

Title: Pharmacokinetic interaction between chemotherapy for non-Hodgkin's lymphoma and protease inhibitors in HIV-1-infected patients.

Journal: The Journal of antimicrobial chemotherapy 20050401

Title: Postexposure prophylaxis after sexual assaults: a prospective cohort study.

Journal: Sexually transmitted diseases 20050401

Title: Simple and simultaneous determination of the hiv-protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir plus M8 nelfinavir metabolite and the nonnucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma by reversed-phase liquid chromatography.

Journal: Therapeutic drug monitoring 20050401

Title: Investigation of oral bioavailability and brain distribution of the Ind(8)-Val conjugate of indinavir in rodents.

Journal: The Journal of pharmacy and pharmacology 20050401

Title: Virtual screening of HIV-1 protease inhibitors against human cytomegalovirus protease using docking and molecular dynamics.

Journal: AIDS (London, England) 20050325

Title: Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis.

Journal: European journal of clinical pharmacology 20050301

Title: Contribution of cellular HIV-1 DNA quantification to the efficacy analysis of antiretroviral therapy: a randomized comparison of 2 regimens, including 3 drugs from 2 or 3 classes (TRIANON, ANRS 081).

Journal: Journal of acquired immune deficiency syndromes (1999) 20050301

Title: Comparable pharmacokinetics of generic indinavir (Inhibisam) versus brand indinavir (Crixivan) when boosted with ritonavir.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050301

Title: Pharmacokinetic interaction study of indinavir/ritonavir and the enteric-coated capsule formulation of didanosine in healthy volunteers.

Journal: Journal of clinical pharmacology 20050201

Title: Indinavir plasma concentration and adherence score are codeterminant of early virologic response in HIV-infected patients of the APROCO cohort.

Journal: Therapeutic drug monitoring 20050201

Title: Dose reduction for the management of indinavir-related toxicity in human immunodeficiency virus type 1-infected patients in Taiwan: clinical and pharmacokinetic assessment.

Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20050201

Title: Warning about indinavir and pregnancy.

Journal: AIDS patient care and STDs 20050201

Title: Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers.

Journal: Pharmacotherapy 20050201

Title: Influence of indinavir on virulence and growth of Cryptococcus neoformans.

Journal: The Journal of infectious diseases 20050115

Title: Antiretroviral drug pharmacokinetics in hepatitis with hepatic dysfunction.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050101

Title: HIV type 1 protease inhibitors enhance bone marrow progenitor cell activity in normal subjects and in HIV type 1-infected patients.

Journal: AIDS research and human retroviruses 20050101

Title: Indinavir/ritonavir-based therapy in HIV-1-infected antiretroviral therapy-naive patients: comparison of 800/100 mg and 400/100 mg twice daily.

Journal: HIV medicine 20050101

Title: [Radio-opaque lithiasis and indinavir].

Journal: Actas urologicas espanolas 20050101

Title: Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors.

Journal: Antiviral therapy 20050101

Title: Pharmacokinetics of reduced-dose indinavir/ritonavir 400/100 mg twice daily in HIV-1-infected Thai patients.

Journal: Antiviral therapy 20050101

Title: The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life.

Journal: Health and quality of life outcomes 20050101

Title: Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: HIV protease inhibitors prevent mitochondrial hyperpolarization and redox imbalance and decrease endogenous uncoupler protein-2 expression in gp 120-activated human T lymphocytes.

Journal: Antiviral therapy 20050101

Title: High variability of indinavir and nelfinavir pharmacokinetics in HIV-infected patients with a sustained virological response on highly active antiretroviral therapy.

Journal: Clinical pharmacokinetics 20050101

Title: Efficacy and safety of indinavir/ritonavir 400/100 mg twice daily plus two nucleoside analogues in treatment-naive HIV-1-infected patients with CD4+ T-cell counts <200 cells/mm3: 96-week outcomes.

Journal: Antiviral therapy 20050101

Title: A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity.

Journal: The Journal of biological chemistry 20041231

Title: Fatal inflammatory AIDS-associated PML with high CD4 counts on HAART: a new clinical entity?

Journal: Neurology 20041228

Title: A comparison of dyslipidemias associated with either lopinavir/ritonavir- or indinavir/ritonavir-based antiretroviral therapy.

Journal: Journal of acquired immune deficiency syndromes (1999) 20041215

Title: C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s.

Journal: AIDS (London, England) 20041203

Title: Antiretrovirals as antimalarial agents.

Journal: The Journal of infectious diseases 20041201

Title: Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells.

Journal: The Journal of endocrinology 20041201

Title: Molecular dynamics simulations of 14 HIV protease mutants in complexes with indinavir.

Journal: Journal of molecular modeling 20041201

Title: Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats.

Journal: Die Pharmazie 20041201

Title: Health-related quality of life in HIV patients switching to twice-daily indinavir/ritonavir regimen or continuing with three-times-daily indinavir-based therapy.

Journal: Antiviral therapy 20041201

Title: Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial.

Journal: Clinical therapeutics 20041201

Title: Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir.

Journal: AIDS (London, England) 20041119

Title: Residual analysis in linear regression models with an interval-censored covariate.

Journal: Statistics in medicine 20041115

Title: Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes.

Journal: American journal of physiology. Cell physiology 20041101

Title: Efficiency of a second-generation HIV-1 protease inhibitor studied by molecular dynamics and absolute binding free energy calculations.

Journal: Proteins 20041101

Title: Comparison of two indinavir/ritonavir regimens in the treatment of HIV-infected individuals.

Journal: Journal of acquired immune deficiency syndromes (1999) 20041101

Title: Optimization and statistical evaluation of dissolution tests for indinavir sulfate capsules.

Journal: Farmaco (Societa chimica italiana : 1989) 20041101

Title: Persistent HIV type 1 infection in semen and blood compartments in patients after long-term potent antiretroviral therapy.

Journal: AIDS research and human retroviruses 20041101

Title: Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells.

Journal: The Journal of infectious diseases 20041015

Title: Pseudoaneurysm of the femoral artery in a HIV-infected man.

Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20041001

Title: The human immunodeficiency virus (HIV) protease inhibitor indinavir directly affects the opportunistic fungal pathogen Cryptococcus neoformans.

Journal: FEMS immunology and medical microbiology 20041001

Title: Antiretroviral protease inhibitors prevent l6 muscle cell fusion by reducing calpain activity.

Journal: AIDS research and human retroviruses 20041001

Title: Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.

Journal: Biochemistry 20040928

Title: P1' oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1.

Journal: Bioorganic & medicinal chemistry letters 20040920

Title: Indinavir increases glucose production in healthy HIV-negative men.

Journal: AIDS (London, England) 20040903

Title: Lopinavir/ritonavir- and indinavir-induced thrombocytopenia in a patient with HIV infection.

Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20040901

Title: The ICH guidance in practice: stress degradation studies on indinavir sulphate and development of a validated specific stability-indicating HPTLC assay method.

Journal: Farmaco (Societa chimica italiana : 1989) 20040901

Title: In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.

Journal: Journal of cellular biochemistry 20040815

Title: HIV-1 drug resistance in subjects with advanced HIV-1 infection in whom antiretroviral combination therapy is failing: a substudy of AIDS Clinical Trials Group Protocol 388.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040815

Title: Development of a microtiter plate fluorescent assay for inhibition studies on the HTLV-1 and HIV-1 proteinases.

Journal: Journal of virological methods 20040801

Title: Lopinavir/ritonavir combined with twice-daily 400 mg indinavir: pharmacokinetics and pharmacodynamics in blood, CSF and semen.

Journal: The Journal of antimicrobial chemotherapy 20040801

Title: Lipid lowering therapy with fluvastatin and pravastatin in patients with HIV infection and antiretroviral therapy: comparison of efficacy and interaction with indinavir.

Journal: Infection 20040801

Title: Impact of indinavir on the quality of life in patients with advanced HIV infection treated with zidovudine and lamivudine.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040801

Title: Maternal-fetal transfer and amniotic fluid accumulation of protease inhibitors in pregnant women who are infected with human immunodeficiency virus.

Journal: American journal of obstetrics and gynecology 20040801

Title: ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages.

Journal: Antiviral therapy 20040801

Title: [Drug-induced lithiasis].

Journal: Revue medicale de la Suisse romande 20040801

Title: Nail, hair and skin hyperpigmentation associated with indinavir therapy.

Journal: AIDS (London, England) 20040723

Title: The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling.

Journal: The Journal of clinical investigation 20040715

Title: Incidence of and risk factors for adverse drug reactions in a prospective cohort of HIV-infected adults initiating protease inhibitor-containing therapy.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040715

Title: Reversed-phase liquid chromatography with ultraviolet detection for simultaneous quantitation of indinavir and propranolol from ex-vivo rat intestinal permeability studies.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705

Title: HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2).

Journal: The Journal of pharmacology and experimental therapeutics 20040701

Title: Determination of indinavir and nelfinavir trough plasma concentration efficacy thresholds according to virological response in HIV-infected patients.

Journal: HIV medicine 20040701

Title: Thrombosis and a hypercoagulable state in HIV-infected patients.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20040701

Title: Triple nucleoside treatment with abacavir plus the lamivudine/zidovudine combination tablet (COM) compared to indinavir/COM in antiretroviral therapy-naïve adults: results of a 48-week open-label, equivalence trial (CNA3014).

Journal: Current medical research and opinion 20040701

Title: Predictors of adherence and virologic outcome in HIV-infected patients treated with abacavir- or indinavir-based triple combination HAART also containing lamivudine/zidovudine.

Journal: Current medical research and opinion 20040701

Title: Direct interference of HIV protease inhibitors with pancreatic beta-cell function.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040601

Title: The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients.

Journal: Antiviral therapy 20040601

Title: [Highly Active AntiRetroviral Therapy and cryptosporidiosis].

Journal: Parassitologia 20040601

Title: HIV protease inhibitors increase adiponectin levels in HIV-negative men.

