Title: Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells.
Journal: Toxicology letters20180701
Title: Disease modifying therapies for relapsing multiple sclerosis.
Journal: BMJ (Clinical research ed.)20160822
Title: Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.
Journal: Journal of medicinal chemistry20160211
Title: FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.
Journal: Toxicology letters20150702
Title: Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin.
Journal: PloS one20150101
Title: Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
Journal: Journal of neuroinflammation20150101
Title: Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.
Journal: ACS medicinal chemistry letters20141211
Title: Analysis of Onset Mechanisms of a Sphingosine 1-Phosphate Receptor Modulator Fingolimod-Induced Atrioventricular Conduction Block and QT-Interval Prolongation.
Journal: Toxicology and applied pharmacology20141115
Title: FTY720 attenuates paraquat-induced lung injury in mice.
Journal: International immunopharmacology20140801
Title: Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.
Journal: Nature neuroscience20140701
Title: Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis.
Journal: Journal of medicinal chemistry20140626
Title: ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
Journal: PloS one20140101
Title: Modulators of the Sphingosine 1-phosphate receptor 1.
Journal: Bioorganic & medicinal chemistry letters20131201
Title: Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod.
Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society20130601
Title: Drugs in development for relapsing multiple sclerosis.
Journal: Drugs20130501
Title: Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3.
Journal: Journal of immunology (Baltimore, Md. : 1950)20130401
Title: Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.
Journal: British journal of pharmacology20130301
Title: Early tolerability and safety of fingolimod in clinical practice.
Journal: Journal of the neurological sciences20121215
Title: Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway.
Journal: Biochimie20121201
Title: Effect of alkyl chain length on sphingosine kinase 2 selectivity.
Journal: Bioorganic & medicinal chemistry letters20121115
Title: Withdrawal of fingolimod treatment for relapsing-remitting multiple sclerosis: report of six cases.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20121101
Title: Severe multiple sclerosis reactivation under fingolimod 3 months after natalizumab withdrawal.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20121101
Title: Switching therapy from natalizumab to fingolimod in relapsing-remitting multiple sclerosis: clinical and magnetic resonance imaging findings.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20121101
Title: Emerging tumefactive multiple sclerosis after switching therapy from natalizumab to fingolimod.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20121101
Title: Focus on molecules: Sphingosine 1 Phosphate (S1P).
Journal: Experimental eye research20121001
Title: Sudden unexpected death on fingolimod.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20121001
Title: Effects of FTY720 and rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat.
Journal: Pancreas20121001
Title: New disease-modifying therapies and new challenges for MS.
Journal: Current neurology and neuroscience reports20121001
Title: Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720.
Journal: Birth defects research. Part A, Clinical and molecular teratology20121001
Title: A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.
Journal: Chemistry & biology20120921
Title: Disease-modifying drugs for multiple sclerosis in pregnancy: a systematic review.
Journal: Neurology20120911
Title: The safety risks of innovation: the FDA's Expedited Drug Development Pathway.
Journal: JAMA20120905
Title: A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20120901
Title: A patient with Leiden V mutation, multiple sclerosis, psoriasis, and sicca syndrome: could celecoxib and fingolimod adversely affect the heart?
Journal: Cardiovascular toxicology20120901
Title: Fingolimod--a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes.
Journal: Glia20120901
Title: 4-aminopyridine toxicity: a case report and review of the literature.
Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology20120901
Title: Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.
Journal: Acta neuropathologica20120901
Title: Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice.
Journal: Vascular pharmacology20120819
Title: S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.
Journal: Blood20120816
Title: [Infections and fingolimod].
Journal: Revista de neurologia20120816
Title: Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.
Journal: The Journal of pharmacology and experimental therapeutics20120801
Title: Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo.
Journal: Transplant immunology20120801
Title: A fluorescent assay for ceramide synthase activity.
Journal: Journal of lipid research20120801
Title: Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results.
Journal: International journal of clinical pharmacology and therapeutics20120801
Title: Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.
Journal: International journal of rheumatic diseases20120801
Title: Population pharmacokinetics of fingolimod phosphate in healthy participants.
Journal: Journal of clinical pharmacology20120701
Title: Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model.
Journal: Breast cancer research and treatment20120701
Title: The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists.
Journal: Xenobiotica; the fate of foreign compounds in biological systems20120701
Title: The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro.
Journal: International journal of molecular medicine20120701
Title: [Basic mechanisms of action of fingolimod in relation to multiple sclerosis].
Journal: Revista de neurologia20120701
Title: Cost-effectiveness of early initiation of fingolimod versus delayed initiation after 1 year of intramuscular interferon beta-1a in patients with multiple sclerosis.
Journal: Clinical therapeutics20120701
Title: [Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 (fingolimod) in combination with betamethasone ointment in NC/Nga mice].
Journal: Arerugi = [Allergy]20120701
Title: Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.
Journal: Biochemical and biophysical research communications20120622
Title: First-line disease-modifying therapies in paediatric multiple sclerosis: a comprehensive overview.
Journal: Drugs20120618
Title: Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation.
Journal: Bone marrow transplantation20120601
Title: FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.
Journal: British journal of pharmacology20120601
Title: FTY720 mediates activation suppression and G(0)/G (1) cell cycle arrest in a concanavalin A-induced mouse lymphocyte pan-activation model.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20120601
Title: Emerging disease-modifying therapies in multiple sclerosis.
Journal: Current treatment options in neurology20120601
Title: Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.
Journal: Neurochemical research20120601
Title: Overview of treatment options in multiple sclerosis.
Journal: The Journal of clinical psychiatry20120601
Title: [Assessment of the clinical and MRI results of the FREEDOMS and TRANSFORMS phase III. clinical trials].
Journal: Ideggyogyaszati szemle20120530
Title: Structure of the first sphingosine 1-phosphate receptor.
Journal: Science signaling20120522
Title: FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells.
Journal: Neuroscience letters20120516
Title: Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.
Journal: Journal of immunology (Baltimore, Md. : 1950)20120515
Title: Building a better sphingosine kinase-1 inhibitor.
Journal: The Biochemical journal20120515
Title: Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).
Journal: Journal of medicinal chemistry20120510
Title: [Multiple sclerosis: beyong first line therapies].
Journal: Revue medicale suisse20120502
Title: Annualized relapse rate of first-line treatments for multiple sclerosis: a meta-analysis, including indirect comparisons versus fingolimod.
Journal: Current medical research and opinion20120501
Title: MS clinical trials: what can subgroup analyses teach us?
Journal: The Lancet. Neurology20120501
Title: Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study.
Journal: The Lancet. Neurology20120501
Title: Immunotherapies in neurologic disorders.
Journal: The Medical clinics of North America20120501
Title: Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models.
Journal: Oncogene20120419
Title: [New disease-modifying and symptomatic therapies for multiple sclerosis].
Journal: MMW Fortschritte der Medizin20120419
Title: Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure.
Journal: American journal of physiology. Lung cellular and molecular physiology20120415
Title: Drugs: An injection of hope.
Journal: Nature20120412
Title: Autophagy induced by FTY720 promotes apoptosis in U266 cells.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20120411
Title: Treatments for relapsing-remitting multiple sclerosis: summarising current information by network meta-analysis.
Journal: European journal of clinical pharmacology20120401
Title: Placebo-controlled study of the effects of fingolimod on cardiac rate and rhythm and pulmonary function in healthy volunteers.
Journal: European journal of clinical pharmacology20120401
Title: Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.
Journal: Journal of cellular biochemistry20120401
Title: Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics.
Journal: The Journal of pathology20120401
Title: Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.
Journal: The American journal of pathology20120401
Title: Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.
Journal: Neuro-oncology20120401
Title: FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms.
Journal: The American journal of pathology20120401
Title: Network analysis of randomized controlled trials in multiple sclerosis.
Journal: Clinical therapeutics20120401
Title: [2012: Update on diagnosis and treatment of multiple sclerosis].
Journal: Deutsche medizinische Wochenschrift (1946)20120401
Title: Fingolimod: cardiovascular deaths.
Journal: Prescrire international20120401
Title: Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis.
Journal: Future medicinal chemistry20120401
Title: Structural requirements of membrane phospholipids for M-type potassium channel activation and binding.
Journal: The Journal of biological chemistry20120323
Title: Severe multiple sclerosis relapse under fingolimod therapy: incident or coincidence?
Journal: Neurology20120320
Title: Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation.
Journal: Cell and tissue research20120301
Title: [(11)C]DAC-PET for noninvasively monitoring neuroinflammation and immunosuppressive therapy efficacy in rat experimental autoimmune encephalomyelitis model.
Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology20120301
Title: Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation.
Journal: Transplant immunology20120301
Title: LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20120301
Title: FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment?
Journal: Autophagy20120301
Title: FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20120301
Title: Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice.
Journal: Blood20120301
Title: Fingolimod-associated macular edema: incidence, detection, and management.
Journal: Neurology20120227
Title: Agency is under fire for refusing to supply details of sudden deaths after first dose of multiple sclerosis drug.
Journal: BMJ (Clinical research ed.)20120223
Title: FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2).
Journal: The Journal of biological chemistry20120217
Title: Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis.
Journal: British journal of pharmacology20120201
Title: Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue?
Journal: British journal of pharmacology20120201
Title: Insights into the pharmacological relevance of lysophospholipid receptors.
Journal: British journal of pharmacology20120201
Title: [Fingolimod treatment for multiple sclerosis patients. Infectiological aspects and recommendations for vaccinations].
Journal: Der Nervenarzt20120201
Title: Inhibitors of specific ceramide synthases.
Journal: Biochimie20120201
Title: S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis.
Journal: Molecular pharmacology20120201
Title: Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier.
Journal: The American journal of pathology20120201
Title: Does fingolimod in multiple sclerosis patients cause macular edema?
Journal: Journal of neurology20120201
Title: Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.
Journal: Cell cycle (Georgetown, Tex.)20120201
Title: Fingolimod for multiple sclerosis.
Journal: Drug and therapeutics bulletin20120201
Title: Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment.
Journal: Archives of neurology20120201
Title: Novel targeted therapies for mantle cell lymphoma.
Journal: Oncotarget20120201
Title: Synthesis and immunomodulating activity of new analogues of fingolimod.
Journal: Archiv der Pharmazie20120201
Title: New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis.
Journal: Current opinion in neurology20120201
Title: [Role of S1P acting both inside and outside the cells].
Journal: Seikagaku. The Journal of Japanese Biochemical Society20120201
Title: Fingolimod for multiple sclerosis.
Journal: The New England journal of medicine20120126
Title: Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis20120125
Title: [Neurology].
