Home Other Building Blocks 1597403-47-8
1597403-47-8,MFCD27952932
Catalog No.:AA001RAH

1597403-47-8 | Isrib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$23.00   $16.00
- +
10mg
98%
in stock  
$50.00   $35.00
- +
1g
98.00%
in stock  
$510.00   $357.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001RAH
Chemical Name:
Isrib
CAS Number:
1597403-47-8
Molecular Formula:
C22H24Cl2N2O4
Molecular Weight:
451.3430
MDL Number:
MFCD27952932
SMILES:
O=C(N[C@@H]1CC[C@H](CC1)NC(=O)COc1ccc(cc1)Cl)COc1ccc(cc1)Cl
Properties
Computed Properties
 
Complexity:
493  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
4.8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:UNIVERSITYOFCALIFORNIA-WO2014/144952,2014,A2Locationinpatent:Paragraph0409

Literature

Title: Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.

Journal: The Journal of biological chemistry 20180406

Title: ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis.

Journal: Archives of biochemistry and biophysics 20161101

Title: Sidrauski C, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498.

Title: Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stressgranule assembly. Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05033.

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SDS
Tags:1597403-47-8 Molecular Formula|1597403-47-8 MDL|1597403-47-8 SMILES|1597403-47-8 Isrib