Journal: Journal of acquired immune deficiency syndromes (1999) 20040501

Title: Involvement of P-glycoprotein in the transport of saquinavir and indinavir in rat brain microvessel endothelial and microglia cell lines.

Journal: Pharmaceutical research 20040501

Title: Ritonavir boosted indinavir treatment as a simplified maintenance 'mono'-therapy for HIV infection.

Journal: AIDS (London, England) 20040409

Title: Lopinavir/ritonavir vs. indinavir/ritonavir in antiretroviral naive HIV-infected patients: immunovirological outcome and side effects.

Journal: Antiviral research 20040401

Title: Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site.

Journal: European journal of biochemistry 20040401

Title: Comparison of two reduced-dose regimens of indinavir (600 mg vs 400 mg twice daily) and ritonavir (100 mg twice daily) in healthy volunteers (COREDIR).

Journal: Antiviral therapy 20040401

Title: Lamivudine 300 mg in HIV infection: dose change. Once-a-day dosing.

Journal: Prescrire international 20040401

Title: Effect of indinavir used alone or in double or triple combination with AZT and ddC on human immune functions.

Journal: Life sciences 20040319

Title: Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles?

Journal: The Journal of infectious diseases 20040315

Title: Detection of drug-resistant minority variants of HIV-1 during virologic failure of indinavir, lamivudine, and zidovudine.

Journal: The Journal of infectious diseases 20040315

Title: Indinavir and rifabutin drug interactions in healthy volunteers.

Journal: Journal of clinical pharmacology 20040301

Title: Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301

Title: Virological and immunological outcomes in HIV-1-infected Chinese patients treated with a combination of Efavirenz and Indinavir for 48 weeks.

Journal: Chinese medical journal 20040301

Title: Spectrophotometric determination of indinavir in bulk and pharmaceutical formulations using bromocresol purple and bromothymol blue.

Journal: Die Pharmazie 20040301

Title: Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors.

Journal: Journal of acquired immune deficiency syndromes (1999) 20040301

Title: Buffalo hump: what the experts suggest.

Journal: AIDS clinical care 20040301

Title: Efficacy of two modalities of triple HIV therapy: probable superiority of indinavir.

Journal: International journal of antimicrobial agents 20040301

Title: Chemokine mRNA levels in mononucleated cells of HIV-infected patients before and after initiation of PI- versus NNRTI-containing HAART.

Journal: Antiviral research 20040301

Title: The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma.

Journal: International journal of cancer 20040210

Title: Prodrugs of HIV protease inhibitors-saquinavir, indinavir and nelfinavir-derived from diglycerides or amino acids: synthesis, stability and anti-HIV activity.

Journal: Organic & biomolecular chemistry 20040207

Title: Capillary electrophoretic method for determination of protease inhibitor indinavir sulfate used in human immunodeficiency virus therapy.

Journal: Journal of pharmaceutical and biomedical analysis 20040204

Title: Anti-HIV drugs decrease the expression of matrix metalloproteinases in astrocytes and microglia.

Journal: Brain : a journal of neurology 20040201

Title: Pharmacokinetic interaction between rifampin and the combination of indinavir and low-dose ritonavir in HIV-infected patients.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040201

Title: Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir.

Journal: Analytical chemistry 20040201

Title: [Indinavir urolithiasis in HIV-positive patients. Treatment and prophylaxis].

Journal: Der Urologe. Ausg. A 20040201

Title: Strategies to decrease viral load rebound, and prevent loss of CD4 and onset of resistance during structured treatment interruptions.

Journal: Antiviral therapy 20040201

Title: IDV concentrations plummet with rifampicin.

Journal: IAPAC monthly 20040201

Title: Relapsing blepharitis in patients under highly active antiretroviral therapy including indinavir.

Journal: AIDS (London, England) 20040123

Title: Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7alpha-hydroxylase mRNA levels.

Journal: Biochemical pharmacology 20040115

Title: The effect of nevirapine on the pharmacokinetics of indinavir/ritonavir 800/100 mg BID.

Journal: Journal of acquired immune deficiency syndromes (1999) 20040101

Title: Risk factors and occurrence of rash in HIV-positive patients not receiving nonnucleoside reverse transcriptase inhibitor: data from a randomized study evaluating use of protease inhibitors in nucleoside-experienced patients with very low CD4 levels (<50 cells/microL).

Journal: HIV medicine 20040101

Title: Kinetic and thermodynamic characterization of HIV-1 protease inhibitors.

Journal: Journal of molecular recognition : JMR 20040101

Title: Peptidomimetic inhibitors of HIV protease.

Journal: Current topics in medicinal chemistry 20040101

Title: Pharmacokinetics of indinavir in Koreans and Caucasians.

Journal: Scandinavian journal of infectious diseases 20040101

Title: Urologic problems in patients with acquired immunodeficiency syndrome.

Journal: TheScientificWorldJournal 20040101

Title: Effects of HIV drug combinations on endothelin-1 and vascular cell proliferation.

Journal: Cardiovascular toxicology 20040101

Title: Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy.

Journal: Cardiovascular toxicology 20040101

Title: [Indinavir and renal lithiasis].

Journal: Actas urologicas espanolas 20040101

Title: HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants.

Journal: Cardiovascular toxicology 20040101

Title: Urolithiasis associated with indinavir in a patient with spinal cord injury.

Journal: The journal of spinal cord medicine 20040101

Title: HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis.

Journal: Cardiovascular toxicology 20040101

Title: Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N.

Journal: Biochemistry 20031230

Title: Shape signatures: a new approach to computer-aided ligand- and receptor-based drug design.

Journal: Journal of medicinal chemistry 20031218

Title: Plasma levels of indinavir and nelfinavir at time of virologic response may have a different impact on the risk of further virologic failure in HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20031215

Title: TMC125 exerts similar initial antiviral potency as a five-drug, triple class antiretroviral regimen.

Journal: AIDS (London, England) 20031205

Title: Lipid-drug association enhanced HIV-1 protease inhibitor indinavir localization in lymphoid tissues and viral load reduction: a proof of concept study in HIV-2287-infected macaques.

Journal: Journal of acquired immune deficiency syndromes (1999) 20031201

Title: No clinically significant pharmacokinetic interactions between voriconazole and indinavir in healthy volunteers.

Journal: British journal of clinical pharmacology 20031201

Title: Clinical use of a simultaneous HPLC assay for indinavir, saquinavir, ritonavir and nelfinavir in children and adults.

Journal: Therapeutic drug monitoring 20031201

Title: Photophobia in a patient with high indinavir plasma concentrations.

Journal: Therapeutic drug monitoring 20031201

Title: A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir.

Journal: Antiviral therapy 20031201

Title: Efficacy and safety of ritonavir/indinavir 100/400 mg twice daily in combination with two nucleoside analogues in antiretroviral treatment-naive HIV-infected individuals.

Journal: Antiviral therapy 20031201

Title: HIV envelope gp120-mediated regulation of osteoclastogenesis via receptor activator of nuclear factor kappa B ligand (RANKL) secretion and its modulation by certain HIV protease inhibitors through interferon-gamma/RANKL cross-talk.

Journal: The Journal of biological chemistry 20031128

Title: Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation.

Journal: AIDS (London, England) 20031121

Title: Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir.

Journal: Bioorganic & medicinal chemistry letters 20031117

Title: Resolution of HCV infection in a HIV-infected patient under HAART after several hepatitis flare-ups.

Journal: European journal of medical research 20031112

Title: Six-year follow-up of HIV-1-infected adults in a clinical trial of antiretroviral therapy with indinavir, zidovudine, and lamivudine.

Journal: AIDS (London, England) 20031107

Title: Influence of goldenseal root on the pharmacokinetics of indinavir.

Journal: Journal of clinical pharmacology 20031101

Title: Field evaluation of an improved assay using a heat-dissociated p24 antigen for adults mainly infected with HIV-1 CRF02_AG strains in Côte d'Ivoire, West Africa.

Journal: Journal of acquired immune deficiency syndromes (1999) 20031101

Title: Treating advanced HIV infection.

Journal: Journal of acquired immune deficiency syndromes (1999) 20031101

Title: The safety and efficacy of indinavir and ritonavir (400/400 mg BID) in HIV-1-infected individuals from an inner-city minority population: a pilot study.

Journal: International journal of STD & AIDS 20031101

Title: A 6-base pair insertion in the protease gene of HIV type 1 detected in a protease inhibitor-naive patient is not associated with indinavir treatment failure.

Journal: AIDS research and human retroviruses 20031101

Title: [A randomized clinical trial to compare the effectiveness of indinavir, ritonavir and saquinavir].

Journal: Medicina clinica 20031025

Title: Differential effect of HIV protease inhibitors on adipogenesis: intracellular ritonavir is not sufficient to inhibit differentiation.

Journal: AIDS (London, England) 20031017

Title: Long-term efficacy, safety, and tolerability of indinavir-based therapy in protease inhibitor-naive adults with advanced HIV infection.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031015

Title: Anti-apoptotic effect of HIV protease inhibitors via direct inhibition of calpain.

Journal: Biochemical pharmacology 20031015

Title: [Interaction between methadone and antiretrovirals (stavudine, indinavir, ritonavir, nevirapine)].

Journal: Medicina clinica 20031004

Title: Changes in indinavir exposure over time: a case study in six HIV-1-infected children.

Journal: The Journal of antimicrobial chemotherapy 20031001

Title: Analysis of the protease sequences of HIV-1 infected individuals after Indinavir monotherapy.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20031001

Title: Clinical use of a simultaneous HPLC assay for indinavir, saquinavir, ritonavir, and nelfinavir in children and adults.

Journal: Therapeutic drug monitoring 20031001

Title: Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells.

Journal: HIV medicine 20031001

Title: Pharmacokinetics of indinavir/ritonavir (800/100 mg) in combination with efavirenz (600 mg) in HIV-1-infected subjects.

Journal: Journal of acquired immune deficiency syndromes (1999) 20031001

Title: A once-daily HAART regimen containing indinavir + ritonavir plus one or two nucleoside reverse transcriptase inhibitors (PIPO study).