Journal: Revue medicale suisse20120111
Title: Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy.
Journal: Clinical immunology (Orlando, Fla.)20120101
Title: Sphingosine 1-phosphate in coagulation and inflammation.
Journal: Seminars in immunopathology20120101
Title: The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis.
Journal: Molecular biology reports20120101
Title: Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.
Journal: Bioorganic & medicinal chemistry letters20120101
Title: Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
Journal: Bioorganic & medicinal chemistry20120101
Title: Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20120101
Title: Clinical pharmacokinetics of fingolimod.
Journal: Clinical pharmacokinetics20120101
Title: Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.
Journal: Annual review of immunology20120101
Title: Shining a light on intestinal traffic.
Journal: Clinical & developmental immunology20120101
Title: Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.
Journal: Cellular immunology20120101
Title: Current status of the immunomodulation and immunomediated therapeutic strategies for multiple sclerosis.
Journal: Clinical & developmental immunology20120101
Title: Current treatment strategies for multiple sclerosis - efficacy versus neurological adverse effects.
Journal: Current pharmaceutical design20120101
Title: Anti-CD25 (daclizumab) monoclonal antibody therapy in relapsing-remitting multiple sclerosis.
Journal: Clinical immunology (Orlando, Fla.)20120101
Title: Efficacy of vitamin D supplementation in multiple sclerosis (EVIDIMS Trial): study protocol for a randomized controlled trial.
Journal: Trials20120101
Title: FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells.
Journal: PloS one20120101
Title: [Research progress of the selective sphingosine-1-phosphate receptor 1 agonists].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica20120101
Title: Pre-existing T- and B-cell defects in one progressive multifocal leukoencephalopathy patient.
Journal: PloS one20120101
Title: In vitro and in vivo antagonism of a G protein-coupled receptor (S1P3) with a novel blocking monoclonal antibody.
Journal: PloS one20120101
Title: Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice.
Journal: Molecular vision20120101
Title: Novel therapies for aggressive B-cell lymphoma.
Journal: Advances in hematology20120101
Title: Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study.
Journal: Autoimmune diseases20120101
Title: Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swine.
Journal: PloS one20120101
Title: Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.
Journal: PloS one20120101
Title: Immune therapy of multiple sclerosis--future strategies.
Journal: Current pharmaceutical design20120101
Title: Current immune therapies of autoimmune disease of the nervous system with special emphasis to multiple sclerosis.
Journal: Current pharmaceutical design20120101
Title: [Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova20120101
Title: Topographical and biological evidence revealed FTY720-mediated anergy-polarization of mouse bone marrow-derived dendritic cells in vitro.
Journal: PloS one20120101
Title: Oral FTY720 administration induces immune tolerance and inhibits early development of atherosclerosis in apolipoprotein E-deficient mice.
Journal: International journal of immunopathology and pharmacology20120101
Title: Effect of FTY720 on some physiological indexes of Non-Obese Diabetic (NOD) Mice.
Journal: International journal of molecular sciences20120101
Title: Therapeutic approach to steroid-resistant dermatitis using novel immunomodulator FTY720 (Fingolimod) in combination with betamethasone ointment in NC/Nga mice.
Journal: Biological & pharmaceutical bulletin20120101
Title: Dealing with excess of zeros in the statistical analysis of magnetic resonance imaging lesion count in multiple sclerosis.
Journal: Pharmaceutical statistics20120101
Title: Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach.
Journal: Drug design, development and therapy20120101
Title: Fingolimod in the treatment algorithm of relapsing remitting multiple sclerosis: a statement of the Central and East European (CEE) MS Expert Group.
Journal: Wiener medizinische Wochenschrift (1946)20120101
Title: Early bilateral cystoid macular oedema secondary to fingolimod in multiple sclerosis.
Journal: Case reports in medicine20120101
Title: Synthesis of a key intermediate for the preparation of FTY720 analogs.
Journal: Chemical & pharmaceutical bulletin20120101
Title: FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death.
Journal: Blood20111222
Title: Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Journal: Circulation20111213
Title: Current therapeutic options in pediatric multiple sclerosis.
Journal: Current treatment options in neurology20111201
Title: Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.
Journal: Gastroenterology20111201
Title: Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Journal: Pharmacology & therapeutics20111201
Title: Emerging oral drugs for relapsing-remitting multiple sclerosis.
Journal: Expert opinion on emerging drugs20111201
Title: FTY720-induced conversion of conventional Foxp3- CD4+ T cells to Foxp3+ regulatory T cells in NOD mice.
Journal: American journal of reproductive immunology (New York, N.Y. : 1989)20111101
Title: Delayed fingolimod-associated asystole.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20111101
Title: Targeting sphingosine-1-phosphate in hematologic malignancies.
Journal: Anti-cancer agents in medicinal chemistry20111101
Title: Oral fingolimod (FTY720) in relapsing multiple sclerosis: impact on health-related quality of life in a phase II study.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20111101
Title: The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice.
Journal: International immunopharmacology20111101
Title: FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20111101
Title: Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.
Journal: Cancer research20111101
Title: Background and rationale for mechanism of action, efficacy, and safety of fingolimod (Gilenya), the first oral therapy for remitting-relapsing multiple sclerosis: with special emphasis upon visual safety.
Journal: Current opinion in ophthalmology20111101
Title: Oral treatment for multiple sclerosis.
Journal: The Lancet. Neurology20111101
Title: Short-term immunossupressive treatment of the donor does not prevent ischemia-reperfusion kidney damage in the rat.
Journal: Transplantation proceedings20111101
Title: [Multiple sclerosis: current therapies and future perspectives].
Journal: Nihon rinsho. Japanese journal of clinical medicine20111101
Title: Discovery of a brain-penetrant S1P₃-sparing direct agonist of the S1P₁ and S1P₅ receptors efficacious at low oral dose.
Journal: Journal of medicinal chemistry20111013
Title: Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2.
Journal: Cellular and molecular neurobiology20111001
Title: (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Journal: Cellular signalling20111001
Title: Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.
Journal: American journal of physiology. Heart and circulatory physiology20111001
Title: Fingolimod for multiple sclerosis: mechanism of action, clinical outcomes, and future directions.
Journal: Current neurology and neuroscience reports20111001
Title: Fingolimod treatment for multiple sclerosis patients What do we do with varicella?
Journal: Annals of neurology20111001
Title: [The study of FTY720 on inducing apoptosis and autophagy in multiple myeloma cell line U266].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi20111001
Title: Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Journal: Biochemical and biophysical research communications20110923
Title: The effect of FTY720 in the Theiler's virus model of multiple sclerosis.
Journal: Journal of the neurological sciences20110915
Title: Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.
Journal: Nature reviews. Urology20110913
Title: Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia.
Journal: Blood20110908
Title: FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2.
Journal: The Journal of biological chemistry20110902
Title: There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells.
Journal: Neurochemical research20110901
Title: The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice.
Journal: Autoimmunity20110901
Title: TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720.
Journal: International immunopharmacology20110901
Title: Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.
Journal: The Journal of pharmacology and experimental therapeutics20110901
Title: Emerging country pharmacology: a 10-year perspective from Naunyn-Schmiedeberg's Archives of Pharmacology.
Journal: Naunyn-Schmiedeberg's archives of pharmacology20110901
Title: MS Forum/MS Over the Past 17 Years.
Journal: International MS journal20110901
Title: Multiple Sclerosis: The Big Questions- The MS Forum Workshop.
Journal: International MS journal20110901
Title: Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.
Journal: Molecular and cellular neurosciences20110901
Title: FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.
Journal: Journal of immunology (Baltimore, Md. : 1950)20110901
Title: Branch retinal vein occlusion during fingolimod treatment in a patient with multiple sclerosis.
Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society20110901
Title: A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).
Journal: Discovery medicine20110901
Title: Potential mechanisms of efficacy and adverse effects in the use of fingolimod (FTY720).
Journal: Expert review of clinical pharmacology20110901
Title: Multiple sclerosis: pathogenesis and treatment.
Journal: Current neuropharmacology20110901
Title: Toxicities of immunosuppressive treatment of autoimmune neurologic diseases.
Journal: Current neuropharmacology20110901
Title: NICE rules out NHS prescription of fingolimod for multiple sclerosis.
Journal: BMJ (Clinical research ed.)20110810
Title: Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model.
Journal: Digestive diseases and sciences20110801
Title: The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.
Journal: Pulmonary pharmacology & therapeutics20110801
Title: Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20110801
Title: Oral fingolimod for the treatment of patients with relapsing forms of multiple sclerosis.
Journal: International journal of clinical practice20110801
Title: Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B.
Journal: Current opinion in chemical biology20110801
Title: Fingolimod: a review of its use in the management of relapsing-remitting multiple sclerosis.
Journal: CNS drugs20110801
Title: Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report.
Journal: Archives of dermatology20110801
Title: Multiple sclerosis treatment: First oral drug, new antibody therapies.
Journal: JAAPA : official journal of the American Academy of Physician Assistants20110801
Title: Redirected tumor-specific allogeneic T cells for universal treatment of cancer.
Journal: Blood20110728
Title: Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival.
Journal: Transplantation20110715
Title: Purification and identification of activating enzymes of CS-0777, a selective sphingosine 1-phosphate receptor 1 modulator, in erythrocytes.
Journal: The Journal of biological chemistry20110715
Title: Multiple sclerosis: Cladribine--a contentious therapeutic contender for MS.
Journal: Nature reviews. Neurology20110712
Title: FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl.
Journal: The European respiratory journal20110701
Title: FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells.
Journal: Autophagy20110701
Title: A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate.
Journal: American journal of physiology. Renal physiology20110701
Title: Reduction of the peripheral blood CD56(bright) NK lymphocyte subset in FTY720-treated multiple sclerosis patients.
Journal: Journal of immunology (Baltimore, Md. : 1950)20110701
Title: Discovery of S1P agonists with a dihydronaphthalene scaffold.
Journal: Bioorganic & medicinal chemistry letters20110701
Title: The emerging role of Brazil in clinical trial conduct for transplantation.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20110701
Title: Sphingosine 1-phosphate receptor modulator FTY720 suppresses rat experimental autoimmune prostatitis.
Journal: Scandinavian journal of immunology20110601
Title: Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.
Journal: Hepatology (Baltimore, Md.)20110601
Title: New drugs 2011 part 2.
Journal: Nursing20110601
Title: Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.
Journal: The Journal of clinical investigation20110601
Title: Transforming multiple sclerosis trials into practical reality.
