Title: Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase.
Journal: Journal of medicinal chemistry20110526
Title: Inhibition of cyclooxygenase-2 impairs the expression of essential plasma cell transcription factors and human B-lymphocyte differentiation.
Journal: Immunology20100101
Title: Gastric and small bowel ileus after severe burn in rats: the effect of cyclooxygenase-2 inhibitors.
Journal: Burns : journal of the International Society for Burn Injuries20091201
Title: Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
Journal: Bioorganic & medicinal chemistry letters20090801
Title: Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells.
Journal: Cellular immunology20090101
Title: The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury.
Journal: The Tohoku journal of experimental medicine20080901
Title: Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy.
Journal: The Journal of pharmacology and experimental therapeutics20080501
Title: Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells.
Journal: Cancer immunology, immunotherapy : CII20080301
Title: CpG oligodeoxynucleotides induce cyclooxygenase-2 in human B lymphocytes: implications for adjuvant activity and antibody production.
Journal: Clinical immunology (Orlando, Fla.)20071101
Title: Cyclooxygenase-2 activity following traumatic brain injury in the developing rat.
Journal: Pediatric research20070901
Title: [Effects of selective cyclooxygenase-2 inhibitor on proliferation and apoptosis of human bladder cancer cell line T24].
Journal: Ai zheng = Aizheng = Chinese journal of cancer20070401
Title: Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats.
Journal: European journal of pharmacology20070105
Title: Cyclooxygenase-2 inhibition attenuates antibody responses against human papillomavirus-like particles.
Journal: Journal of immunology (Baltimore, Md. : 1950)20061201
Title: Myocardial protection by pioglitazone, atorvastatin, and their combination: mechanisms and possible interactions.
Journal: American journal of physiology. Heart and circulatory physiology20060901
Title: Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells.
Journal: Clinical immunology (Orlando, Fla.)20060701
Title: Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production.
Journal: Journal of neuroimmunology20060501
Title: Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors.
Journal: Molecular carcinogenesis20060401
Title: COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice.
Journal: Cardiovascular research20050901
Title: Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus.
Journal: Brain research20050719
Title: The dual role of prostaglandin E(2) in excitotoxicity and preconditioning-induced neuroprotection.
Journal: European journal of pharmacology20050704
Title: The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3).
Journal: Molecular cancer therapeutics20050501
Title: Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer.
Journal: The Journal of steroid biochemistry and molecular biology20050501
Title: The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells.
Journal: Experimental cell research20050115
Title: Inhibitory effects of Celecoxib and Sc-58125 on proliferation of human carcinoma of larynx Hep-2 in vitro.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban20050101
Title: Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo.
Journal: Brain research. Molecular brain research20041206
Title: Cyclooxygenase-2-derived endogenous prostacyclin enhances mouse embryo hatching.
Journal: Human reproduction (Oxford, England)20041201
Title: Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells.
Journal: Journal of the National Cancer Institute20041201
Title: Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP.
Journal: The Journal of clinical investigation20040915
Title: COX-2 Regulates the insulin-like growth factor I-induced potentiation of Zn(2+)-toxicity in primary cortical culture.
Journal: Molecular pharmacology20040901
Title: Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040715
Title: Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity.
Journal: European journal of pharmacology20040616
Title: Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells.
Journal: Carcinogenesis20040301
Title: COX-2 inhibition results in alterations in nuclear factor (NF)-kappaB activation but not cytokine production in acute pancreatitis.
Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract20040101
Title: Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions.
Journal: Surgery20030501
Title: NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation.
Journal: Prostaglandins, leukotrienes, and essential fatty acids20021001
Title: Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression.
Journal: The Journal of biological chemistry20020510
Title: Radiosynthesis, in vitro validation, and in vivo evaluation of 18F-labeled COX-1 and COX-2 inhibitors.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20020101
Title: Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
Journal: Journal of molecular graphics & modelling20020101
Title: Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.
Journal: Journal of medicinal chemistry20010927
Title: A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts.
Journal: Neoplasia (New York, N.Y.)20010901
Title: The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20010815
Title: Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP.
Journal: American journal of physiology. Cell physiology20010801
Title: Heme oxygenase-1 induction by nitric oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor.
Journal: Biochimica et biophysica acta20010403
Title: Aspirin, but not the more selective cyclooxygenase (COX)-2 inhibitors meloxicam and SC 58125, aggravates postischaemic cardiac dysfunction, independent of COX function.
Journal: Naunyn-Schmiedeberg's archives of pharmacology20010201
Title: Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.
Journal: Gastroenterology20000601
Title: Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.
Journal: Cancer research19980115
Title: Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
Journal: British journal of pharmacology19970501
Title: Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.
Journal: Journal of medicinal chemistry19970314