Journal: Antiviral therapy 20031001

Title: Anti-HIV agents. High-dose vitamin C may affect indinavir users.

Journal: TreatmentUpdate 20031001

Title: Efficacy of indinavir-ritonavir-based regimens in HIV-1-infected patients with prior protease inhibitor failures.

Journal: AIDS (London, England) 20030905

Title: Stavudine or indinavir-containing regimens are associated with an increased risk of diabetes mellitus in HIV-infected individuals.

Journal: AIDS (London, England) 20030905

Title: A randomized trial of 2 different 4-drug antiretroviral regimens versus a 3-drug regimen, in advanced human immunodeficiency virus disease.

Journal: The Journal of infectious diseases 20030901

Title: Randomized trial to evaluate indinavir/ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: the MaxCmin1 Trial.

Journal: The Journal of infectious diseases 20030901

Title: The HIV protease inhibitor indinavir reduces immature dendritic cell transendothelial migration.

Journal: European journal of immunology 20030901

Title: Factors associated with maintenance of long-term plasma human immunodeficiency virus RNA suppression.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030901

Title: The long-term effects of anti-retroviral protease inhibitors on sugar transport in L6 cells.

Journal: The Journal of endocrinology 20030901

Title: Overdose reports--an underutilized resource.

Journal: Pharmacoepidemiology and drug safety 20030901

Title: A five-year evaluation of reports of overdose with indinavir sulfate.

Journal: Pharmacoepidemiology and drug safety 20030901

Title: Boosted PIs: competition hots up.

Journal: The AIDS reader 20030901

Title: Characterizing classes of antiretroviral drugs by genotype.

Journal: Statistics in medicine 20030830

Title: Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial.

Journal: Annals of internal medicine 20030819

Title: Summaries for patients. Does marijuana affect viral loads in people with HIV?

Journal: Annals of internal medicine 20030819

Title: Virological rebound after suppression on highly active antiretroviral therapy.

Journal: AIDS (London, England) 20030815

Title: HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent.

Journal: Bioorganic & medicinal chemistry letters 20030804

Title: The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains.

Journal: Bioorganic & medicinal chemistry letters 20030804

Title: Push/pull mechanisms of GLUT4 traffic in muscle cells.

Journal: Acta physiologica Scandinavica 20030801

Title: Vasodilator agents protect against indinavir nephrotoxicity.

Journal: Antiviral therapy 20030801

Title: Administration of indinavir and low-dose ritonavir (800/100 mg twice daily) with food reduces nephrotoxic peak plasma levels of indinavir.

Journal: Antiviral therapy 20030801

Title: Sequential cutaneous drug reactions to protease inhibitors in the context of occupational post-exposure prophylaxis.

Journal: AIDS (London, England) 20030725

Title: Joint models for efficient estimation in proportional hazards regression models.

Journal: Statistics in medicine 20030715

Title: Indinavir reduces Cryptosporidium parvum infection in both in vitro and in vivo models.

Journal: International journal for parasitology 20030701

Title: HIV protease inhibitors acutely impair glucose-stimulated insulin release.

Journal: Diabetes 20030701

Title: Low-dose indinavir in combination with low-dose ritonavir: steady-state pharmacokinetics and long-term clinical outcome follow-up.

Journal: HIV medicine 20030701

Title: Coadministration of milk thistle and indinavir in healthy subjects.

Journal: Pharmacotherapy 20030701

Title: Antiretroviral therapy in HIV-2-infected patients: changes in plasma viral load, CD4+ cell counts, and drug resistance profiles of patients treated in Abidjan, Côte d'Ivoire.

Journal: AIDS (London, England) 20030701

Title: Mitochondrial membrane hyperpolarization hijacks activated T lymphocytes toward the apoptotic-prone phenotype: homeostatic mechanisms of HIV protease inhibitors.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030615

Title: A review of low-dose ritonavir in protease inhibitor combination therapy.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030615

Title: Latrogenic nephrogenic diabetes insipidus.

Journal: AIDS (London, England) 20030613

Title: Reverse phase high-performance liquid chromatography method for the analysis of amprenavir, efavirenz, indinavir, lopinavir, nelfinavir and its active metabolite (M8), ritonavir, and saquinavir in heparinized human plasma.

Journal: Therapeutic drug monitoring 20030601

Title: Simultaneous determination of the HIV drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite M8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography.

Journal: Therapeutic drug monitoring 20030601

Title: Cholelithiasis possibly induced by protease inhibitors in 3 patients.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030601

Title: Assessment of adherence to triple antiretroviral treatment including indinavir: role of the determination of plasma levels of indinavir.

Journal: Journal of acquired immune deficiency syndromes (1999) 20030601

Title: Interaction with indinavir to enhance systemic exposure of an investigational HIV protease inhibitor in rats, dogs and monkeys.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030601

Title: Indinavir plasma concentrations and resistance mutations in patients experiencing early virological failure.

Journal: AIDS research and human retroviruses 20030601

Title: Nucleoside-free regimen tested.

Journal: AIDS patient care and STDs 20030601

Title: Intracellular indinavir pharmacokinetics in HIV-infected patients: comparison with plasma pharmacokinetics.

Journal: Antiviral therapy 20030601

Title: Therapeutic drug monitoring of nelfinavir and indinavir in treatment-naive HIV-1-infected individuals.

Journal: AIDS (London, England) 20030523

Title: Suppression of cerebrospinal fluid HIV burden in antiretroviral naive patients on a potent four-drug antiretroviral regimen.

Journal: AIDS (London, England) 20030523

Title: Pharmacokinetics of nelfinavir and indinavir in HIV-1-infected pregnant women.

Journal: AIDS (London, England) 20030523

Title: A randomized trial to study first-line combination therapy with or without a protease inhibitor in HIV-1-infected patients.

Journal: AIDS (London, England) 20030502

Title: High indinavir plasma concentrations in HIV-positive patients co-infected with hepatitis B or C virus treated with low doses of indinavir and ritonavir (400/100 mg twice a day) plus two nucleoside reverse transcriptase inhibitors.

Journal: AIDS (London, England) 20030502

Title: Pharmacokinetics and pharmacodynamics of indinavir with or without low-dose ritonavir in HIV-infected Thai patients.

Journal: The Journal of antimicrobial chemotherapy 20030501

Title: Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues.

Journal: Diabetologia 20030501

Title: Differential effect of HIV-1 protease inhibitors on P-glycoprotein function in multidrug-resistant variants of the human CD4+ T lymphoblastoid CEM cell line.

Journal: Chemotherapy 20030501

Title: Factors associated with accelerated atherosclerosis in HIV-1-infected persons treated with protease inhibitors.

Journal: AIDS patient care and STDs 20030501

Title: [Observational study on the efficacy of the application of two classical regimens of triple antiretroviral therapy].

Journal: Anales de medicina interna (Madrid, Spain : 1984) 20030501

Title: In-vitro crystallization of indinavir in the presence of ritonavir and as a function of pH.

Journal: The Journal of pharmacy and pharmacology 20030501

Title: [Managing side effects. Individualized dosage makes indinavir more tolerable].

Journal: MMW Fortschritte der Medizin 20030428

Title: Changes in CSF and plasma HIV-1 RNA and cognition after starting potent antiretroviral therapy.

Journal: Neurology 20030422

Title: Continued indinavir versus switching to indinavir/ritonavir in HIV-infected patients with suppressed viral load.

Journal: AIDS (London, England) 20030411

Title: Sildenafil does not alter nelfinavir pharmacokinetics.

Journal: Therapeutic drug monitoring 20030401

Title: Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy.

Journal: The Journal of infectious diseases 20030401

Title: [Measuring the HIV viral load with LCx (Abbott): importance for the therapeutic follow-up of 3 patients infected by type O HIV].

Journal: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 20030401

Title: HIV-protease inhibitors impair vitamin D bioactivation to 1,25-dihydroxyvitamin D.

Journal: AIDS (London, England) 20030307

Title: Steady-state pharmacokinetic interaction of modified-dose indinavir and rifabutin.

Journal: Clinical pharmacology and therapeutics 20030301

Title: Indinavir-induced thrombocytopenia.

Journal: AIDS patient care and STDs 20030301

Title: Inference for a linear regression model with an interval-censored covariate.

Journal: Statistics in medicine 20030215

Title: Persistent leukocyturia and loss of renal function in a prospectively monitored cohort of HIV-infected patients treated with indinavir.

Journal: Journal of acquired immune deficiency syndromes (1999) 20030201

Title: Effect of indinavir on the intestinal exsorption of amprenavir, saquinavir and nelfinavir after intravenous administration in rats.

Journal: Biological & pharmaceutical bulletin 20030201

Title: The HIV protease inhibitor indinavir impairs glycogen synthesis in HepG2 hepatoma cells.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030201

Title: Protease inhibitor drug levels in the management of human immunodeficiency virus-1 antiretroviral therapy.

Journal: International journal of STD & AIDS 20030201

Title: [Antiretrovirals].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201

Title: Anti-retroviral protease inhibitors--'a two edged sword?'.

Journal: IUBMB life 20030201

Title: [HIV protease inhibitors for the treatment of Kaposi's sarcoma].

Journal: Recenti progressi in medicina 20030201

Title: A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.

Journal: Biochemistry 20030128

Title: Inhibition of TNF-alpha mediated cell death by HIV-1 specific protease inhibitors.

Journal: European journal of medical research 20030128

Title: Efficacy of a twice-daily antiretroviral regimen containing 100 mg ritonavir/400 mg indinavir in HIV-infected patients.

Journal: AIDS (London, England) 20030124

Title: Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors.

Journal: AIDS (London, England) 20030103

Title: Predicting HIV drug resistance with neural networks.

Journal: Bioinformatics (Oxford, England) 20030101

Title: The effects of protease inhibitors on basal and insulin-stimulated lipid metabolism, insulin binding, and signaling.