Journal: The Lancet. Neurology20110601
Title: Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study.
Journal: The Lancet. Neurology20110601
Title: Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose fingolimod (FTY720) in adolescents with stable renal transplants.
Journal: Pediatric transplantation20110601
Title: [Influence of PP2A activator on proliferation of HL-60 cells and analysis of PP2A activity changes in patients with acute myeloid leukemia].
Journal: Zhongguo shi yan xue ye xue za zhi20110601
Title: FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
Journal: The Journal of biological chemistry20110527
Title: [Development of new therapies for multiple sclerosis].
Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke20110506
Title: Magnetic resonance imaging as surrogate for clinical endpoints in multiple sclerosis: data on novel oral drugs.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20110501
Title: Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20110501
Title: Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.
Journal: Kidney international20110501
Title: Managing MS in a changing treatment landscape.
Journal: Journal of neurology20110501
Title: Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.
Journal: Annals of neurology20110501
Title: American academy of neurology annual meeting.
Journal: International MS journal20110501
Title: Functional improvement and symptom management in multiple sclerosis: clinical efficacy of current therapies.
Journal: The American journal of managed care20110501
Title: Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite.
Journal: Journal of natural products20110425
Title: Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720.
Journal: The Journal of biological chemistry20110422
Title: Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS.
Journal: Neurology20110405
Title: BZM055, an iodinated radiotracer candidate for PET and SPECT imaging of myelin and FTY720 brain distribution.
Journal: ChemMedChem20110404
Title: Sphingosine kinase and sphingosine 1-phosphate in asthma.
Journal: Bioscience reports20110401
Title: Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis.
Journal: Advances in therapy20110401
Title: Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis.
Journal: The American journal of pathology20110401
Title: Clarity and strength of implications for practice in medical journal articles: an exploratory analysis.
Journal: BMJ quality & safety20110401
Title: Effects of low dose methotrexate on relapsing-remitting multiple sclerosis in comparison to Interferon β-1α: A randomized controlled trial.
Journal: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences20110401
Title: In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates.
Journal: Fertility and sterility20110315
Title: Primary varicella zoster infection associated with fingolimod treatment.
Journal: Neurology20110315
Title: Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers -- Letter.
Journal: Cancer research20110315
Title: Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells.
Journal: Autoimmunity20110301
Title: Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth.
Journal: Tissue engineering. Part A20110301
Title: Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis.
Journal: International immunopharmacology20110301
Title: Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator.
Journal: Biochemical pharmacology20110301
Title: The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue.
Journal: Experimental dermatology20110301
Title: Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety.
Journal: Bioorganic & medicinal chemistry letters20110301
Title: Principles of a new treatment algorithm in multiple sclerosis.
Journal: Expert review of neurotherapeutics20110301
Title: Depressogenic effects of medications: a review.
Journal: Dialogues in clinical neuroscience20110301
Title: Embryonic pig pancreatic tissue for the treatment of diabetes: potential role of immune suppression with 'off-the-shelf' third-party regulatory T cells.
Journal: Transplantation20110227
Title: Impact of sphingosine 1-phosphate modulation on immune outcomes.
Journal: Neurology20110222
Title: Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis.
Journal: Neurology20110222
Title: Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy.
Journal: Neurology20110222
Title: Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.
Journal: Neurology20110222
Title: The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.
Journal: Neurology20110222
Title: Modulation of sphingosine 1-phosphate signaling in neurologic disease.
Journal: Neurology20110222
Title: Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis.
Journal: Circulation research20110204
Title: [Oral fingolimod in multiple sclerosis: therapeutic modulation of the sphingosine-1-phosphate system].
Journal: Der Nervenarzt20110201
Title: Emerging disease-modifying oral therapies for multiple sclerosis.
Journal: Journal of neuroimmunology20110201
Title: Autoimmune uveitis: the associated proinflammatory molecules and the search for immunoregulation.
Journal: Autoimmunity reviews20110201
Title: Roles for lysophospholipid S1P receptors in multiple sclerosis.
Journal: Critical reviews in biochemistry and molecular biology20110201
Title: Absorption and disposition of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in healthy volunteers: a case of xenobiotic biotransformation following endogenous metabolic pathways.
Journal: Drug metabolism and disposition: the biological fate of chemicals20110201
Title: CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.
Journal: Drug metabolism and disposition: the biological fate of chemicals20110201
Title: Fingolimod for the treatment of relapsing multiple sclerosis.
Journal: Expert review of neurotherapeutics20110201
Title: Systemic influence of immunosuppressive drugs on small and large bowel transport and barrier function.
Journal: Transplant international : official journal of the European Society for Organ Transplantation20110201
Title: Multiple sclerosis in 2010: Advances in monitoring and treatment of multiple sclerosis.
Journal: Nature reviews. Neurology20110201
Title: Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients.
Journal: Annals of neurology20110201
Title: [Current treatment of multiple sclerosis].
Journal: Lege artis medicinae : uj magyar orvosi hirmondo20110201
Title: The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.
Journal: The Journal of biological chemistry20110121
Title: Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.
Journal: Biochemical and biophysical research communications20110107
Title: CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20110101
Title: Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal.
Journal: Analytical biochemistry20110101
Title: Differential responses of human microglia and blood-derived myeloid cells to FTY720.
Journal: Journal of neuroimmunology20110101
Title: Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs.
Journal: Molecular pharmacology20110101
Title: Oral therapies for multiple sclerosis: a review of agents in phase III development or recently approved.
Journal: CNS drugs20110101
Title: Therapeutic approach to multiple sclerosis by novel oral drug.
Journal: Recent patents on inflammation & allergy drug discovery20110101
Title: New drugs: dabigatran etexilate mesylate, fingolimod hydrochloride, and ulipristal acetate.
Journal: Journal of the American Pharmacists Association : JAPhA20110101
Title: Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls.
Journal: Current topics in medicinal chemistry20110101
Title: Use of an online community to develop patient-reported outcome instruments: the Multiple Sclerosis Treatment Adherence Questionnaire (MS-TAQ).
Journal: Journal of medical Internet research20110101
Title: Fingolimod provides long-term protection in rodent models of cerebral ischemia.
Journal: Annals of neurology20110101
Title: [Immunosuppressive agents in kidney transplantation].
Journal: Nihon Jinzo Gakkai shi20110101
Title: Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice.
Journal: Experimental & translational stroke medicine20110101
Title: Current disease-modifying treatment of multiple sclerosis.
Journal: The Mount Sinai journal of medicine, New York20110101
Title: Multiple sclerosis therapeutic pipeline: opportunities and challenges.
Journal: The Mount Sinai journal of medicine, New York20110101
Title: Patient considerations in the management of multiple sclerosis: development and clinical utility of oral agents.
Journal: Patient preference and adherence20110101
Title: Evidence-based assessment of potential use of fingolimod in treatment of relapsing multiple sclerosis.
Journal: Core evidence20110101
Title: Lights and shadows of cyclophosphamide in the treatment of multiple sclerosis.
Journal: Autoimmune diseases20110101
Title: S1P is associated with protection in human and experimental cerebral malaria.
Journal: Molecular medicine (Cambridge, Mass.)20110101
Title: Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
Journal: PloS one20110101
Title: Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice.
Journal: PloS one20110101
Title: When neurologist and patient disagree on reasonable risk: new challenges in prescribing for patients with multiple sclerosis.
Journal: Neuropsychiatric disease and treatment20110101
Title: Development of oral immunomodulatory agents in the management of multiple sclerosis.
Journal: Drug design, development and therapy20110101
Title: Relapse of experimental autoimmune encephalomyelitis after discontinuation of FTY720 (Fingolimod) treatment, but not after combination of FTY720 and pathogenic autoantigen.
Journal: Biological & pharmaceutical bulletin20110101
Title: Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.
Journal: PloS one20110101
Title: Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects.
Journal: Frontiers in pharmacology20110101
Title: Selectivity and specificity of sphingosine 1-phosphate receptor ligands: 'off-targets' or complex pharmacology?
Journal: Frontiers in pharmacology20110101
Title: FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
Journal: PloS one20110101
Title: Fingolimod (FTY720): First approved oral therapy for multiple sclerosis.
Journal: Journal of pharmacology & pharmacotherapeutics20110101
Title: Placebo - More hatred than love.
Journal: Journal of neurosciences in rural practice20110101
Title: FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice.
Journal: Acta neurochirurgica. Supplement20110101
Title: Fingolimod modulates microglial activation to augment markers of remyelination.
Journal: Journal of neuroinflammation20110101
Title: Fingolimod.
Journal: Prescrire international20110101
Title: Cost-effectiveness of natalizumab versus fingolimod for the treatment of relapsing multiple sclerosis.
Journal: Journal of medical economics20110101
Title: The effects of omega-3 Fatty acids on matrix metalloproteinase-9 production and cell migration in human immune cells: implications for multiple sclerosis.
Journal: Autoimmune diseases20110101
Title: A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders.
Journal: PloS one20110101
Title: Novel therapeutic approaches to autoimmune demyelinating disorders.
Journal: Current pharmaceutical design20110101
Title: Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis.
Journal: ASN neuro20110101
Title: Author's Reply.
Journal: Journal of pharmacology & pharmacotherapeutics20110101
Title: Fingolimod (Gileyna, FTY720): Innovative treatment for multiple sclerosis.
Journal: Journal of pharmacology & pharmacotherapeutics20110101
Title: [A plan for risk management in the treatment of multiple sclerosis with gilenia (fingolimod)].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova20110101
Title: Critical appraisal of the role of fingolimod in the treatment of multiple sclerosis.
Journal: Neuropsychiatric disease and treatment20110101
Title: Therapeutic effects of novel sphingosine-1-phosphate receptor agonist W-061 in murine DSS colitis.
Journal: PloS one20110101
Title: Fingolimod: The first oral drug approved by food and drug administration; A breakthrough in treatment of multiple sclerosis.
Journal: Journal of pharmacy & bioallied sciences20110101
Title: Disease-modifying drug initiation patterns in commercially insured multiple sclerosis patients: a retrospective cohort study.
Journal: BMC neurology20110101
Title: When to initiate disease-modifying drugs for relapsing remitting multiple sclerosis in adults?
Journal: Multiple sclerosis international20110101
Title: Optimal deconvolution of transcriptional profiling data using quadratic programming with application to complex clinical blood samples.
Journal: PloS one20110101
Title: Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis.
Journal: Journal of signal transduction20110101
Title: Establishing long-term efficacy in chronic disease: use of recursive partitioning and propensity score adjustment to estimate outcome in MS.
