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161735-79-1,MFCD08460604
Catalog No.:AA001VRU

161735-79-1 | Rasagiline mesylate

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Purity
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1mg
97%
in stock  
$7.00   $5.00
- +
50mg
97%
in stock  
$11.00   $8.00
- +
1g
97%
in stock  
$38.00   $27.00
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5g
97%
in stock  
$135.00   $95.00
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25g
98%
in stock  
$596.00   $417.00
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100g
97%
in stock  
$1,508.00   $1,056.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001VRU
Chemical Name:
Rasagiline mesylate
CAS Number:
161735-79-1
Molecular Formula:
C13H17NO3S
Molecular Weight:
267.3440
MDL Number:
MFCD08460604
SMILES:
CS(=O)(=O)O.C#CCN[C@@H]1CCc2c1cccc2
Properties
Computed Properties
 
Complexity:
305  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  

Downstream Synthesis Route

[1]AppliedCatalysisA:General,2015,vol.492,p.76-82

[2]Patent:US2009/292141,2009,A1.Locationinpatent:Page/Pagecolumn4

[3]Patent:EP2364967,2011,A2.Locationinpatent:Page/Pagecolumn13

[4]Patent:US8741962,2014,B2.Locationinpatent:Page/Pagecolumn17

[5]OrganicProcessResearchandDevelopment,2014,vol.18,p.1169-1174

[6]Patent:US2011/218361,2011,A1.Locationinpatent:Page/Pagecolumn4-5

[7]Patent:WO2015/70995,2015,A1.Locationinpatent:Page/Pagecolumn27

[8]Patent:CN109180499,2019,A.Locationinpatent:Paragraph0073-0079;0080-0085

[9]Patent:WO2009/147432,2009,A1.Locationinpatent:Page/Pagecolumn14

[10]Patent:US2007/112217,2007,A1.Locationinpatent:Page/Pagecolumn13

[11]Patent:WO2009/122301,2009,A2.Locationinpatent:Page/Pagecolumn12

[12]Patent:WO2010/13048,2010,A1.Locationinpatent:Page/Pagecolumn10

[13]Patent:WO2010/59913,2010,A2.Locationinpatent:Page/Pagecolumn23-24

[14]Patent:WO2012/96635,2012,A1.Locationinpatent:Page/Pagecolumn7

[15]Patent:WO2012/153349,2012,A2.Locationinpatent:Page/Pagecolumn29

[16]Patent:WO2013/54346,2013,A2.Locationinpatent:Page/Pagecolumn13

[17]Patent:US2014/18578,2014,A1.Locationinpatent:Paragraph0031

[1]Patent:US2008/161408,2008,A1.Locationinpatent:Page/Pagecolumn3

[2]Patent:US2009/318564,2009,A1.Locationinpatent:Page/Pagecolumn4

[3]Patent:US2008/146676,2008,A1.Locationinpatent:Page/Pagecolumn1-2

[4]Patent:US2008/161408,2008,A1.Locationinpatent:Page/Pagecolumn2;3

(R-(+)-N-propargyl-1-aminoindan)L-tartarate 
  161735-79-1    136236-51-6 

[1]Patent:US2008/161408,2008,A1.Locationinpatent:Page/Pagecolumn3

[1]CurrentPatentAssignee:CIPLALTD-WO2009/81148,2009,A1Locationinpatent:Page/Pagecolumn12-13

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Title: Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy.

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Title: Parkinson disease: an incremental challenge.

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Title: Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro.

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Title: Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway.

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Title: Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease.

Journal: Clinical therapeutics 20070901

Title: The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates.

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Title: Rasagiline as a therapy for Parkinson's disease (PD).

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Title: Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism.

Journal: Neurobiology of disease 20070101

Title: Rasagiline is neuroprotective in an experimental model of brain ischemia in the rat.

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Title: Rasagiline: a review of its use in the management of Parkinson's disease.

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Title: Community and long-term care management of Parkinson's disease in the elderly: focus on monoamine oxidase type B inhibitors.

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Title: Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers.

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Title: L-methamphetamine and selective MAO inhibitors decrease morphine-reinforced and non-reinforced behavior in rats; Insights towards selegiline's mechanism of action.

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Title: Rasagiline: A second-generation monoamine oxidase type-B inhibitor for the treatment of Parkinson's disease.

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Title: Safety of rasagiline in elderly patients with Parkinson disease.

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Title: Rasagiline improves quality of life in patients with early Parkinson's disease.

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Title: Cost-utility model of rasagiline in the treatment of advanced Parkinson's disease in Finland.

Journal: The Annals of pharmacotherapy 20060401

Title: Rasagiline -- is there a place for this drug in managing Parkinson's disease?

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Title: Rasagiline: defining the role of a novel therapy in the treatment of Parkinson's disease.

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Title: Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness.

Journal: British journal of pharmacology 20060101

Title: Concerning neuroprotective therapy for Parkinson's disease.

Journal: Journal of neural transmission. Supplementum 20060101

Title: Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety.

Journal: Journal of neural transmission. Supplementum 20060101

Title: New drugs: rasagiline mesylate, conivaptan hydrochloride, and sunitinib malate.

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Title: New drug treatment for Parkinson's disease.

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Title: Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection.

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Title: Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis.

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Title: Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine.

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Title: Neuroprotective effect of rasagiline, a monoamine oxidase-B inhibitor, on spontaneous cell degeneration in a rat model.

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Title: Clinical pharmacology of rasagiline: a novel, second-generation propargylamine for the treatment of Parkinson disease.

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Title: Reexamination of the TEMPO Study.