Journal: Journal of lipid research 20030101

Title: 'Multi-component reactions : emerging chemistry in drug discovery' 'from xylocain to crixivan'.

Journal: Current medicinal chemistry 20030101

Title: Overcoming resistance: virologic response to a salvage regimen with the combination of ritonavir plus indinavir.

Journal: HIV clinical trials 20030101

Title: Lipid changes in patients initiating efavirenz- and indinavir-based antiretroviral regimens.

Journal: HIV clinical trials 20030101

Title: Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors.

Journal: Journal of molecular recognition : JMR 20030101

Title: Indinavir did not further increase mean triglyceride levels in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors: an analysis of three randomized clinical trials.

Journal: Pharmacoepidemiology and drug safety 20030101

Title: Differences in durability of treatment with initial PI-based regimens.

Journal: HIV clinical trials 20030101

Title: Report from the 4th International Workshop on Clinical Pharmacology of HIV Therapy. Drinking lots of water still necessary with new indinavir regimens.

Journal: TreatmentUpdate 20030101

Title: Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine or stavudine, each in combination with lamivudine and indinavir.

Journal: Journal of acquired immune deficiency syndromes (1999) 20021215

Title: Open-label study of a twice-daily indinavir 800-mg/ritonavir 100-mg regimen in protease inhibitor-naive HIV-infected adults.

Journal: Journal of acquired immune deficiency syndromes (1999) 20021215

Title: Open-label study of a twice-daily indinavir 800-mg/ritonavir 200-mg regimen in HIV-infected adults failing a protease inhibitor regimen.

Journal: Journal of acquired immune deficiency syndromes (1999) 20021215

Title: Increased risk of lipoatrophy under stavudine in HIV-1-infected patients: results of a substudy from a comparative trial.

Journal: AIDS (London, England) 20021206

Title: Post-exposure prophylaxis.

Journal: International journal of STD & AIDS 20021201

Title: Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs.

Journal: AIDS (London, England) 20021122

Title: Underpowered clinical trials of antiretroviral treatment.

Journal: JAMA 20021106

Title: Nevirapine or lamivudine plus stavudine and indinavir: examples of 2-class versus 3-class regimens for the treatment of human immunodeficiency virus type 1.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021101

Title: Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy.

Journal: Diabetes 20021101

Title: Rapid assessment of phenotypic resistance to protease inhibitors in human immunodeficiency virus type 1 group O.

Journal: Journal of clinical microbiology 20021101

Title: Cutaneous EBV-related lymphoproliferative disorder in a 15-year-old boy with AIDS: an unusual clinical presentation.

Journal: Journal of pediatric hematology/oncology 20021101

Title: Transepithelial transport of prodrugs of the HIV protease inhibitors saquinavir, indinavir, and nelfinavir across Caco-2 cell monolayers.

Journal: Pharmaceutical research 20021101

Title: Experience of a combination including indinavir 400 mg plus ritonavir 200 mg twice daily in HIV-infected patients: pharmacokinetic data.

Journal: Pathologie-biologie 20021101

Title: Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.

Journal: Bioorganic & medicinal chemistry letters 20021021

Title: Risk factors for indinavir-related renal colic in HIV patients: predictive value of indinavir dose/body mass index.

Journal: AIDS (London, England) 20021018

Title: Rash-associated severe neutropenia as a side-effect of indinavir in HIV postexposure prophylaxis.

Journal: AIDS (London, England) 20021018

Title: Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20021018

Title: Simultaneous determination of five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20021015

Title: Relationship between levels of indinavir in hair and virologic response to highly active antiretroviral therapy.

Journal: Annals of internal medicine 20021015

Title: Hair it is: the long and short of monitoring antiretroviral treatment.

Journal: Annals of internal medicine 20021015

Title: Summaries for patients. The relationship between levels of the anti-HIV drug indinavir in patients' hair and response to treatment.

Journal: Annals of internal medicine 20021015

Title: Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics.

Journal: Journal of clinical pharmacology 20021001

Title: Rapid phenotypic assay for human immunodeficiency virus type 1 protease using in vitro translation.

Journal: Journal of virological methods 20021001

Title: Type B lactic acidosis: a rare complication of antiretroviral therapy after cardiac surgery.

Journal: The Annals of thoracic surgery 20021001

Title: Clinical lipoatrophy in HIV-1 patients on HAART is not associated with increased abdominal girth, hyperlipidaemia or glucose intolerance.

Journal: HIV medicine 20021001

Title: First-line ritonavir/indinavir 100/800 mg twice daily plus nucleoside reverse transcriptase inhibitors in a German multicentre study: 48-week results.

Journal: HIV medicine 20021001

Title: Indirect hyperbilirubinemia with indinavir.

Journal: The Journal of the Association of Physicians of India 20021001

Title: [Antiretroviral therapy with nelfinavir for patient infected, by HIV and secondary diabetes mellitus due to indinavir].

Journal: Medicina clinica 20020928

Title: Impact of HIV genotyping and drug levels on the response to salvage therapy with saquinavir/ritonavir.

Journal: AIDS (London, England) 20020927

Title: Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.

Journal: Bioorganic & medicinal chemistry letters 20020902

Title: Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains.

Journal: Bioorganic & medicinal chemistry letters 20020902

Title: Indinavir-induced cholelithiasis in a patient infected with human immunodeficiency virus.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020901

Title: Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.

Journal: Diabetes 20020901

Title: The unbound percentage of saquinavir and indinavir remains constant throughout the dosing interval in HIV positive subjects.

Journal: British journal of clinical pharmacology 20020901

Title: Trimethoprim-sulfamethoxazole (TMP/SMX) potentiates indinavir nephrotoxicity.

Journal: Antiviral therapy 20020901

Title: [HIV genotypic mutation selectively induced by the protease inhibitor nelfinavir at codon 30. Case series and consequences for antiretroviral management].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20020901

Title: Indinavir inhibits sterol-regulatory element-binding protein-1c-dependent lipoprotein lipase and fatty acid synthase gene activations.

Journal: AIDS (London, England) 20020816

Title: Generalized hair loss induced by indinavir plus ritonavir therapy.

Journal: AIDS (London, England) 20020816

Title: Simultaneous determination of indinavir, ritonavir and lopinavir (ABT 378) in human plasma by high-performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020805

Title: Pharmacokinetic evaluation of indinavir and indinavir/ritonavir-containing antiretroviral regimens in a clinical setting.

Journal: Therapeutic drug monitoring 20020801

Title: Persistent sterile leukocyturia is associated with impaired renal function in human immunodeficiency virus type 1-infected children treated with indinavir.

Journal: Pediatrics 20020801

Title: Engineering an indene bioconversion process for the production of cis-aminoindanol: a model system for the production of chiral synthons.

Journal: Applied microbiology and biotechnology 20020801

Title: Effect of coadministration of nelfinavir, indinavir, and saquinavir on the pharmacokinetics of amprenavir.

Journal: Clinical pharmacology and therapeutics 20020801

Title: Therapeutic drug monitoring of indinavir and nelfinavir to assess adherence to therapy in human immunodeficiency virus-infected children.

Journal: The Pediatric infectious disease journal 20020801

Title: Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial.

Journal: JAMA 20020710

Title: Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes.

Journal: Biochemistry 20020709

Title: Risk factors for urological symptoms in a cohort of users of the HIV protease inhibitor indinavir sulfate: the ATHENA cohort.

Journal: Archives of internal medicine 20020708

Title: Evolutionary analysis of HIV-1 protease inhibitors: Methods for design of inhibitors that evade resistance.

Journal: Proteins 20020701

Title: Virologic rebound on HAART in the context of low treatment adherence is associated with a low prevalence of antiretroviral drug resistance.

Journal: Journal of acquired immune deficiency syndromes (1999) 20020701

Title: Immunophenotypic analyses of CD34(+) cell subsets in bone marrow from HIV-infected patients during highly- active antiretroviral therapy.

Journal: European journal of clinical investigation 20020701

Title: High-performance liquid chromatographic method for the simultaneous determination of the six HIV-protease inhibitors and two non-nucleoside reverse transcriptase inhibitors in human plasma.

Journal: Therapeutic drug monitoring 20020601

Title: Urinary cytology associated with human polyomavirus and indinavir therapy in HIV-infected patients.

Journal: American journal of clinical pathology 20020601

Title: Adherence to antiretroviral therapy and outcomes in HIV-infected patients enrolled in an induction/maintenance randomized trial.

Journal: Antiviral therapy 20020601

Title: Select HIV protease inhibitors alter bone and fat metabolism ex vivo.

Journal: The Journal of biological chemistry 20020531

Title: A neutravidin-based assay for reverse transcriptase suitable for high throughput screening of retroviral activity.

Journal: Journal of biochemistry and molecular biology 20020531

Title: Intestinal metabolism promotes regional differences in apical uptake of indinavir: coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability in rat.

Journal: The Journal of pharmacology and experimental therapeutics 20020501

Title: Extrapyramidal symptoms with ritonavir/indinavir plus risperidone.

Journal: The Annals of pharmacotherapy 20020501

Title: Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers.

Journal: Pharmacotherapy 20020501

Title: Reversible posterior leukoencephalopathy secondary to indinavir-induced hypertensive crisis: a case report.

Journal: American journal of hypertension 20020501

Title: Male sexual dysfunction associated with antiretroviral therapy.

Journal: Journal of acquired immune deficiency syndromes (1999) 20020501

Title: Bone mineral density abnormalities in patients with HIV infection.

Journal: Journal of acquired immune deficiency syndromes (1999) 20020501

Title: [Ureteral lithiasis caused by Indinavir].

Journal: Revista medica de Chile 20020501

Title: Sarcoidosis and interstitial nephritis in a child with acquired immunodeficiency syndrome: implications of immune reconstitution syndrome with an indinavir-based regimen.

Journal: The Pediatric infectious disease journal 20020501

Title: AIDS-related primary central nervous system lymphoma: prolonged remission associated with highly active antiretroviral therapy.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20020501

Title: A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein.