Journal: PloS one20110101
Title: The immunosuppressant FTY720 (fingolimod) enhances glycosaminoglycan depletion in articular cartilage.
Journal: BMC musculoskeletal disorders20110101
Title: Where are the new medicines? The case for terrestrial microorganisms.
Journal: Journal of advanced pharmaceutical technology & research20110101
Title: Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats.
Journal: PloS one20110101
Title: Reassessment of blood gene expression markers for the prognosis of relapsing-remitting multiple sclerosis.
Journal: PloS one20110101
Title: Short-Term Relapse Quantitation as a Fully Surrogate Endpoint for Long-Term Sustained Progression of Disability in RRMS Patients Treated with Natalizumab.
Journal: Neurology research international20110101
Title: Modeling natural anti-inflammatory compounds by molecular topology.
Journal: International journal of molecular sciences20110101
Title: Oral fingolimod (gilenya) for multiple sclerosis.
Journal: The Medical letter on drugs and therapeutics20101229
Title: Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.
Journal: American journal of respiratory cell and molecular biology20101201
Title: Effects of different dose of FTY720 on lymphocyte cell cycle arrest in cardiac transplantation model of rats.
Journal: Immunopharmacology and immunotoxicology20101201
Title: Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival.
Journal: Transplant international : official journal of the European Society for Organ Transplantation20101201
Title: T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract.
Journal: Nature medicine20101201
Title: Understanding the effects of FTY720 on leukocyte trafficking.
Journal: Archives of neurology20101201
Title: Distinct properties of circulating CD8+ T cells in FTY720-treated patients with multiple sclerosis.
Journal: Archives of neurology20101201
Title: Effect of FTY720 treatment on postischemic pancreatic microhemodynamics.
Journal: Transplantation proceedings20101201
Title: FDA approves the first oral drug for reducing multiple sclerosis relapses.
Journal: Harvard women's health watch20101201
Title: Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
Journal: The Journal of biological chemistry20101112
Title: FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.
Journal: Autophagy20101101
Title: FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
Journal: Cancer research20101101
Title: Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.
Journal: Nature reviews. Drug discovery20101101
Title: Novartis eyes oral MS drug as potential blockbuster.
Journal: Nature biotechnology20101101
Title: [Role of T lymphocytes in ischemic brain injury].
Journal: Rinsho shinkeigaku = Clinical neurology20101101
Title: Design and synthesis of selective and potent orally active S1P5 agonists.
Journal: ChemMedChem20101004
Title: (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.
Journal: Cellular signalling20101001
Title: FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Journal: Cellular signalling20101001
Title: Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients.
Journal: Clinical immunology (Orlando, Fla.)20101001
Title: Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate.
Journal: Molecular pharmacology20101001
Title: FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice.
Journal: The American journal of pathology20101001
Title: Current and future role of interferon beta in the therapy of multiple sclerosis.
Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research20101001
Title: Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis.
Journal: Archives of pharmacal research20101001
Title: Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Journal: Cellular signalling20100901
Title: Emerging therapies in relapsing-remitting multiple sclerosis.
Journal: Reviews on recent clinical trials20100901
Title: PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.
Journal: Journal of cellular biochemistry20100901
Title: Emerging oral therapies in multiple sclerosis.
Journal: Current neurology and neuroscience reports20100901
Title: A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination.
Journal: European journal of immunology20100901
Title: The enhancement of bone allograft incorporation by the local delivery of the sphingosine 1-phosphate receptor targeted drug FTY720.
Journal: Biomaterials20100901
Title: Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions.
Journal: Glia20100901
Title: Treatment options for multiple sclerosis: current and emerging therapies.
Journal: Pharmacotherapy20100901
Title: Emerging oral agents for multiple sclerosis.
Journal: The American journal of managed care20100901
Title: Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies.
Journal: Current neuropharmacology20100901
Title: Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis.
Journal: Neurology20100803
Title: FTY720 and central memory: out of sight, out of mind.
Journal: Neurology20100803
Title: Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
Journal: The Journal of experimental medicine20100802
Title: Effect of combined treatment with FK506, FTY720, and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Pediatric transplantation20100801
Title: Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model.
Journal: Clinical immunology (Orlando, Fla.)20100801
Title: Treating multiple sclerosis with fingolimod or intramuscular interferon.
Journal: Expert opinion on pharmacotherapy20100801
Title: Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation.
Journal: Endocrinology20100801
Title: FTY720 mediates cytochrome c release from mitochondria during rat thymocyte apoptosis.
Journal: Transplant immunology20100801
Title: Update on emerging therapies for multiple sclerosis.
Journal: Expert review of neurotherapeutics20100801
Title: Avoiding infusion therapy prime benefit of new MS drug.
Journal: Managed care (Langhorne, Pa.)20100801
Title: Oral fingolimod for relapsing-remitting multiple sclerosis Evaluation of: Kappos L, Radue E-M, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401; and Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402-15.
Journal: Expert opinion on pharmacotherapy20100701
Title: Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.
Journal: Brain : a journal of neurology20100701
Title: Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers.
Journal: Cancer research20100701
Title: Fingolimod is a potential novel therapy for multiple sclerosis.
Journal: Nature reviews. Neurology20100701
Title: Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion.
Journal: British journal of pharmacology20100701
Title: S1P(1) receptor agonists: Assessment of selectivity and current clinical activity.
Journal: Current opinion in drug discovery & development20100701
Title: [Fingolimod in the treatment of multiple sclerosis. Novelties presented at the annual congress of the American Academy of Neurology (Toronto, April 2010)].
Journal: Drugs of today (Barcelona, Spain : 1998)20100701
Title: FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20100615
Title: Critical vasospasm during fingolimod (FTY720) treatment in a patient with multiple sclerosis.
Journal: Neurology20100615
Title: [Emerging treatments for multiple sclerosis].
Journal: Revue medicale suisse20100602
Title: FTY720 promotes local microvascular network formation and regeneration of cranial bone defects.
Journal: Tissue engineering. Part A20100601
Title: Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs.
Journal: Diabetes20100601
Title: Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.
Journal: Journal of the American Society of Nephrology : JASN20100601
Title: The impact of fingolimod (FTY720) in neuroimmunologic diseases: mechanisms beyond immunomodulation.
Journal: The American journal of pathology20100601
Title: Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices.
Journal: The American journal of pathology20100601
Title: New drug therapies for multiple sclerosis.
Journal: Current opinion in neurology20100601
Title: Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.
Journal: International immunology20100601
Title: ACP Journal Club. Oral fingolimod was more effective than intramuscular interferon for relapsing-remitting multiple sclerosis.
Journal: Annals of internal medicine20100518
Title: ACP Journal Club. Oral fingolimod was more effective than placebo for relapsing-remitting multiple sclerosis.
Journal: Annals of internal medicine20100518
Title: Oral cladribine and fingolimod for relapsing multiple sclerosis.
Journal: The New England journal of medicine20100506
Title: Oral cladribine and fingolimod for relapsing multiple sclerosis.
Journal: The New England journal of medicine20100506
Title: Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
Journal: Transplant international : official journal of the European Society for Organ Transplantation20100501
Title: Evaluation of experimental autoimmune uveitis in mice treated with FTY720.
Journal: Investigative ophthalmology & visual science20100501
Title: Fingolimod for relapsing multiple sclerosis: an update.
Journal: Expert opinion on pharmacotherapy20100501
Title: Oral fingolimod for the treatment of relapsing-remitting multiple sclerosis.
Journal: Drugs of today (Barcelona, Spain : 1998)20100501
Title: Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.
Journal: Journal of medicinal chemistry20100422
Title: FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.
Journal: Biochemical and biophysical research communications20100409
Title: FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release.
Journal: Cancer immunology, immunotherapy : CII20100401
Title: Targeting the sphingolipid signaling pathway in stroke.
Journal: Stroke20100401
Title: Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.
Journal: Bioorganic & medicinal chemistry letters20100401
Title: [How rare is tuberculosis?].
Journal: Medizinische Monatsschrift fur Pharmazeuten20100401
Title: [Development of oral therapies for multiple sclerosis--fingolimod, cladribine and other drugs].
Journal: Medizinische Monatsschrift fur Pharmazeuten20100401
Title: Current and future disease-modifying therapies in multiple sclerosis.
Journal: International journal of clinical practice20100401
Title: Multiple sclerosis: closing in on an oral treatment.
Journal: Nature20100318
Title: FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
Journal: Circulation research20100305
Title: [Progress of therapy in patients with multiple sclerosis].
Journal: MMW Fortschritte der Medizin20100304
Title: United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology20100301
Title: Discovery of a novel series of potent S1P1 agonists.
Journal: Bioorganic & medicinal chemistry letters20100301
Title: S1P receptor mediated activity of FTY720 phosphate mimics.
Journal: Bioorganic & medicinal chemistry letters20100301
Title: New drugs may improve, complicate treatment for multiple sclerosis.
Journal: Nature medicine20100301
Title: Multiple sclerosis - established and novel therapeutic approaches.
Journal: Central nervous system agents in medicinal chemistry20100301
Title: Cell phenotype evaluation at various sites after skin transplantation and FTY720 plus sirolimus therapy.
Journal: Transplantation proceedings20100301
Title: Leishmania (Leishmania) amazonensis infection in mice treated with FTY720.
Journal: Transplantation proceedings20100301
Title: Sirolimus in combination with FTY720: analysis of urinary and serum parameters.
Journal: Transplantation proceedings20100301
Title: Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants.
Journal: Transplantation20100227
Title: Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection.
Journal: Virology20100220
Title: Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.
Journal: American journal of respiratory and critical care medicine20100215
Title: A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis.
Journal: The New England journal of medicine20100204
Title: Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.
Journal: The New England journal of medicine20100204
Title: Oral therapy for multiple sclerosis--sea change or incremental step?
Journal: The New England journal of medicine20100204
Title: FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses.
Journal: Journal of neuroscience research20100201
Title: FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.
Journal: Journal of molecular and cellular cardiology20100201
Title: Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.
Journal: Stroke20100201
Title: Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England)20100201
Title: Emerging multiple sclerosis oral therapies.
Journal: Neurology20100105
Title: A functional role for CCR6 on proallergic T cells in the gastrointestinal tract.
Journal: Gastroenterology20100101
Title: FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration.
Journal: Laboratory investigation; a journal of technical methods and pathology20100101
Title: Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis.
Journal: Clinical neuropharmacology20100101
Title: [FTY720-induced lymphocyte apoptosis inhibits acute graft versus host disease in rat small bowel transplantation].
Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery20100101
Title: Role of platelets in neuroinflammation: a wide-angle perspective.
Journal: Journal of neuroinflammation20100101
Title: Optimizing the benefit of multiple sclerosis therapy: the importance of treatment adherence.
Journal: Patient preference and adherence20100101
Title: A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow.
Journal: PloS one20100101
Title: Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.
Journal: Arthritis research & therapy20100101
Title: Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis.
Journal: Therapeutics and clinical risk management20100101
Title: Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20100101
Title: Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20100101
Title: Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.
Journal: PloS one20100101
Title: Arthritis: where are the T cells?
Journal: Arthritis research & therapy20100101
Title: Identification of targets and new developments in the treatment of multiple sclerosis--focus on cladribine.
Journal: Drug design, development and therapy20100101
Title: Multiple sclerosis therapies: molecular mechanisms and future.
Journal: Results and problems in cell differentiation20100101
Title: Disease-modifying therapies in relapsing-remitting multiple sclerosis.
Journal: Neuropsychiatric disease and treatment20100101
Title: Emerging oral treatments in multiple sclerosis - clinical utility of cladribine tablets.
Journal: Therapeutics and clinical risk management20100101
Title: Innate pathways of immune activation in transplantation.
Journal: Journal of transplantation20100101
Title: Altered expression of signaling genes in Jurkat cells upon FTY720 induced apoptosis.
Journal: International journal of molecular sciences20100101
Title: Potential short-term use of oral cladribine in treatment of relapsing-remitting multiple sclerosis.
Journal: Neuropsychiatric disease and treatment20100101
Title: FTY720-induced suicidal erythrocyte death.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology20100101
Title: New approaches in the management of multiple sclerosis.
Journal: Drug design, development and therapy20100101
Title: Disease modifying agents for multiple sclerosis.
Journal: The open neurology journal20100101
Title: Emerging therapies for treatment of multiple sclerosis.
Journal: Journal of inflammation research20100101
Title: Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720.
Journal: Pathology oncology research : POR20091201
Title: FTY720 reduces inflammation and promotes functional recovery after spinal cord injury.
Journal: Journal of neurotrauma20091201
Title: T-cell activation in ischemic stroke: a new therapeutic target for delayed infarct expansion?
Journal: Neurosurgery20091201
Title: Treatment with immunosuppressants FTY720 and tacrolimus promotes functional recovery after spinal cord injury in rats.
Journal: The Tohoku journal of experimental medicine20091201
Title: Systemically circulating colitogenic memory CD4+T cells may be an ideal target for the treatment of inflammatory bowel diseases.
Journal: The Keio journal of medicine20091201
Title: The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.
Journal: Biochemical and biophysical research communications20091113
Title: Activation of the lung S1P(1) receptor reduces allergen-induced plasma leakage in mice.
Journal: British journal of pharmacology20091101
Title: FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.
Journal: British journal of pharmacology20091101
Title: [Multiple sclerosis, the therapeutic arsenal of today and tomorrow].
Journal: Soins; la revue de reference infirmiere20091101
Title: News & views in ... Immunotherapy.
Journal: Immunotherapy20091101
Title: Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog.
Journal: Transplantation20091027
Title: T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
Journal: The Journal of experimental medicine20091026
Title: FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis.
Journal: Neuropathology and applied neurobiology20091001
Title: Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro.
Journal: The Journal of pharmacology and experimental therapeutics20091001
Title: Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2.
Journal: Stroke20091001
Title: Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.
Journal: American journal of physiology. Cell physiology20091001
Title: The future of multiple sclerosis therapy.
Journal: Pharmacological research20091001
Title: Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection.
Journal: Journal of immunology (Baltimore, Md. : 1950)20091001
Title: [Fingolimod - a new immunomodulator].
Journal: Deutsche medizinische Wochenschrift (1946)20091001
Title: New oral drugs for multiple sclerosis.
Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology20091001
Title: Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy.
Journal: Journal of neuroimmunology20090929
Title: The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo.
Journal: Journal of immunology (Baltimore, Md. : 1950)20090915
Title: Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats.
Journal: American journal of physiology. Renal physiology20090901
Title: Fragile maintenance of allograft tolerance induced by lymphocyte sequestration and co-stimulation blockade.
Journal: Transplant immunology20090901
Title: [Role of sphingosine 1-phosphate receptor signaling in hematopoietic stem/progenitor cell transmigration].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University20090901
Title: Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs.
Journal: Bioorganic & medicinal chemistry20090815
Title: Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.
Journal: The Journal of investigative dermatology20090801
Title: Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.
Journal: The Journal of investigative dermatology20090801
Title: [Molecular target drug development for curing multiple sclerosis].
Journal: Brain and nerve = Shinkei kenkyu no shinpo20090801
Title: Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.
Journal: Cardiovascular research20090715
Title: Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.
Journal: Journal of medicinal chemistry20090709
Title: Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression.
Journal: Diabetes20090701
Title: The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy.
Journal: American journal of physiology. Renal physiology20090701
Title: Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20090701
Title: Immunomodulatory drug FTY720 induces regulatory CD4(+)CD25(+) T cells in vitro.
Journal: Clinical and experimental immunology20090701
Title: Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.
Journal: The Journal of biological chemistry20090612
Title: Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.
Journal: Neuron20090611
Title: FTY720 and lung tumor development.
Journal: International immunopharmacology20090601
Title: Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Journal: Nature chemical biology20090601
Title: [New therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20090601
Title: Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.
Journal: Pathology international20090601
Title: [FTY720 reduces peritubular micrangium loss in renal interstitial fibrotic rats].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics20090601
Title: Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
Journal: Anti-cancer agents in medicinal chemistry20090501
Title: Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.
Journal: The Journal of organic chemistry20090417
Title: Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.
Journal: Bioorganic & medicinal chemistry letters20090415
Title: FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage.
Journal: Brain pathology (Zurich, Switzerland)20090401
Title: Immunosuppressive therapy and post-transplant malignancy.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20090401
Title: Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques.
Journal: The Journal of antimicrobial chemotherapy20090401
Title: Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond.
Journal: European journal of immunology20090401
Title: Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice.
Journal: Cell biology international20090401
Title: [A new therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)].
Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology20090401
Title: Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.
Journal: Nature20090326
Title: B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.
Journal: Immunity20090320
Title: Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: a case report.
Journal: Neurology20090317
Title: Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy.
Journal: The Journal of pharmacology and experimental therapeutics20090301
Title: Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats.
Journal: Experimental neurology20090301
Title: FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.
Journal: Transplantation proceedings20090301
Title: FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
Journal: The Journal of biological chemistry20090227
Title: Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition.
Journal: Journal of clinical pharmacology20090201
Title: Trial watch: Phase III promise for oral multiple sclerosis therapy.
Journal: Nature reviews. Drug discovery20090201
Title: [An additional role of FTY720 in chronic colitis].
Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology20090201
Title: [Therapeutic advances in neurology].
Journal: Revue medicale suisse20090107
Title: Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study.
Journal: Neurology20090106
Title: The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: how a bioactive lipid mediator grew up from an 'immature' vascular maturation factor to a 'mature' mediator of lymphocyte behavior and function.
Journal: Immunologic research20090101
Title: Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Journal: Kidney international20090101
Title: An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammation.
Journal: Clinical and experimental immunology20090101
Title: Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures.
Journal: Journal of neuroinflammation20090101
Title: [Lysophospholipid mediators].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme20090101
Title: T regulatory cells: an overview and intervention techniques to modulate allergy outcome.
Journal: Clinical and molecular allergy : CMA20090101
Title: The influence of commonly used immunosuppressive drugs on the small bowel functions - a comparative experimental study.
Journal: Annals of transplantation20090101
Title: Review of teriflunomide and its potential in the treatment of multiple sclerosis.
Journal: Neuropsychiatric disease and treatment20090101
Title: Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects.
Journal: Arthritis research & therapy20090101
Title: FTY720 and everolimus in de novo renal transplant patients at risk for delayed graft function: results of an exploratory one-yr multicenter study.
Journal: Clinical transplantation20090101
Title: Recent developments in multiple sclerosis therapeutics.
Journal: BMC medicine20090101
Title: Promising treatments of tomorrow for multiple sclerosis.
Journal: Annals of Indian Academy of Neurology20090101
Title: New oral disease-modifying therapies for multiple sclerosis.
Journal: F1000 medicine reports20090101
Title: Assessing cost-effectiveness in the management of multiple sclerosis.
Journal: ClinicoEconomics and outcomes research : CEOR20090101
Title: Impaired initiation of contact hypersensitivity by FTY720.
Journal: The Journal of investigative dermatology20081201
Title: FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.
Journal: European journal of immunology20081201
Title: Treatment of chronic allograft nephropathy at late stages using everolimus or FTY720 in combination with cyclosporine.
Journal: Transplantation proceedings20081201
Title: Central nervous system-directed effects of FTY720 (fingolimod).
Journal: Journal of the neurological sciences20081115
Title: Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies.
Journal: Clinical neurology and neurosurgery20081101
Title: Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival.
Journal: Transplant immunology20081101
Title: A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis.
Journal: Brain : a journal of neurology20081101
Title: A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
Journal: Biochemical and biophysical research communications20081031
Title: FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis.
Journal: Neurology20081014
Title: Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod.
Journal: The American journal of pathology20081001
Title: The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase.
Journal: The Journal of infectious diseases20081001
Title: Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960)20081001
Title: FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice.
Journal: Diabetes, obesity & metabolism20080901
Title: Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.
Journal: Biochimica et biophysica acta20080901
Title: Sphingosine 1-phosphate chemical biology.
Journal: Biochimica et biophysica acta20080901
Title: Emerging oral drugs for multiple sclerosis.
Journal: Expert opinion on emerging drugs20080901
Title: TX-2152: a conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity.
Journal: Bioorganic & medicinal chemistry20080815
Title: Immunology: Surprising side effects.
Journal: Nature20080814
Title: Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection.
Journal: Nature20080814
Title: The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects.
Journal: British journal of clinical pharmacology20080801
Title: Infections cast cloud over Novartis' MS therapy.
Journal: Nature biotechnology20080801
Title: Azathioprine in multiple sclerosis.
Journal: Mini reviews in medicinal chemistry20080801
Title: Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype.
Journal: The Journal of investigative dermatology20080701
Title: Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues.
Journal: ChemMedChem20080701
Title: Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P.
Journal: Genes to cells : devoted to molecular & cellular mechanisms20080701
Title: FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression.
Journal: Biochemical and biophysical research communications20080613
Title: Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury.
