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169590-41-4,MFCD09837763
Catalog No.:AA00ABGZ

169590-41-4 | Deracoxib

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10mg
98%
in stock  
$7.00   $5.00
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50mg
98%
in stock  
$9.00   $7.00
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250mg
99%(HPLC)
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$34.00   $24.00
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1g
98%
in stock  
$47.00   $33.00
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5g
99%(HPLC)
in stock  
$196.00   $137.00
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25g
99%(HPLC)
in stock  
$648.00   $454.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABGZ
Chemical Name:
Deracoxib
CAS Number:
169590-41-4
Molecular Formula:
C17H14F3N3O3S
Molecular Weight:
397.3716
MDL Number:
MFCD09837763
SMILES:
COc1ccc(cc1F)c1cc(nn1c1ccc(cc1)S(=O)(=O)N)C(F)F
NSC Number:
758935
Properties
Computed Properties
 
Complexity:
596  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.8  

Literature

Title: Effects of carprofen, meloxicam and deracoxib on platelet function in dogs.

Journal: Veterinary anaesthesia and analgesia 20120301

Title: Toxicology of frequently encountered nonsteroidal anti-inflammatory drugs in dogs and cats.

Journal: The Veterinary clinics of North America. Small animal practice 20120301

Title: Ethyl 2-[(2,4-difluoro-phen-yl)hydrazinyl-idene]-3-oxobutano-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: Complications from residual adnexal structures following enucleation in three dogs.

Journal: Journal of the American Veterinary Medical Association 20111215

Title: Antitumor effects of deracoxib treatment in 26 dogs with transitional cell carcinoma of the urinary bladder.

Journal: Journal of the American Veterinary Medical Association 20111015

Title: Ethyl 2-[2-(2-meth-oxy-phen-yl)hydrazinyl-idene]-3-oxobutano-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: 4-[2-(4-Chloro-phen-yl)hydrazinyl-idene]-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-1-carbothio-amide.

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: Ethyl 2-[2-(3-meth-oxy-phen-yl)hydrazinyl-idene]-3-oxobutano-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: Effect of cyclooxygenase inhibitors in a xenograft model of canine mammary tumours.

Journal: Veterinary and comparative oncology 20110901

Title: Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.

Journal: European journal of pharmacology 20110611

Title: The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses.

Journal: Journal of veterinary pharmacology and therapeutics 20110201

Title: Determination of firocoxib in equine plasma using high performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110115

Title: Spontaneous pneumothorax in a dog secondary to Dirofilaria immitis infection.

Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20101101

Title: In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study.

Journal: Research in veterinary science 20100601

Title: Characterization and modulation of canine mast cell derived eicosanoids.

Journal: Veterinary immunology and immunopathology 20100515

Title: Effects of aspirin, carprofen, deracoxib, and meloxicam on platelet function and systemic prostaglandin concentrations in healthy dogs.

Journal: American journal of veterinary research 20100301

Title: Proximal duodenal perforation in three dogs following deracoxib administration.

Journal: Journal of the American Animal Hospital Association 20100101

Title: Randomised controlled clinical trial for the use of deracoxib during intense rehabilitation exercises after tibial plateau levelling osteotomy.

Journal: Veterinary and comparative orthopaedics and traumatology : V.C.O.T 20100101

Title: Use of deracoxib during intense rehabilitation exercises.

Journal: Veterinary and comparative orthopaedics and traumatology : V.C.O.T 20100101

Title: Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs.

Journal: American journal of veterinary research 20091001

Title: Safety and tolerability of 3-week and 6-month dosing of Deramaxx (deracoxib) chewable tablets in dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20090801

Title: Evaluation of outcome associated with subcutaneous and intramuscular hemangiosarcoma treated with adjuvant doxorubicin in dogs: 21 cases (2001-2006).

Journal: Journal of the American Veterinary Medical Association 20080701

Title: Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs.

Journal: American journal of veterinary research 20080401

Title: Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs): a systematic structured review of the literature.

Journal: Archives of dermatological research 20070701

Title: Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs.

Journal: American journal of veterinary research 20070301

Title: Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Effect of short-term sequential administration of nonsteroidal anti-inflammatory drugs on the stomach and proximal portion of the duodenum in healthy dogs.

Journal: American journal of veterinary research 20061001

Title: Effects of deracoxib and aspirin on serum concentrations of thyroxine, 3,5,3'-triiodothyronine, free thyroxine, and thyroid-stimulating hormone in healthy dogs.

Journal: American journal of veterinary research 20060401

Title: Extraskeletal osteosarcoma associated with retained surgical sponge in a dog.

Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20060301

Title: The effects of epidural deracoxib on the ground reaction forces in an acute stifle synovitis model.

Journal: Veterinary surgery : VS 20060101

Title: Disposition of deracoxib in cats after oral administration.

Journal: Journal of the American Animal Hospital Association 20060101

Title: Effects of deracoxib or buffered aspirin on the gastric mucosa of healthy dogs.

Journal: Journal of veterinary internal medicine 20060101

Title: Investigation of the effects of deracoxib and piroxicam on the in vitro viability of osteosarcoma cells from dogs.

Journal: American journal of veterinary research 20051101

Title: Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002-2003).

Journal: Journal of the American Veterinary Medical Association 20051001

Title: Determination of deracoxib in feline plasma samples using high performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

Title: In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis.

Journal: American journal of veterinary research 20050501

Title: Effects of cyclooxygenase inhibitors flunixin and deracoxib on permeability of ischaemic-injured equine jejunum.

Journal: Equine veterinary journal 20050101

Title: Nonsteroidal antiinflammatory drugs: a review.

Journal: Journal of the American Animal Hospital Association 20050101

Title: In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis.

Journal: American journal of veterinary research 20040401

Title: Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.

Journal: Journal of medicinal chemistry 20010927

Title: Royals, S.R., et al., Investigation of the effects of deracoxib and piroxicam on the in vitro viability of osteosarcoma cells from dogs. Am J Vet Res, 2005. 66(11): p. 1961-7.

Title: Ustun Alkan, F., et al., The effects of piroxicam and deracoxib on canine mammary tumour cell line. ScientificWorldJournal, 2012. 2012: p. 976740.

Title: Bienhoff, S.E., et al., Efficacy and safety of deracoxib for control of postoperative pain and inflammation associated with soft tissue surgery in dogs. Vet Surg, 2012. 41(3): p. 336-44.

Title: McMillan, S.K., et al., Antitumor effects of deracoxib treatment in 26 dogs with transitional cell carcinoma of the urinary bladder. J Am Vet Med Assoc, 2011. 239(8): p. 1084-9.

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