Journal: Journal of medicinal chemistry 20020425

Title: Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findings.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020415

Title: Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations.

Journal: AIDS (London, England) 20020412

Title: HIV protease inhibitors and glucose metabolism.

Journal: AIDS (London, England) 20020412

Title: [A plea for an individualized therapy regimen. Which is the optimal dose?].

Journal: MMW Fortschritte der Medizin 20020409

Title: [More transparency facilities drug choice in general practice. Booster regimens in direct comparison].

Journal: MMW Fortschritte der Medizin 20020409

Title: Results of 2 years of treatment with protease-inhibitor--containing antiretroviral therapy in dutch children infected with human immunodeficiency virus type 1.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020401

Title: Simultaneous determination of the six HIV protease inhibitors (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir) plus M8 nelfinavir metabolite and the nonnucleoside reverse transcription inhibitor efavirenz in human plasma by solid-phase extraction and column liquid chromatography.

Journal: Therapeutic drug monitoring 20020401

Title: Indinavir induces acute and reversible peripheral insulin resistance in rats.

Journal: Diabetes 20020401

Title: High indinavir Cmin is associated with higher toxicity in patients on indinavir-ritonavir 800/100 mg twice-daily regimen.

Journal: Journal of acquired immune deficiency syndromes (1999) 20020401

Title: Low-dose ritonavir for protease inhibitor pharmacokinetic enhancement.

Journal: The Annals of pharmacotherapy 20020401

Title: CD4 response is correlated with peak plasma concentrations of indinavir in adults with undetectable human immunodeficiency virus ribonucleic acid.

Journal: Clinical pharmacology and therapeutics 20020401

Title: [Post-exposure prophylaxis in Zambia; the experiences of a tropical disease specialist following a cut accidentally incurred while operating on an HIV positive patient].

Journal: Nederlands tijdschrift voor geneeskunde 20020330

Title: The human 26S proteasome is a target of antiretroviral agents.

Journal: AIDS (London, England) 20020329

Title: Improved long-term suppression of HIV-1 replication with a triple-class multidrug regimen compared with standard of care antiretroviral therapy.

Journal: AIDS (London, England) 20020329

Title: The utility of inhibitory quotients in determining the relative potency of protease inhibitors.

Journal: AIDS (London, England) 20020329

Title: Osteosclerosis and periostal new bone formation during indinavir therapy.

Journal: AIDS (London, England) 20020329

Title: Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study.

Journal: AIDS (London, England) 20020329

Title: The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavir.

Journal: AIDS (London, England) 20020308

Title: Concentration-controlled compared with conventional antiretroviral therapy for HIV infection.

Journal: AIDS (London, England) 20020308

Title: Final analysis of the Trilège induction-maintenance trial: results at 18 months.

Journal: AIDS (London, England) 20020308

Title: Poor solubility limiting significance of in-vitro studies with HIV protease inhibitors.

Journal: AIDS (London, England) 20020308

Title: [Acute coronary syndromes in patients treated with HIV protease inhibitors].

Journal: Presse medicale (Paris, France : 1983) 20020302

Title: Complementary antiviral efficacy of hydroxyurea and protease inhibitors in human immunodeficiency virus-infected dendritic cells and lymphocytes.

Journal: Journal of virology 20020301

Title: HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma.

Journal: Nature medicine 20020301

Title: Characterizing the relationship between HIV-1 genotype and phenotype: prediction-based classification.

Journal: Biometrics 20020301

Title: A combinatorial library of indinavir analogues and its in vitro and in vivo studies.

Journal: Bioorganic & medicinal chemistry letters 20020225

Title: A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation.

Journal: Brain research 20020215

Title: Reduction of HIV-1 viral load in saliva by indinavir-containing antiretroviral regimen.

Journal: AIDS (London, England) 20020215

Title: Targeted delivery of indinavir to HIV-1 primary reservoirs with immunoliposomes.

Journal: Biochimica et biophysica acta 20020201

Title: Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.

Journal: Protein science : a publication of the Protein Society 20020201

Title: Treatment with highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children is associated with a sustained effect on growth.

Journal: Pediatrics 20020201

Title: In-vitro and in-vivo pharmacokinetic interactions of amprenavir, an HIV protease inhibitor, with other current HIV protease inhibitors in rats.

Journal: The Journal of pharmacy and pharmacology 20020201

Title: Efficacy of highly active antiretroviral therapy in HIV-1 infected children.

Journal: The Lancet. Infectious diseases 20020201

Title: [A clinical trial using zidovudine and lamivudine plus indinavir triple therapy in Chinese individuals with human immunodeficiency virus infection].

Journal: Zhonghua nei ke za zhi 20020201

Title: Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression.

Journal: AIDS (London, England) 20020125

Title: Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremia.

Journal: AIDS (London, England) 20020125

Title: Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease.

Journal: AIDS research and human retroviruses 20020120

Title: [Advances in the domain of HIV].

Journal: Presse medicale (Paris, France : 1983) 20020119

Title: Virological suppression at 6 months is related to choice of initial regimen in antiretroviral-naive patients: a cohort study.

Journal: AIDS (London, England) 20020104

Title: Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection.

Journal: The Journal of infectious diseases 20020101

Title: Rheumatological complications associated with the use of indinavir and other protease inhibitors.

Journal: Annals of the rheumatic diseases 20020101

Title: Pharmacokinetic variability caused by gender: do women have higher indinavir exposure than men?

Journal: Journal of acquired immune deficiency syndromes (1999) 20020101

Title: The HIV protease inhibitor saquinavir impairs lipid metabolism and glucose transport in cultured adipocytes.

Journal: The Journal of endocrinology 20020101

Title: Changing morbidity of cutaneous diseases in patients with HIV after the introduction of highly active antiretroviral therapy including a protease inhibitor.

Journal: American journal of clinical dermatology 20020101

Title: Differences in the detection of three HIV-1 protease inhibitors in non-blood compartments: clinical correlations.

Journal: HIV clinical trials 20020101

Title: The influence of efavirenz on the pharmacokinetics of a twice-daily combination of indinavir and low-dose ritonavir in healthy volunteers.

Journal: Clinical pharmacology and therapeutics 20020101

Title: CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020101

Title: Epidural lipomatosis secondary to indinavir in an HIV-positive patient.

Journal: Clinical neuropharmacology 20020101

Title: Therapeutic drug monitoring of indinavir in HIV-infected patients undergoing HAART.

Journal: Infection 20020101

Title: Interaction between levothyroxine and indinavir in a patient with HIV infection.

Journal: Infection 20020101

Title: HIV postexposure prophylaxis in the remote prehospital environment.

Journal: Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors 20020101

Title: The role of pharmacokinetics in drug discovery: finding drug candidates with the greatest potential for success.

Journal: Ernst Schering Research Foundation workshop 20020101

Title: Successful simplification of HAART in patients with acute primary HIV infection.

Journal: Journal of biological regulators and homeostatic agents 20020101

Title: Long-term efficacy and safety of ritonavir/indinavir at 400/400 mg twice a day in combination with two nucleoside reverse transcriptase inhibitors as first line antiretroviral therapy.

Journal: HIV medicine 20020101

Title: A critical evaluation of the therapeutic range of indinavir.

Journal: The Annals of pharmacotherapy 20020101

Title: Evaluation of the origins of the selectivity of polymers imprinted with a HIV protease inhibitor using infrared spectroscopy and high performance liquid chromatography.

Journal: Enantiomer 20020101

Title: Hepatic and intestinal contributions to pharmacokinetic interaction of indinavir with amprenavir, nelfinavir and saquinavir in rats.

Journal: Antiviral chemistry & chemotherapy 20020101

Title: Immune reconstitution during intensive chemotherapy in patients with human immunodeficiency virus related non-Hodgkin lymphoma.

Journal: The hematology journal : the official journal of the European Haematology Association 20020101

Title: [Prophylactic antiretroviral therapy after sexual exposure to HIV: 93 cases].

Journal: Annales de dermatologie et de venereologie 20020101

Title: Toxicity. Milk thistle and indinavir.

Journal: TreatmentUpdate 20020101

Title: Lamivudine 300 mg QD versus continued lamivudine 150 mg BID with stavudine and a protease inhibitor in suppressed patients.

Journal: HIV clinical trials 20020101

Title: Indinavir-induced retinoid-like effects: incidence, clinical features and management.

Journal: Drug safety 20020101

Title: [Drug-induced acute pancreatitis: a personal contribution].

Journal: Chirurgia italiana 20020101

Title: Intracellular concentration of protease inhibitors in HIV-1-infected patients: correlation with MDR-1 gene expression and low dose of ritonavir.

Journal: HIV clinical trials 20020101

Title: Treatment of indinavir sulfate induced urolithiasis in HIV-positive patients.

Journal: International urology and nephrology 20020101

Title: [Renal lithiasis due to indinavir].

Journal: Revista de medicina de la Universidad de Navarra 20020101

Title: Antiretroviral therapy 2002: old and new paradigms.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20020101

Title: Differential effects of HIV-1 protease inhibitors on dendritic cell immunophenotype and function.

Journal: The Journal of biological chemistry 20011221

Title: Predictors of virologic and clinical outcomes in HIV-1-infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine. AIDS Clinical Trials Group Protocol 320.

Journal: Annals of internal medicine 20011204

Title: Summaries for patients. Predictors of outcomes in patients with HIV infection treated with indinavir, zidovudine, and lamivudine.

Journal: Annals of internal medicine 20011204

Title: The chemotherapeutic agent bleomycin in a two-drug combination with zidovudine, ritonavir or indinavir synergistically inhibits HIV Type-1 replication in peripheral blood lymphocytes.

Journal: International journal of antimicrobial agents 20011201

Title: Reduction of signal suppression effects in ESI-MS using a nanosplitting device.

Journal: Analytical chemistry 20011201

Title: Has there been a decrease in the prevalence of mood disorders in HIV-seropositive individuals since the introduction of combination therapy?