Journal: Neuropathology and applied neurobiology20080601
Title: Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators.
Journal: Journal of immunology (Baltimore, Md. : 1950)20080601
Title: Antinociceptive activity of the S1P-receptor agonist FTY720.
Journal: Journal of cellular and molecular medicine20080601
Title: Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
Journal: Biological & pharmaceutical bulletin20080601
Title: [Overview of MS: proposal of new MS definition/classification and review of the results of recent clinical trials].
Journal: Nihon rinsho. Japanese journal of clinical medicine20080601
Title: 'Inside-out' signaling of sphingosine-1-phosphate: therapeutic targets.
Journal: Pharmacological reviews20080601
Title: Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients.
Journal: Transplantation proceedings20080601
Title: Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro.
Journal: Transplantation proceedings20080601
Title: New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Journal: Biochemical pharmacology20080515
Title: The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects.
Journal: European journal of clinical pharmacology20080501
Title: Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.
Journal: International immunology20080501
Title: FTY720 (fingolimod) for relapsing multiple sclerosis.
Journal: Expert review of neurotherapeutics20080501
Title: The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen.
Journal: Journal of immunology (Baltimore, Md. : 1950)20080415
Title: Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.
Journal: Journal of immunology (Baltimore, Md. : 1950)20080415
Title: FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves.
Journal: Experimental neurology20080401
Title: Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis.
Journal: Pancreas20080401
Title: Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).
Journal: Chemical & pharmaceutical bulletin20080401
Title: Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice.
Journal: Transplantation proceedings20080401
Title: Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures.
Journal: Biochimica et biophysica acta20080301
Title: A mechanistic study to assess whether isoproterenol can reverse the negative chronotropic effect of fingolimod.
Journal: Journal of clinical pharmacology20080301
Title: [Therapeutic effect of S1P receptor modifying drugs for autoimmune diseases].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica20080301
Title: FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.
Journal: Cancer research20080215
Title: Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii.
Journal: Archives of pharmacal research20080201
Title: FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.
Journal: Blood20080101
Title: FTY720 modulates human oligodendrocyte progenitor process extension and survival.
Journal: Annals of neurology20080101
Title: Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis.
Journal: Pharmacology & therapeutics20080101
Title: Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.
Journal: British journal of pharmacology20080101
Title: Follicular shuttling of marginal zone B cells facilitates antigen transport.
Journal: Nature immunology20080101
Title: The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.
Journal: Nature immunology20080101
Title: Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Surgery today20080101
Title: Antibody-mediated rejection with a striking interstitial monocyte/macrophage infiltration in a renal allograft under FTY720 treatment.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation20080101
Title: Reversible cystoid macular edema secondary to fingolimod in a renal transplant recipient.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960)20080101
Title: Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.
Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques20080101
Title: FTY720 treatment in experimentally urethane-induced lung tumors.
Journal: Journal of experimental therapeutics & oncology20080101
Title: Recent trials for FTY720 (fingolimod): a new generation of immunomodulators structurally similar to sphingosine.
Journal: Reviews on recent clinical trials20080101
Title: Neurotherapeutics in multiple sclerosis: novel agents and emerging treatment strategies.
Journal: The Mount Sinai journal of medicine, New York20080101
Title: Cell cycle arrest effects of large-dose FTY720 on lymphocytes in mouse skin transplantation models.
Journal: Immunopharmacology and immunotoxicology20080101
Title: Disease-modifying agents for multiple sclerosis: recent advances and future prospects.
Journal: Drugs20080101
Title: [Cordyceps sinensis, a fungi used in the Chinese traditional medicine].
Journal: Revista iberoamericana de micologia20071231
Title: Evaluation of stem cell administration in a model of kidney ischemia-reperfusion injury.
Journal: International immunopharmacology20071215
Title: Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist.
Journal: Journal of medicinal chemistry20071213
Title: [Regulation of immunity by sphingosine 1-phosphate and its G protein-coupled receptors--review].
Journal: Zhongguo shi yan xue ye xue za zhi20071201
Title: FTY720 reduces extracellular matrix expansion associated with ischemia-reperfusion induced injury.
Journal: Transplantation proceedings20071201
Title: Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: apoptosis of crypt cells and lymphocytes.
Journal: Transplantation proceedings20071201
Title: Therapeutic targeting of leukocyte trafficking across the blood-brain barrier.
Journal: Inflammation & allergy drug targets20071201
Title: [Effect of FTY720 on glomerulosclerosis and expression of cell cycle regulatory proteins in subtotally nephrectomized rats].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics20071201
Title: Reduction of CD4 positive T cells and improvement of pathological changes of collagen-induced arthritis by FTY720.
Journal: European journal of pharmacology20071114
Title: Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).
Journal: Blood20071101
Title: Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis.
Journal: The Journal of pharmacology and experimental therapeutics20071101
Title: The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
Journal: The Journal of pharmacology and experimental therapeutics20071101
Title: Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology20071101
Title: Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.
Journal: Journal of immunology (Baltimore, Md. : 1950)20071101
Title: Synthesis and spectral properties of cholesterol- and FTY720-containing boron dipyrromethene dyes.
Journal: The Journal of organic chemistry20071026
Title: FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis.
Journal: Brain research bulletin20071019
Title: FTY720 versus mycophenolate mofetil in de novo renal transplantation: six-month results of a double-blind study.
Journal: Transplantation20071015
Title: [FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis].
Journal: Der Nervenarzt20071001
Title: Fingolimod: a novel immunosuppressant for multiple sclerosis.
Journal: The Annals of pharmacotherapy20071001
Title: The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers.
Journal: Transplant international : official journal of the European Society for Organ Transplantation20071001
Title: Emerging therapies for multiple sclerosis.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics20071001
Title: Effect of FTY720 on apoptosis of smooth muscle cells.
Journal: Transplantation proceedings20071001
Title: FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells.
Journal: Cancer letters20070908
Title: FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
Journal: The Journal of clinical investigation20070904
Title: Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20070901
Title: Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor.
Journal: Cellular signalling20070801
Title: Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.
Journal: Journal of neurochemistry20070801
Title: The impact of FTY720 (fingolimod) on vasodilatory function and arterial elasticity in renal transplant patients.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20070801
Title: Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20070801
Title: Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy.
Journal: Journal of immunology (Baltimore, Md. : 1950)20070801
Title: FTY720: a most promising immunosuppressant modulating immune cell functions.
Journal: Mini reviews in medicinal chemistry20070801
Title: FTY720 improves survival after transient ischemia and reperfusion of the hind limbs.
Journal: The Journal of trauma20070801
Title: The immunomodulator FTY720 is phosphorylated and released from platelets.
Journal: European journal of pharmacology20070730
Title: Reduction of ischemia-reperfusion injury in the rat kidney by FTY720, a synthetic derivative of sphingosine.
Journal: Transplantation20070727
Title: FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Journal: Molecular immunology20070701
Title: Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors.
Journal: Naunyn-Schmiedeberg's archives of pharmacology20070701
Title: Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.
Journal: Pharmacology & therapeutics20070701
Title: FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.
Journal: FEBS letters20070626
Title: S1P modulator FTY720 limits matrix expansion in acute anti-thy1 mesangioproliferative glomerulonephritis.
Journal: American journal of physiology. Renal physiology20070601
Title: The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma.
Journal: International immunology20070601
Title: Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis.
Journal: Expert opinion on pharmacotherapy20070601
Title: Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
Journal: The Journal of biological chemistry20070525
Title: The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.
Journal: Journal of cellular biochemistry20070501
Title: Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.
Journal: Blood20070501
Title: Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.
Journal: Journal of immunology (Baltimore, Md. : 1950)20070501
Title: Novel oral agents for multiple sclerosis.
Journal: Current neurology and neuroscience reports20070501
Title: Immunology. The sources of a lipid conundrum.
Journal: Science (New York, N.Y.)20070413
Title: Mechanism of mitochondrial 7A6 antigen exposure triggered by distinct apoptotic pathways: involvement of caspases.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20070401
Title: FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.
Journal: British journal of pharmacology20070401
Title: Current perspectives on FTY720.
Journal: Expert opinion on investigational drugs20070401
Title: Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors.
Journal: Neuropharmacology20070401
Title: Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.
Journal: The Journal of biological chemistry20070323
Title: Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.
Journal: Journal of immunology (Baltimore, Md. : 1950)20070315
Title: Impact of long-term therapy with FTY720 or mycophenolate mofetil on cardiac conduction and rhythm in stable adult renal transplant patients.
Journal: Transplantation20070315
Title: Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
Journal: The Journal of biological chemistry20070309
Title: The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology20070301
Title: Oral-intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effects.
Journal: Biopharmaceutics & drug disposition20070301
Title: Tipping the gatekeeper: S1P regulation of endothelial barrier function.
Journal: Trends in immunology20070301
Title: FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.
Journal: Expert opinion on investigational drugs20070301
Title: Sphingosine-1-phosphate and FTY720 as anti-atherosclerotic lipid compounds.
Journal: European journal of clinical investigation20070301
Title: FTY720 application following isolated warm liver ischemia improves long-term survival and organ protection in a mouse model.
Journal: Transplantation proceedings20070301
Title: FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia; impact on long-term survival and T-lymphocyte tissue infiltration.
Journal: Transplantation proceedings20070301
Title: Chemokines and chemokine receptors in renal transplantation--from bench to bedside.
Journal: Acta physiologica Hungarica20070301
Title: FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury.
Journal: Journal of cellular and molecular medicine20070301
Title: FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950)20070215
Title: The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
Journal: Blood20070201
Title: Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.
Journal: Arteriosclerosis, thrombosis, and vascular biology20070201
Title: Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway.
Journal: International journal of oncology20070201
Title: Oral pharmacokinetic and pharmacodynamic effects of FTY720 in cats.
Journal: Journal of veterinary pharmacology and therapeutics20070201
Title: Is fingolimod an advancement in the treatment of multiple sclerosis? KAPPOS L, ANTEL J, COMI G. et al.: Oral fingolimod (FTY720) for relapsing multiple sclerosis. N. Engl. J. Med. (2006) 355:1124-1140.
Journal: Expert opinion on pharmacotherapy20070201
Title: Ethnic sensitivity study of fingolimod in white and Asian subjects.
Journal: International journal of clinical pharmacology and therapeutics20070201
Title: [Effect of mono and combination therapy with FTY720 and ICAM-1 mAb for mouse-to-rat cardiac xenotransplantation].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences20070201
Title: FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice.
Journal: Circulation20070130
Title: Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.
