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16220-07-8,MFCD00057096
Catalog No.:AA001ST2

16220-07-8 | 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$68.00   $47.00
- +
10mg
≥95%
in stock  
$120.00   $84.00
- +
25mg
≥95%
in stock  
$260.00   $182.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001ST2
Chemical Name:
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
CAS Number:
16220-07-8
Molecular Formula:
C10H12N4O5
Molecular Weight:
268.2261
MDL Number:
MFCD00057096
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ncc2c1nc[nH]c2=O
Properties
Computed Properties
 
Complexity:
405  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-2.3  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,1982,vol.25,p.1040-1044

Literature

Title: New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

Journal: Journal of medicinal chemistry 19951124

Title: Activity of inosine analogs against Pneumocystis carinii in culture.

Journal: Antimicrobial agents and chemotherapy 19860701

Title: Synthesis and antiviral activity of certain carbamoylpyrrolopyrimidine and pyrazolopyrimidine nucleosides.

Journal: Journal of medicinal chemistry 19821101

Title: Nishida Y, et al. Inhibition of purine nucleoside phosphorylase activity and of T-cell function with allopurinol-riboside. Agents Actions. 1979 Dec;9(5-6):549-52.

Title: Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.

Title: Shapiro TA, et al. Pharmacokinetics and metabolism of allopurinol riboside. Clin Pharmacol Ther. 1991 May;49(5):506-14.

Title: Were JB, et al. Effects of probenecid on the pharmacokinetics of allopurinol riboside. Antimicrob Agents Chemother. 1993 May;37(5):1193-6.

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SDS
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Tags:16220-07-8 Molecular Formula|16220-07-8 MDL|16220-07-8 SMILES|16220-07-8 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
Catalog No.: AA001ST2
16220-07-8,MFCD00057096
16220-07-8 | 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
Pack Size： 5mg
Purity： ≥95%
in stock
$68.00 $47.00
Pack Size： 10mg
Purity： ≥95%
in stock
$120.00 $84.00
Pack Size： 25mg
Purity： ≥95%
in stock
$260.00 $182.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001ST2
Chemical Name: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
CAS Number: 16220-07-8
Molecular Formula: C10H12N4O5
Molecular Weight: 268.2261
MDL Number: MFCD00057096
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ncc2c1nc[nH]c2=O
Properties
Complexity: 405  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 4  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -2.3  
Downstream Synthesis Route
315-30-0    58-96-8    16220-07-8 

[1]JournalofMedicinalChemistry,1982,vol.25,p.1040-1044

Literature fold

Title: New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

Journal: Journal of medicinal chemistry19951124

Title: Activity of inosine analogs against Pneumocystis carinii in culture.

Journal: Antimicrobial agents and chemotherapy19860701

Title: Synthesis and antiviral activity of certain carbamoylpyrrolopyrimidine and pyrazolopyrimidine nucleosides.

Journal: Journal of medicinal chemistry19821101

Title: Nishida Y, et al. Inhibition of purine nucleoside phosphorylase activity and of T-cell function with allopurinol-riboside. Agents Actions. 1979 Dec;9(5-6):549-52.

Title: Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.

Title: Shapiro TA, et al. Pharmacokinetics and metabolism of allopurinol riboside. Clin Pharmacol Ther. 1991 May;49(5):506-14.

Title: Were JB, et al. Effects of probenecid on the pharmacokinetics of allopurinol riboside. Antimicrob Agents Chemother. 1993 May;37(5):1193-6.

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