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20011201

Title: [Urinary lithiasis secondary to indinavir in an HIV-positive patient].

Journal: Archivos espanoles de urologia 20011201

Title: Ritonavir/saquinavir plus one nucleoside reverse transcriptase inhibitor (NRTI) versus indinavir plus two NRTIs in protease inhibitor-naive HIV-1-infected adults (IRIS study).

Journal: Antiviral therapy 20011201

Title: Correlation between reduction in plasma HIV-1 RNA concentration 1 week after start of antiretroviral treatment and longer-term efficacy.

Journal: Lancet (London, England) 20011124

Title: Protease inhibitors and erectile dysfunction.

Journal: AIDS (London, England) 20011123

Title: HIV protease inhibitors reduce IL-2 release from normal human phytohaemagglutinin-activated T cells.

Journal: AIDS (London, England) 20011123

Title: Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir.

Journal: Carbohydrate research 20011121

Title: Synergistic antiadipogenic effects of HIV type 1 protease inhibitors with tumor necrosis factor alpha: suppression of extracellular insulin action mediated by extracellular matrix-degrading proteases.

Journal: AIDS research and human retroviruses 20011120

Title: Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo.

Journal: The Journal of infectious diseases 20011115

Title: Switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy.

Journal: The Journal of infectious diseases 20011101

Title: Naltrexone potentiates anti-HIV-1 activity of antiretroviral drugs in CD4+ lymphocyte cultures.

Journal: Drug and alcohol dependence 20011101

Title: Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice.

Journal: Laboratory investigation; a journal of technical methods and pathology 20011101

Title: Symptomatic hyperbilirubinemia with indinavir/ritonavir-containing regimen.

Journal: The Annals of pharmacotherapy 20011101

Title: Indinavir nephropathy revisited: a pattern of insidious renal failure with identifiable risk factors.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20011001

Title: Limited patient adherence to highly active antiretroviral therapy for HIV-1 infection in an observational cohort study.

Journal: Archives of internal medicine 20010910

Title: Drug resistance in patients experiencing early virological failure under a triple combination including indinavir.

Journal: AIDS (London, England) 20010907

Title: Indinavir-associated asymptomatic nephrolithiasis and renal cortex atrophy in two HIV-1 infected children.

Journal: AIDS (London, England) 20010907

Title: Antiretroviral drug concentrations in semen of HIV-infected men: differential penetration of indinavir, ritonavir and saquinavir.

Journal: The Journal of antimicrobial chemotherapy 20010901

Title: Incidence and risk factors for the development of indinavir-associated renal complications.

Journal: The Journal of antimicrobial chemotherapy 20010901

Title: Application of radiolabeled tracers to biocatalytic flux analysis.

Journal: European journal of biochemistry 20010901

Title: Indinavir crystallization around the loop of Henle: experimental evidence.

Journal: Journal of acquired immune deficiency syndromes (1999) 20010901

Title: Different combinations of ritonavir-indinavir.

Journal: TreatmentUpdate 20010901

Title: Drug resistance mutations in HIV-1-infected subjects during protease inhibitor-containing highly active antiretroviral therapy with nelfinavir or indinavir.

Journal: Antiviral therapy 20010901

Title: A case of flare syndrome.

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20010901

Title: Indinavir did not increase the short-term risk of adverse cardiovascular events relative to nucleoside reverse transcriptase inhibitor therapy in four phase III clinical trials.

Journal: AIDS (London, England) 20010817

Title: HIV-protease inhibitors contribute to P-glycoprotein efflux function defect in peripheral blood lymphocytes from HIV-positive patients receiving HAART.

Journal: Journal of acquired immune deficiency syndromes (1999) 20010801

Title: Asymmetric synthesis of chiral organofluorine compounds: use of nonracemic fluoroiodoacetic acid as a practical electrophile and its application to the synthesis of monofluoro hydroxyethylene dipeptide isosteres within a novel series of HIV protease inhibitors.

Journal: Journal of the American Chemical Society 20010801

Title: Antiretrovirals: simultaneous determination of five protease inhibitors and three nonnucleoside transcriptase inhibitors in human plasma by a rapid high-performance liquid chromatography--mass spectrometry assay.

Journal: Therapeutic drug monitoring 20010801

Title: Papillary necrosis associated with the HIV protease inhibitor indinavir.

Journal: Infection 20010801

Title: Antiretroviral rounds. When success is a pain.

Journal: AIDS clinical care 20010801

Title: [Paronychia in patients infected with HIV treated with indinavir].

Journal: Revista clinica espanola 20010801

Title: P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?

Journal: AIDS (London, England) 20010727

Title: Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression.

Journal: AIDS (London, England) 20010727

Title: Clinical assessment of HIV-associated lipodystrophy in an ambulatory population.

Journal: AIDS (London, England) 20010727

Title: Long-term protease inhibitor-containing therapy results in limited improvement in T cell function but not restoration of interleukin-12 production in pediatric patients with AIDS.

Journal: The Journal of infectious diseases 20010715

Title: The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals.

Journal: Blood 20010715

Title: High-performance liquid chromatographic assay to determine the plasma levels of HIV-protease inhibitors (amprenavir, indinavir, nelfinavir, ritonavir and saquinavir) and the non-nucleoside reverse transcriptase inhibitor (nevirapine) after liquid-liquid extraction.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010715

Title: Prevalence and predictive value of intermittent viremia with combination hiv therapy.

Journal: JAMA 20010711

Title: Stable or increasing bone mineral density in HIV-infected patients treated with nelfinavir or indinavir.

Journal: AIDS (London, England) 20010706

Title: P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: CMVR diagnoses and progression of CD4 cell counts and HIV viral load measurements in HIV patients on HAART.

Journal: The British journal of ophthalmology 20010701

Title: In vitro metabolism and drug interaction potential of a new highly potent anti-cytomegalovirus molecule, CMV423 (2-chloro 3-pyridine 3-yl 5,6,7,8-tetrahydroindolizine I-carboxamide).

Journal: British journal of clinical pharmacology 20010701

Title: A pilot trial of indinavir, ritonavir, didanosine, and lamivudine in a once-daily four-drug regimen for HIV infection.

Journal: Journal of acquired immune deficiency syndromes (1999) 20010701

Title: HIV protease inhibitors attenuate adherence of Candida albicans to epithelial cells in vitro.

Journal: FEMS immunology and medical microbiology 20010701

Title: Recent advances in the management and treatment of GI and hepatic diseases associated with HIV: Part I.

Journal: The AIDS reader 20010701

Title: Indinavir and bones: does thickness = strength?

Journal: TreatmentUpdate 20010701

Title: Simultaneous determination of the HIV-protease inhibitors indinavir, amprenavir, ritonavir, saquinavir and nelfinavir in human plasma by reversed-phase high-performance liquid chromatography.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010615

Title: Hypercholesterolemia in a health care worker receiving thyroxine after postexposure prophylaxis for human immunodeficiency virus infection.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010601

Title: The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance.

Journal: Diabetes 20010601

Title: The HIV protease inhibitor indinavir decreases insulin- and contraction-stimulated glucose transport in skeletal muscle.

Journal: Diabetes 20010601

Title: Prospective evaluation of the effect of initiating indinavir-based therapy on insulin sensitivity and B-cell function in HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20010601

Title: Limited sampling approach.

Journal: Clinical pharmacology and therapeutics 20010601

Title: The effects of antiretroviral protease inhibitors on serum lipid levels in HIV-infected patients.

Journal: Journal of the American Dietetic Association 20010601

Title: Once-a-day indinavir studied.

Journal: AIDS patient care and STDs 20010601

Title: Background on glucose--from food to blood sugar.

Journal: TreatmentUpdate 20010601

Title: Indinavir--effect on sugar and insulin.

Journal: TreatmentUpdate 20010601

Title: Protease inhibitors and blood sugar problems.

Journal: TreatmentUpdate 20010601

Title: Clinical outcome among HIV-infected patients starting saquinavir hard gel compared to ritonavir or indinavir.

Journal: AIDS (London, England) 20010525

Title: Sexual dysfunction associated with protease inhibitor containing highly active antiretroviral treatment.

Journal: AIDS (London, England) 20010525

Title: 'Do HIV-infected injecting drug users over-report adherence to highly active antiretroviral therapy?' A comparison between patients' self-reports and serum protease inhibitor concentrations in the French Manif 2000 cohort study.

Journal: AIDS (London, England) 20010525

Title: Low incidence of genotypic and phenotypic resistance in paediatric HIV-infected patients on long-term first-line antiretroviral triple therapy.

Journal: AIDS (London, England) 20010525

Title: Is indinavir crystalluria an indicator for indinavir stone formation?

Journal: AIDS (London, England) 20010525

Title: Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir and nelfinavir in human plasma by high-performance liquid chromatography.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010505

Title: [Effective in HIV: dual combination with indinavir and ritonavir].

Journal: Deutsche medizinische Wochenschrift (1946) 20010504

Title: Indinavir hair concentration in highly active antiretroviral therapy-treated patients: association with viral load and drug resistance.

Journal: AIDS (London, England) 20010504

Title: Metabolic effects of indinavir in healthy HIV-seronegative men.

Journal: AIDS (London, England) 20010504

Title: An LC-MS-MS method for the determination of indinavir, an HIV-1 protease inhibitor, in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20010501

Title: Residual human immunodeficiency virus (HIV) Type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years.

Journal: The Journal of infectious diseases 20010501

Title: Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.

Journal: Endocrinology 20010501

Title: Residual human immunodeficiency virus type 1 infection in lymphoid tissue during highly active antiretroviral therapy: quantitation and virus characterization.

Journal: AIDS research and human retroviruses 20010501

Title: [Indinavir-ritonavir combination: pharmacologic results and tolerance in patients infected by HIV].

Journal: Presse medicale (Paris, France : 1983) 20010421

Title: Chemotherapy for human immunodeficiency virus-associated non-Hodgkin's lymphoma in combination with highly active antiretroviral therapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010415

Title: Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology.