Journal: Bioorganic & medicinal chemistry letters20070115
Title: FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease.
Journal: European journal of immunology20070101
Title: Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipients.
Journal: International immunopharmacology20070101
Title: Multiple sclerosis: new insights and therapeutic progress.
Journal: The Lancet. Neurology20070101
Title: Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling.
Journal: The American journal of pathology20070101
Title: New immunosuppresor strategies in the treatment of murine lupus nephritis.
Journal: Lupus20070101
Title: FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.
Journal: Anticancer research20070101
Title: Long-term effect of FTY720 on lymphocyte count and islet allograft survival in mice.
Journal: Microsurgery20070101
Title: Oral disease-modifying treatments for multiple sclerosis: the story so far.
Journal: CNS drugs20070101
Title: Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart.
Journal: Journal of biochemical and molecular toxicology20070101
Title: Induction therapy in pediatric renal transplant recipients: an overview.
Journal: Paediatric drugs20070101
Title: Sphingosine-1-phosphate signaling and the skin.
Journal: American journal of clinical dermatology20070101
Title: FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology.
Journal: Perspectives in medicinal chemistry20070101
Title: Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation.
Journal: Transplantation20061227
Title: FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs.
Journal: International immunopharmacology20061220
Title: FTY720 in combination with cyclosporine--an analysis of skin allograft survival and renal function.
Journal: International immunopharmacology20061220
Title: Tacrolimus in combination with FTY720--an analysis of renal and blood parameters.
Journal: International immunopharmacology20061220
Title: FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20061201
Title: Regulation of donor T cells in the tolerant rats to graft-versus-host disease by FTY720 following small bowel transplantation.
Journal: Transplantation proceedings20061201
Title: Exposure-efficacy relationships of a fingolimod-everolimus regimen in kidney transplant patients at risk for delayed graft function.
Journal: Transplantation proceedings20061201
Title: Comparative quantification of sphingolipids and analogs in biological samples by high-performance liquid chromatography after chloroform extraction.
Journal: Analytical biochemistry20061115
Title: Measurement and stability of FTY720 in human whole blood by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20061107
Title: Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.
Journal: The Journal of clinical investigation20061101
Title: Effect of FTY720 in rat small bowel transplantation: apoptosis of crypt cells and lymphocytes in gut-associated lymphoid tissues.
Journal: Transplantation proceedings20061101
Title: The curtain is drawn for both natalizumab and fingolimod (FTY720): a new era of multiple sclerosis therapy has arrived.
Journal: Expert review of neurotherapeutics20061101
Title: Bioactive sphingolipids in the modulation of the inflammatory response.
Journal: Pharmacology & therapeutics20061001
Title: Inhibition of donor-derived T cells trafficking into target organs by FTY720 during acute graft-versus-host disease in small bowel transplantation.
Journal: Clinical and experimental immunology20061001
Title: The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice.
Journal: Oncology reports20061001
Title: Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration.
Journal: The New England journal of medicine20060914
Title: Oral fingolimod (FTY720) for relapsing multiple sclerosis.
Journal: The New England journal of medicine20060914
Title: Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.
Journal: Drug metabolism and disposition: the biological fate of chemicals20060901
Title: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.
Journal: American journal of physiology. Gastrointestinal and liver physiology20060801
Title: FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20060801
Title: Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.
Journal: Nature chemical biology20060801
Title: FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects.
Journal: Journal of clinical pharmacology20060801
Title: [Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics].
Journal: Seikagaku. The Journal of Japanese Biochemical Society20060801
Title: Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.
Journal: Bioorganic & medicinal chemistry letters20060715
Title: Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
Journal: Molecular pharmacology20060701
Title: Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice.
Journal: Biochemical and biophysical research communications20060623
Title: Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720.
Journal: Bioorganic & medicinal chemistry20060615
Title: Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.
Journal: American journal of physiology. Renal physiology20060601
Title: Pulmonary and vascular pharmacology of sphingosine 1-phosphate.
Journal: Current opinion in pharmacology20060601
Title: Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.
Journal: European journal of immunology20060601
Title: In vitro evaluation of the effect of a novel immunosuppressive agent, FTY720, on the function of feline neutrophils.
Journal: American journal of veterinary research20060401
Title: Evidence that FTY720 induces rat thymocyte apoptosis.
Journal: Transplant immunology20060401
Title: FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells.
Journal: Transplant immunology20060401
Title: FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia in C57/BL6 mice.
Journal: Transplantation proceedings20060401
Title: A photoreactive analogue of the immunosuppressant FTY720.
Journal: The Journal of organic chemistry20060303
Title: Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20060301
Title: FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase.
Journal: Cancer letters20060220
Title: Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
Journal: Blood20060215
Title: Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.
Journal: Journal of immunology (Baltimore, Md. : 1950)20060201
Title: Fingolimod (FTY720) in severe hepatic impairment: pharmacokinetics and relationship to markers of liver function.
Journal: Journal of clinical pharmacology20060201
Title: [Molecular action mechanisms of the therapeutic agents for kidney diseases: Immunosuppressants].
Journal: Nihon rinsho. Japanese journal of clinical medicine20060201
Title: Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus.
Journal: Cellular & molecular immunology20060201
Title: Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival.
Journal: Journal of immunology (Baltimore, Md. : 1950)20060115
Title: NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies.
Journal: Bioorganic & medicinal chemistry letters20060101
Title: The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
Journal: British journal of pharmacology20060101
Title: Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection.
Journal: Journal of immunology (Baltimore, Md. : 1950)20060101
Title: Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization.
Journal: Cancer research20060101
Title: The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology.
Journal: Archivum immunologiae et therapiae experimentalis20060101
Title: Immunotherapy for De Novo renal transplantation: what's in the pipeline?
Journal: Drugs20060101
Title: FTY720 (fingolimod) in renal transplantation.
Journal: Clinical transplantation20060101
Title: Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.
Journal: Clinical transplantation20060101
Title: Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Journal: Current pharmaceutical design20060101
Title: FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.
Journal: International journal of cancer20051220
Title: The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.
Journal: Journal of immunology (Baltimore, Md. : 1950)20051215
Title: FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors.
Journal: Pharmacology & therapeutics20051201
Title: Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.
Journal: European journal of immunology20051201
Title: Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes.
Journal: Journal of immunology (Baltimore, Md. : 1950)20051201
Title: FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20051201
Title: Multiple sclerosis poses tough drug development challenges.
Journal: Drug discovery today20051201
Title: Use of FTY 720 and ICAM-1 antisense oligonucleotides for attenuating chronic renal damage secondary to ischemia-reperfusion injury.
Journal: Transplantation proceedings20051201
Title: Effect of FTY720 in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Transplantation proceedings20051201
Title: FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.
Journal: Cellular & molecular immunology20051201
Title: Effect of FTY720 on chronic cyclosporine nephropathy in rats.
Journal: Transplantation20051115
Title: Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.
Journal: The Journal of biological chemistry20051104
Title: The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20051101
Title: FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship.
Journal: Journal of clinical pharmacology20051101
Title: FTY720 inhibits TH1-mediated allogeneic humoral immune response.
Journal: Transplantation proceedings20051101
Title: The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.
Journal: The Journal of biological chemistry20051007
Title: [Multiple sclerosis. A new oral immunomodulator].
Journal: Medizinische Monatsschrift fur Pharmazeuten20051001
Title: Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates.
Journal: Toxicology20050915
Title: Immunology. Dietary factors and immunological consequences.
Journal: Science (New York, N.Y.)20050909
Title: Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950)20050901
Title: Sphingosine-1-phosphate mediates migration of mature dendritic cells.
Journal: Journal of immunology (Baltimore, Md. : 1950)20050901
Title: Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma.
Journal: Molecular cancer therapeutics20050901
Title: The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.
Journal: Blood20050815
Title: FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Journal: Cancer research20050815
Title: Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
Journal: Journal of medicinal chemistry20050811
Title: Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement.
Journal: Journal of leukocyte biology20050801
Title: Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.
Journal: Bioorganic & medicinal chemistry letters20050801
Title: [Effects of sphingosine 1-phosphate on functions of T cell - review].
Journal: Zhongguo shi yan xue ye xue za zhi20050801
Title: Protection of mouse small bowel allografts by FTY720 and costimulation blockade.
Journal: Transplantation20050627
Title: FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation.
Journal: Transplantation20050615
Title: Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in experimental autoimmune encephalitis.
Journal: Journal of magnetic resonance imaging : JMRI20050601
Title: Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720.
Journal: Transplantation20050515
Title: Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas20050501
Title: Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.
Journal: Circulation research20050429
Title: A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis.
Journal: Regulatory peptides20050415
Title: FTY720 pharmacokinetics in mild to moderate hepatic impairment.
Journal: Journal of clinical pharmacology20050401
Title: FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration.
Journal: Pancreas20050401
Title: A novel immunomodulator, FTY720, prevents development of experimental autoimmune myasthenia gravis in C57BL/6 mice.
Journal: Biological & pharmaceutical bulletin20050401
Title: Sphingosine 1-phosphate analogs as receptor antagonists.
Journal: The Journal of biological chemistry20050318
Title: [Study of the effects of immunosuppressive agents on human islet cells in vitro].
Journal: Zhonghua yi xue za zhi20050316
Title: Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target.
Journal: Carcinogenesis20050301
Title: The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20050301
Title: On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approach.
Journal: Basic & clinical pharmacology & toxicology20050301
Title: Fingolimod. Mitsubishi Pharma/Novartis.
Journal: IDrugs : the investigational drugs journal20050301
Title: Preoperative administration of FTY720 prolonged renal allograft survival.
Journal: Transplant immunology20050301
Title: Novel mediators of FTY720 in human lymphocytes.
Journal: Transplantation20050227
Title: FTY720 in corneal concordant xenotransplantation.
Journal: Transplantation20050215
Title: The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells.
Journal: European journal of immunology20050201
Title: Effect of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice.
Journal: World journal of gastroenterology20050128
Title: KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.
Journal: Circulation20050118
Title: Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate.
Journal: Bioorganic & medicinal chemistry20050117
Title: A convenient synthesis of immunosuppressive agent FTY720 using the petasis reaction.
Journal: Chemical & pharmaceutical bulletin20050101
Title: FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20050101
Title: Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.
Journal: Annual review of immunology20050101
Title: [New immunodepressant drugs for the prevention and control of kidney transplant rejection].
Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia20050101
Title: Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate.
Journal: Transplantation proceedings20050101
Title: Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: II. Effect of FTY720 and FTY720-phosphate on host-versus-graft and graft-versus-host reaction in mice.