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Title: Rasagiline.

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Title: Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.

Journal: Annals of the New York Academy of Sciences 20050801

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Title: Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline.

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Title: Parkinson's disease. Diagnosis and the initiation of therapy.

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Title: Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004.

Journal: Movement disorders : official journal of the Movement Disorder Society 20050501

Title: Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives.

Journal: Brain research. Brain research reviews 20050401

Title: Novel pharmacological strategies for motor complications in Parkinson's disease.

Journal: Expert opinion on investigational drugs 20050401

Title: Characterization of the neuroprotective activity of rasagiline in cerebellar granule cells.

Journal: Neuropharmacology 20050301

Title: Rasagiline for motor complications in Parkinson's disease.

Journal: Lancet (London, England) 20050301

Title: Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial.

Journal: Lancet (London, England) 20050301

Title: Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases.

Journal: Mechanisms of ageing and development 20050201

Title: A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: the PRESTO study.

Journal: Archives of neurology 20050201

Title: Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition.

Journal: Journal of neuroscience research 20050101

Title: Movement disorders: understanding clinical trials.

Journal: The Lancet. Neurology 20050101

Title: Rasagiline.

Journal: Drugs & aging 20050101

Title: Neuroprotective therapy in Parkinson's disease and motor complications: a search for a pathogenesis-targeted, disease-modifying strategy.

Journal: Movement disorders : official journal of the Movement Disorder Society 20050101

Title: Neuroprotection by rasagiline: a new therapeutic approach to Parkinson's disease?

Journal: CNS drug reviews 20050101

Title: [The early therapy challenge].

Journal: Krankenpflege Journal 20050101

Title: [Are there innovations in the treatment of Parkinson's disease?].

Journal: Praxis 20041103

Title: Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease.

Journal: Neurology 20041012

Title: Clinical trials of neuroprotection for Parkinson's disease.

Journal: Neurology 20041012

Title: Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline.

Journal: British journal of pharmacology 20041001

Title: Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20041001

Title: Tolerability, safety, pharmacodynamics, and pharmacokinetics of rasagiline: a potent, selective, and irreversible monoamine oxidase type B inhibitor.

Journal: Pharmacotherapy 20041001

Title: Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040901

Title: Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model.

Journal: Journal of neurology 20040901

Title: Double-blind, randomized, controlled trial of rasagiline as monotherapy in early Parkinson's disease patients.

Journal: Movement disorders : official journal of the Movement Disorder Society 20040801

Title: Rasagiline enhances L-DOPA-induced contralateral turning in the unilateral 6-hydroxydopamine-lesioned guinea-pig.

Journal: Neuropharmacology 20040701

Title: Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease.

Journal: Experimental neurology 20040601

Title: Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo.

Journal: Journal of neurochemistry 20040601

Title: N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.

Journal: Neurochemistry international 20040501

Title: A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease.

Journal: Archives of neurology 20040401

Title: Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.

Journal: Journal of medicinal chemistry 20040325

Title: Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class.

Journal: Journal of medicinal chemistry 20040325

Title: Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline.

Journal: Neuroscience letters 20040130

Title: Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for Parkinson's disease?

Journal: BioEssays : news and reviews in molecular, cellular and developmental biology 20040101

Title: The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201

Title: The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline.

Journal: Biochemical pharmacology 20031015

Title: Amyloid processing and signal transduction properties of antiparkinson-antialzheimer neuroprotective drugs rasagiline and TV3326.

Journal: Annals of the New York Academy of Sciences 20030501

Title: Synthesis and initial results for MAO-B inhibition by new N-propargyl-3-pyrrol-1-ylindanamine derivatives, analogues of rasagiline.

Journal: Journal of enzyme inhibition and medicinal chemistry 20030401

Title: Monoamine oxidase inhibitors--is it time to up the TEMPO?

Journal: The Lancet. Neurology 20030301

Title: A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study.

Journal: Archives of neurology 20021201

Title: Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours.

Journal: Neuropharmacology 20021201

Title: Involvement of MAP kinase in the regulation of amyloid precursor protein processing by novel cholinesterase inhibitors derived from rasagiline.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

Title: Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan.

Journal: Journal of neurochemistry 20020801

Title: Test-retest reliability of the unified Parkinson's disease rating scale in patients with early Parkinson's disease: results from a multicenter clinical trial.

Journal: Movement disorders : official journal of the Movement Disorder Society 20020701

Title: An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells.

Journal: Neuroscience letters 20020628

Title: Rasagiline. Teva Pharmaceutical.

Journal: Current opinion in investigational drugs (London, England : 2000) 20020501

Title: Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020501

Title: Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline.

Journal: Mechanisms of ageing and development 20020430

Title: The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020401

Title: Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease.

Journal: Parkinsonism & related disorders 20020301

Title: Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].

Journal: Cellular and molecular neurobiology 20011201

Title: Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol.

Journal: Journal of neurochemistry 20010801

Title: Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs.

Journal: Annals of the New York Academy of Sciences 20010601

Title: Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

Journal: Annals of the New York Academy of Sciences 20010601

Title: The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo.

Journal: Annals of the New York Academy of Sciences 20010601

Title: Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy.

Journal: Annals of the New York Academy of Sciences 20010401

Title: Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B.

Journal: British journal of pharmacology 20010101

Title: Rasagiline and its (S) enantiomer increase survival and prevent stroke in salt-loaded stroke-prone spontaneously hypertensive rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders.

Journal: Journal of neural transmission. Supplementum 19980101

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Tags:161735-79-1 Molecular Formula|161735-79-1 MDL|161735-79-1 SMILES|161735-79-1 Rasagiline mesylate