Journal: Analytical biochemistry 20010415

Title: Differences in the intracellular accumulation of HIV protease inhibitors in vitro and the effect of active transport.

Journal: AIDS (London, England) 20010413

Title: Indinavir and systemic hypertension.

Journal: AIDS (London, England) 20010413

Title: Long-term virologic and immunologic responses in human immunodeficiency virus type 1-infected children treated with indinavir, zidovudine, and lamivudine.

Journal: The Journal of infectious diseases 20010401

Title: Intracellular concentration of the HIV protease inhibitors indinavir and saquinavir in human endothelial cells.

Journal: The Journal of antimicrobial chemotherapy 20010401

Title: Effects of grapefruit juice on pharmacokinetic exposure to indinavir in HIV-positive subjects.

Journal: Journal of clinical pharmacology 20010401

Title: Smaller amounts of antiretroviral drugs are needed when combined with an active ribozyme against HIV-1.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20010401

Title: CT appearances of HIV-related lipodystrophy syndrome.

Journal: The British journal of radiology 20010401

Title: Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate.

Journal: The Journal of infection 20010401

Title: Sequencing of protease inhibitor therapy: insights from an analysis of HIV phenotypic resistance in patients failing protease inhibitors.

Journal: AIDS (London, England) 20010330

Title: Competition prompts drug companies to cut antiretroviral drug prices.

Journal: Lancet (London, England) 20010317

Title: Anti-AIDS drugs available 'at cost'.

Journal: Nature 20010315

Title: Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood--brain barrier.

Journal: AIDS (London, England) 20010309

Title: Abacavir-lamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial.

Journal: JAMA 20010307

Title: Indinavir, nevirapine, stavudine, and lamivudine for human immunodeficiency virus-infected, amprenavir-experienced subjects: AIDS Clinical Trials Group protocol 373.

Journal: The Journal of infectious diseases 20010301

Title: Alterations in T cell phenotype and human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy.

Journal: The Journal of infectious diseases 20010301

Title: Resolution of microsporidial keratoconjunctivitis in an AIDS patient treated with highly active antiretroviral therapy.

Journal: American journal of ophthalmology 20010301

Title: A retrospective, cohort-based survey of patients using twice-daily indinavir + ritonavir combinations: pharmacokinetics, safety, and efficacy.

Journal: Journal of acquired immune deficiency syndromes (1999) 20010301

Title: The safety and antiviral effect of protease inhibitors in children.

Journal: Pharmacotherapy 20010301

Title: Effect of indinavir on the pharmacokinetics of rifampicin in HIV-infected patients.

Journal: The Journal of pharmacy and pharmacology 20010301

Title: HIV/AIDS case histories: indinavir crystalluria.

Journal: AIDS patient care and STDs 20010301

Title: Durable HIV-1 suppression with indinavir after failing lamivudine-containing double nucleoside therapy: a randomized controlled trial.

Journal: Antiviral therapy 20010301

Title: Therapy with efavirenz plus indinavir in patients with extensive prior nucleoside reverse-transcriptase inhibitor experience: a randomized, double-blind, placebo-controlled trial.

Journal: The Journal of infectious diseases 20010201

Title: Human immunodeficiency virus (HIV) protease inhibitors have no effect on hepatitis C virus (HCV) serum levels of HIV-HCV co-infected patients.

Journal: International journal of antimicrobial agents 20010201

Title: Association between high serum prolactin levels and concomitant infections in HIV-infected patients.

Journal: Human immunology 20010201

Title: Sensitive and rapid method for the simultaneous quantification of the HIV-protease inhibitors indinavir, nelfinavir, ritonavir, and saquinavir in human plasma by reversed-phase liquid chromatography.

Journal: Therapeutic drug monitoring 20010201

Title: [Long-term immunologic response in HIV-infected patients with CD4 cell counts </= 50/mm3 when initiating protease inhibitor therapy].

Journal: Annales de medecine interne 20010201

Title: [Acute porphyria and indinavir].

Journal: Annales de dermatologie et de venereologie 20010201

Title: Viral excretion in cervicovaginal secretions of HIV-1-infected women receiving antiretroviral therapy.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20010201

Title: [Resistance to protease inhibitors].

Journal: Enfermedades infecciosas y microbiologia clinica 20010201

Title: The use of and response to second-line protease inhibitor regimens: results from the EuroSIDA study.

Journal: AIDS (London, England) 20010126

Title: Efficacy, tolerance, and pharmacokinetics of the combination of stavudine, nevirapine, nelfinavir, and saquinavir as salvage regimen after ritonavir or indinavir failure.

Journal: AIDS research and human retroviruses 20010120

Title: Indinavir, zidovudine, lamivudine: 3-year follow-up.

Journal: Annals of internal medicine 20010116

Title: Changes in host cell molecules acquired by circulating HIV-1 in patients treated with highly active antiretroviral therapy and interleukin-2.

Journal: AIDS (London, England) 20010105

Title: Pathological fractures in AIDS patients with osteopenia and osteoporosis induced by antiretroviral therapy.

Journal: AIDS (London, England) 20010105

Title: Paronychia in association with indinavir treatment.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010101

Title: Pharmacological basis for concentration-controlled therapy with zidovudine, lamivudine, and indinavir.

Journal: Antimicrobial agents and chemotherapy 20010101

Title: Effect of alpha1-acid glycoprotein on the intracellular accumulation of the HIV protease inhibitors saquinavir, ritonavir and indinavir in vitro.

Journal: British journal of clinical pharmacology 20010101

Title: The absence of hyperbilirubinaemia is highly predictive of treatment failure in advanced HIV-infected patients treated with indinavir.

Journal: International journal of STD & AIDS 20010101

Title: Economic analysis of initial HIV treatment. Efavirenz- versus indinavir-containing triple therapy.

Journal: PharmacoEconomics 20010101

Title: [Bilateral hip necrosis, corticoids, and human immunodeficiency virus protease inhibitors].

Journal: Enfermedades infecciosas y microbiologia clinica 20010101

Title: [Simultaneous quantitative determination of amprenavir and indinavir in human plasma by high-performance liquid chromatography].

Journal: Annales de biologie clinique 20010101

Title: Comparison of P-triglyceride levels among patients with human immunodeficiency virus on randomized treatment with ritonavir, indinavir or ritonavir/saquinavir.

Journal: Scandinavian journal of infectious diseases 20010101

Title: Recurrent ingrown toenails secondary to indinavir/ritonavir combination therapy.

Journal: The Annals of pharmacotherapy 20010101

Title: [AIDS, activism, and the regulation of clinical trials in Brazil: Protocol 028].

Journal: Cadernos de saude publica 20010101

Title: Effects of interleukin-2 therapy on the proliferation and differentiation of CD4/CD25 positive and CD4/CD25 negative cells in HIV+ patients.

Journal: European cytokine network 20010101

Title: Ritonavir and indinavir one year later.

Journal: TreatmentUpdate 20010101

Title: Using ritonavir with indinavir in cases of virologic failure.

Journal: TreatmentUpdate 20010101

Title: Merck pushes the envelope with once-daily indinavir.

Journal: TreatmentUpdate 20010101

Title: Combination therapy with indinavir, ritonavir, and delavirdine and nucleoside reverse transcriptase inhibitors in patients with HIV/AIDS who have failed multiple antiretroviral combinations.

Journal: HIV clinical trials 20010101

Title: Simultaneous determination of the new HIV protease inhibitor lopinavir (ABT 378) and of indinavir(1), amprenavir, saquinavir, ritonavir (ABT 538)(2) and nelfinavir(3) in human plasma by gradient HPLC.

Journal: Clinical laboratory 20010101

Title: Antiviral potency of HAART regimens and clinical success are not strictly coupled in real life conditions: evidence from the MASTER-1 study.

Journal: HIV clinical trials 20010101

Title: Low body weight and type of protease inhibitor predict discontinuation and treatment-limiting adverse drug reactions among HIV-infected patients starting a protease inhibitor regimen: consistent results from a randomized trial and an observational cohort.

Journal: HIV medicine 20010101

Title: Prediction of potential toxicity and side effect protein targets of a small molecule by a ligand-protein inverse docking approach.

Journal: Journal of molecular graphics & modelling 20010101

Title: Sugar blues and protease inhibitors.

Journal: TreatmentUpdate 20010101

Title: [Nephropathy caused by crystal deposits induced by indinavir].

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20010101

Title: [Nephrolithiasis in a HIV infected patient treated with indinavir].

Journal: Przeglad lekarski 20010101

Title: In vivo emergence of drug-resistant mutations at less than 50 HIV-1 RNA copies/mL that are maintained at viral rebound in longitudinal plasma samples from human immunodeficiency virus type-1-infected patients on highly active antiretroviral therapy.

Journal: Journal of human virology 20010101

Title: A pharmacokinetic drug-drug interaction study of venlafaxine and indinavir.

Journal: Psychopharmacology bulletin 20010101

Title: Increased prevalence and analysis of risk factors for indinavir nephrolithiasis.

Journal: The Journal of urology 20001201

Title: Symptomatic crystalluria associated with indinavir.

Journal: The Annals of pharmacotherapy 20001201

Title: Leucocytoclastic vasculitis and indinavir.

Journal: The British journal of dermatology 20001101

Title: Sudden anuria due to indinavir crystalluria.

Journal: Nephron 20001101

Title: Pyuria in patients treated with indinavir is associated with renal dysfunction.

Journal: Clinical nephrology 20001001

Title: [Anuria in HIV+ patients treated with indinavir].

Journal: Archivos espanoles de urologia 20001001

Title: Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.

Journal: Journal of medicinal chemistry 20000907

Title: Sudden unexpected death as a consequence of indinavir-induced nephropathy. A case report.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20000901

Title: 3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine.

Journal: Annals of internal medicine 20000704

Title: Drug resistance and drug combination features of the human immunodeficiency virus inhibitor, BCH-10652 [(+/-)-2'-deoxy-3'-oxa-4'-thiocytidine, dOTC].

Journal: Antiviral chemistry & chemotherapy 20000701

Title: Stimulation of vitamin A(1) acid signaling by the HIV protease inhibitor indinavir.

Journal: Biochemical pharmacology 20000501

Title: Indinavir calculi: diagnosis with magnetic resonance urography.

Journal: European urology 20000501

Title: In vitro activity of human immunodeficiency virus protease inhibitors against Pneumocystis carinii.

Journal: The Journal of infectious diseases 20000501

Title: Urinary cytology changes in protease inhibitor induced urolithiasis.

Journal: The Journal of urology 20000401

Title: Acute tubulointerstitial nephritis attributable to indinavir therapy.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20000401

Title: Severe hypertension and renal atrophy associated with indinavir.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20000301

Title: Synthesis and anti-HIV activity of prodrugs derived from saquinavir and indinavir.

Journal: Antiviral chemistry & chemotherapy 20000301

Title: Increased incidence of indinavir nephrolithiasis in patients with hepatitis B or C virus infection.

Journal: Antiviral therapy 20000301

Title: A randomized, comparative study of lamivudine plus stavudine, with indinavir or nelfinavir, in treatment-experienced HIV-infected patients.

Journal: AIDS (London, England) 20000128

Title: [Hemolytic anemia associated with indinavir administration].

Journal: Enfermedades infecciosas y microbiologia clinica 19991101

Title: Treatment for human immunodeficiency virus with indinavir may cause relevant urological side-effects, effectively treatable by rehydration.

Journal: BJU international 19991001

Title: Failure of indinavir to inhibit Candida albicans in vitro.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19991001

Title: Non-active site changes elicit broad-based cross-resistance of the HIV-1 protease to inhibitors.

Journal: The Journal of biological chemistry 19990820

Title: In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors.

Journal: The Journal of infectious diseases 19990801

Title: Influence of environmental temperature on incidence of indinavir-related nephrolithiasis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19990801

Title: Indinavir urolithiasis: an emerging cause of renal colic in patients with human immunodeficiency virus.

Journal: The Journal of urology 19990601

Title: [Treatment of complicated renal colic in patients treated with indinavir: value of double J stents].

Journal: Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 19990601

Title: Urolithiasis associated with protease inhibitors.

Journal: Journal of endourology 19990501

Title: Acute renal failure caused by indinavir in a patient with a single functioning kidney.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19990501

Title: Two episodes of acute renal failure, rhabdomyolysis, and severe hepatitis in an AIDS patient successively treated with ritonavir and indinavir.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19990501

Title: Haemolytic anaemia associated with indinavir.

Journal: Postgraduate medical journal 19990501

Title: Images in clinical medicine. Indinavir crystalluria.

Journal: The New England journal of medicine 19990429

Title: Frequency of urolithiasis in individuals seropositive for human immunodeficiency virus treated with indinavir is higher than previously assumed.

Journal: The Journal of urology 19990401

Title: Urological complaints in relation to indinavir plasma concentrations in HIV-infected patients.

Journal: AIDS (London, England) 19990311

Title: Indinavir-induced nephropathy.

Journal: Clinical nephrology 19990301

Title: [Indinavir-induced anuria].

Journal: Revista clinica espanola 19990301

Title: Case no. 3. Right flank pain. Crixivan lithiasis.

Journal: Techniques in urology 19990301

Title: [Discontinuing protease inhibitor treatment of HIV-1 patients for intolerance. Longitudinal study of 309 patients].

Journal: Presse medicale (Paris, France : 1983) 19990227

Title: Genetic variation and susceptibilities to protease inhibitors among subtype B and F isolates in Brazil.

Journal: Antimicrobial agents and chemotherapy 19990201

Title: Persistent flank pain, low-grade fever, and malaise in a woman treated with indinavir.

Journal: AIDS patient care and STDs 19990201

Title: [Hydronephrosis caused by indinavir].

Journal: Enfermedades infecciosas y microbiologia clinica 19990101

Title: Urolithiasis and the protease inhibitor indinavir.

Journal: European urology 19990101

Title: Changes in renal function associated with indinavir.

Journal: AIDS (London, England) 19981224

Title: Variation in incidence of indinavir-associated nephrolithiasis among HIV-positive patients.

Journal: AIDS (London, England) 19981224

Title: Severe coronary artery disease in a young HIV-infected man with no cardiovascular risk factor who was treated with indinavir.

Journal: AIDS (London, England) 19981224

Title: Persistent nephrolithiasis after discontinuation of indinavir therapy.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19981201

Title: [Clinical case of the month. Apropos of pancytopenia in a seropositive patient].

Journal: Revue medicale de Liege 19981201

Title: Rapid development of indinavir-induced asymptomatic crystalluria in a human immunodeficiency virus-negative patient.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19981001

Title: Nonopaque crystal deposition causing ureteric obstruction in patients with HIV undergoing indinavir therapy.

Journal: AJR. American journal of roentgenology 19980901

Title: Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.

Journal: Clinical nephrology 19980901

Title: New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development.

Journal: Journal of medicinal chemistry 19980827

Title: Crystalluria and urinary tract abnormalities associated with indinavir.

Journal: The Journal of urology 19980801

Title: Ureteral obstruction secondary to indinavir in the pediatric HIV population.

Journal: Pediatric radiology 19980801

Title: Nephrolithiasis from indinavir, a new human immunodeficiency virus drug.

Journal: The Journal of urology 19980601

Title: Subtle occurrence of indinavir-induced acute renal insufficiency.

Journal: AIDS (London, England) 19980528

Title: Selected highlights on women and HIV from the 5th Conference on Retroviruses and Opportunistic Infections.

Journal: BETA : bulletin of experimental treatments for AIDS : a publication of the San Francisco AIDS Foundation 19980401

Title: [Nephritic colic due to indinavir].

Journal: Presse medicale (Paris, France : 1983) 19980314

Title: Indinavir-induced renal failure.

Journal: AIDS (London, England) 19980305

Title: Indinavir crystalluria: identification of patients at increased risk of developing nephrotoxicity.

Journal: Archives of pathology & laboratory medicine 19980301

Title: Indinavir and interstitial nephritis.

Journal: Annals of internal medicine 19980215

Title: Anuria and acute renal failure resulting from indinavir sulfate induced nephrolithiasis.

Journal: The Journal of urology 19980201

Title: Indinavir-associated hepatitis in patients with advanced HIV infection.

Journal: International journal of STD & AIDS 19980101

Title: Acute interstitial nephritis secondary to the administration of indinavir.

Journal: The Annals of pharmacotherapy 19980101

Title: The integration of medicinal chemistry, drug metabolism, and pharmaceutical research and development in drug discovery and development. The story of Crixivan, an HIV protease inhibitor.

Journal: Pharmaceutical biotechnology 19980101

Title: [Urinary calculi and crystalluria in HIV+ patients treated with indinavir sulfate].

Journal: Presse medicale (Paris, France : 1983) 19971108

Title: Portal vein thrombosis in patients receiving indinavir, an HIV protease inhibitor.

Journal: AIDS (London, England) 19971101

Title: [Hemolytic jaundice related to ingestion of indinavir].

Journal: Presse medicale (Paris, France : 1983) 19971101

Title: Acute renal failure due to indinavir crystalluria and nephrolithiasis: report of two cases.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 19971001

Title: Indinavir sulfate renal toxicity in a pediatric hemophiliac with HIV infection.

Journal: The Annals of pharmacotherapy 19971001

Title: Protease inhibitor-induced urolithiasis.

Journal: Urology 19971001

Title: Urolithiasis associated with the protease inhibitor indinavir.

Journal: Urology 19971001

Title: Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites.

Journal: Journal of virology 19970901

Title: An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.

Journal: Journal of medicinal chemistry 19970801

Title: Crystalluria and urinary tract abnormalities associated with indinavir.

Journal: Annals of internal medicine 19970715

Title: Protease inhibitors and urolithiasis.

Journal: The Journal of urology 19970701

Title: Indinavir-induced nephropathy.

Journal: Tennessee medicine : journal of the Tennessee Medical Association 19970701

Title: [Crystalluria and nephrolithiasis during therapy with the protease inhibitor indinavir].

Journal: Deutsche medizinische Wochenschrift (1946) 19970613

Title: Urinary stones in HIV-1-positive patients treated with indinavir.

Journal: Lancet (London, England) 19970503

Title: In vitro effect of alpha1-acid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: a comparative study with other relevant HIV protease inhibitors.

Journal: The Journal of infectious diseases 19970501

Title: [Kidney colic under Indinavir [correction of indiavir] therapy in HIV infection].

Journal: Praxis 19970430

Title: Indinavir nephrolithiasis in warm climates.

Journal: Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 19970301

Title: Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19970201

Title: Indinavir nephropathy.

Journal: The New England journal of medicine 19970109

Title: Indinavir urinary stones as origin of upper urinary tract obstruction.

Journal: Urologia internationalis 19970101

Title: [A new cause of nephritic colic: indinavir. Apropos of a case].

Journal: La Revue de medecine interne 19970101

Title: [Urinary calculi and indinavir sulfate in patients with HIV infection. Apropos of 4 cases].

Journal: Journal d'urologie 19970101

Title: Medical alert: hemolytic anemia in Crixivan cohort.

Journal: Critical Path AIDS project 19970101

Title: Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity.

Journal: The Journal of biological chemistry 19961213

Title: Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.

Journal: Journal of virology 19961201

Title: Protease inhibitors shine in triple combinations.

Journal: AIDS alert 19960301

Title: Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19960220

Title: In vitro antiviral activity of 141W94 (VX-478) in combination with other antiretroviral agents.

Journal: Antiviral research 19960101

Title: Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure.

Journal: Biochemistry 19950725

Title: In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.

Journal: Nature 19950406

Title: L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.

Journal: Journal of medicinal chemistry 19941014

Title: L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19940426

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Tags:157810-81-6 Molecular Formula|157810-81-6 MDL|157810-81-6 SMILES|157810-81-6 D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-, sulfate (1:1)