Journal: Transplantation proceedings20050101
Title: FTY720 inhibits tumor growth and angiogenesis.
Journal: Transplantation proceedings20050101
Title: Prolonged administration of FTY720 does not cause renal toxicity in mice.
Journal: Transplantation proceedings20050101
Title: Control of intestinal allograft rejection by FTY720 and costimulation blockade.
Journal: Transplantation proceedings20050101
Title: FTY720 prevents renal T-cell infiltration after ischemia/reperfusion injury.
Journal: Transplantation proceedings20050101
Title: The effect of a novel immunosuppressant, FTY720, in mice without secondary lymphoid organs.
Journal: Surgery today20050101
Title: FTY720: mechanism of action and potential benefit in organ transplantation.
Journal: Yonsei medical journal20041231
Title: A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
Journal: Journal of medicinal chemistry20041230
Title: FTY720 suppresses humoral immunity by inhibiting germinal center reaction.
Journal: Blood20041215
Title: Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
Journal: The Journal of biological chemistry20041210
Title: FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation.
Journal: Carcinogenesis20041201
Title: Overview of FTY720 clinical pharmacokinetics and pharmacology.
Journal: Therapeutic drug monitoring20041201
Title: Novel immunosuppressants.
Journal: Pediatric transplantation20041201
Title: Rejection following donor or recipient preoperative treatment with FTY720 in rat small bowel transplantation.
Journal: Transplant immunology20041101
Title: Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century.
Journal: Current opinion in investigational drugs (London, England : 2000)20041101
Title: A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments.
Journal: Transplant international : official journal of the European Society for Organ Transplantation20041101
Title: Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells.
Journal: Experimental & molecular medicine20041031
Title: Modulation of adaptive immune responses by sphingosine-1-phosphate.
Journal: Seminars in cell & developmental biology20041001
Title: Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis.
Journal: Kidney international20041001
Title: Effects of FTY720 on rat lymphoid organs.
Journal: Transplantation proceedings20041001
Title: [Immunossupresive drugs in renal transplantation].
Journal: Polskie Archiwum Medycyny Wewnetrznej20041001
Title: Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.
Journal: Bioorganic & medicinal chemistry20040915
Title: Attenuation of small-for-size liver graft injury by FTY720: significance of cell-survival Akt signaling pathway.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20040901
Title: Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration.
Journal: Kidney international20040901
Title: A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice.
Journal: Biological & pharmaceutical bulletin20040901
Title: Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.
Journal: The Journal of biological chemistry20040827
Title: The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20040801
Title: Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.
Journal: Journal of neuroimmunology20040801
Title: FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments.
Journal: Journal of immunology (Baltimore, Md. : 1950)20040715
Title: Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.
Journal: Nature immunology20040701
Title: FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20040701
Title: FTY720--the first compound of a new promising class of immunosuppressive drugs.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20040701
Title: FTY720 prolongs clear corneal allograft survival with a differential effect on different lymphocyte populations.
Journal: The British journal of ophthalmology20040701
Title: Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging.
Journal: Journal of magnetic resonance imaging : JMRI20040701
Title: Should we B-leavin' now?
Journal: Nature immunology20040701
Title: FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation.
Journal: Transplantation20040627
Title: Effect of FTY720 on rat small bowel transplantation.
Journal: Transplantation20040627
Title: Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Journal: Bioorganic & medicinal chemistry letters20040621
Title: The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells.
Journal: Blood20040615
Title: Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.
Journal: American journal of respiratory and critical care medicine20040601
Title: FTY720 prevents anti-CD4 mAb-induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20040601
Title: Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy.
Journal: Biochimica et biophysica acta20040601
Title: ['Vegetable wasps and plant worms' and G-protein-coupled receptors].
Journal: Journal of UOEH20040601
Title: Future immunosuppressive agents in solid-organ transplantation.
Journal: Progress in transplantation (Aliso Viejo, Calif.)20040601
Title: Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720.
Journal: The Journal of organic chemistry20040528
Title: FTY: not just a homely drug.
Journal: Transplantation20040515
Title: FTY720 mediates apoptosis-independent lymphopenia in human renal allograft recipients: different effects on CD62L+ and CCR5+ T lymphocytes.
Journal: Transplantation20040515
Title: Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
Journal: The Journal of pharmacology and experimental therapeutics20040501
Title: Immunoregulatory lysophospholipids: new stars in the mast cell constellation.
Journal: Current allergy and asthma reports20040501
Title: Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects.
Journal: British journal of clinical pharmacology20040501
Title: Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects.
Journal: Journal of clinical pharmacology20040501
Title: FTY720 impairs necrosis development after ischemia-reperfusion injury.
Journal: Transplantation proceedings20040501
Title: FTY720 treatment prolongs skin graft survival in a completely incompatible strain combination.
Journal: Transplantation proceedings20040501
Title: Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis.
Journal: Inflammatory bowel diseases20040501
Title: Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.
Journal: The Journal of biological chemistry20040402
Title: Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720.
Journal: Transplantation20040327
Title: The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20040301
Title: FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association20040301
Title: FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury.
Journal: Kidney international20040301
Title: FTY720: from bench to bedside.
Journal: Transplantation proceedings20040301
Title: FTY720: early clinical experience.
Journal: Transplantation proceedings20040301
Title: FTY720 immunomodulation: optimism for improved transplant regimens.
Journal: Transplantation proceedings20040301
Title: The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat.
Journal: Pediatric diabetes20040301
Title: Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
Journal: Nature20040122
Title: CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20040101
Title: Pharmacologic immunosuppression.
Journal: Frontiers in bioscience : a journal and virtual library20040101
Title: FTY720 and cyclosporine: evaluation for a pharmacokinetic interaction.
Journal: The Annals of pharmacotherapy20040101
Title: Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells.
Journal: Prostaglandins & other lipid mediators20040101
Title: Role of extracelluar regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban20040101
Title: Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.
Journal: Journal of immunology (Baltimore, Md. : 1950)20031201
Title: Current immunosuppressive agents: efficacy, side effects, and utilization.
Journal: Pediatric clinics of North America20031201
Title: Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.
Journal: The Journal of biological chemistry20031128
Title: Significant prolongation of orthotopic corneal-graft survival in FTY720-treated mice.
Journal: Transplantation20031127
Title: Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
Journal: The Journal of biological chemistry20031121
Title: The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
Journal: FEBS letters20031106
Title: FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model.
Journal: Transplantation20031027
Title: Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study.
Journal: Transplantation20031015
Title: Egress: a receptor-regulated step in lymphocyte trafficking.
Journal: Immunological reviews20031001
Title: Pharmacodynamics of FTY720, the first member of a new class of immune-modulating therapeutics in transplantation medicine.
Journal: International journal of clinical pharmacology and therapeutics20031001
Title: [Study the mechanisms and inducing transplantation immune tolerance of FTY720].
Journal: Zhonghua wai ke za zhi [Chinese journal of surgery]20031001
Title: FTY720, a new immunosuppressant, as rescue therapy in mouse cardiac transplantation.
Journal: Acta pharmacologica Sinica20030901
Title: Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm.
Journal: Current opinion in chemical biology20030801
Title: Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae.
Journal: The Journal of biological chemistry20030718
Title: Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20030701
Title: FTY720: A new kid on the block for transplant immunosuppression.
Journal: Expert opinion on biological therapy20030701
Title: Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment.
Journal: The Journal of urology20030601
Title: The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance.
Journal: Transplant international : official journal of the European Society for Organ Transplantation20030601
Title: Prevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides.
Journal: Transplantation proceedings20030601
Title: FTY720 reduces T-cell recruitment into murine intestinal allograft and prevents activation of graft-infiltrating cells.
Journal: Transplantation20030515
Title: Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats.
Journal: Transplantation20030427
Title: FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A.
Journal: Transplantation20030415
Title: Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950)20030401
Title: Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment.
Journal: The Journal of pharmacology and experimental therapeutics20030401
Title: A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells.
Journal: British journal of pharmacology20030401
Title: The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice.
Journal: Clinical immunology (Orlando, Fla.)20030401
Title: FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.
Journal: The Journal of clinical investigation20030301
Title: Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.
Journal: The Journal of clinical investigation20030301
Title: Elimination of cell-cycle regulators during caspase-3-dependent apoptosis caused by an immunosuppressant, FTY720.
Journal: Bioscience, biotechnology, and biochemistry20030301
Title: [Effects of three different immunosuppressive drugs on SD rat islet cell viability].
Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA20030201
Title: CTLA4Ig-gene transfection with FTY720 administration markedly inhibits the obliterative airway disease in heterotopically transplanted rat tracheas.
Journal: Transplantation proceedings20030201
Title: Pretreatment with FTY720 alone induced long-term survival of mouse heart allograft.
Journal: Transplantation proceedings20030201
Title: Linking Chinese medicine and G-protein-coupled receptors.
Journal: Trends in pharmacological sciences20030101
Title: Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.
Journal: Anticancer research20030101
Title: Renal transplantation: basic concepts and evolution of therapy.
Journal: Journal of clinical apheresis20030101
Title: New paradigms in immunosuppression.
Journal: CANNT journal = Journal ACITN20030101
Title: Different mechanisms for membrane and nuclear damages in apoptosis induced by an immunosuppressant, FTY720.
Journal: Molecules and cells20021231
Title: Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice.
Journal: Transplantation20021227
Title: T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2.
Journal: British journal of pharmacology20021201
Title: Efficacy of mycophenolate sodium as monotherapy and in combination with FTY720 in a DA-to-Lewis-rat heart-transplantation model.
Journal: Transplantation20021127
Title: Sirolimus and FTY720: new approaches to transplant immunosuppression.
Journal: Transplantation proceedings20021101
Title: Effects of mycophenolate sodium with or without FTY720 in a DA-to-Lewis rat heart transplantation model.
Journal: Transplantation proceedings20021101
Title: Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD.
Journal: Transplantation20021015
Title: Transplantation.
Journal: Current opinion in immunology20021001
Title: FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.
Journal: Current opinion in immunology20021001
Title: FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20021001
Title: Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat.
Journal: Transplantation20020915
Title: FTY720 alters the composition of T-lymphocyte subpopulations in the peripheral blood compartment of renal transplant patients.
Journal: Transplantation proceedings20020901
Title: Combined therapy of CTLA4Ig-gene transfection with FTY720 administration in rat lung allografts.
Journal: Transplantation proceedings20020801
Title: FTY720: a novel approach to the treatment of hepatic ischemia-reperfusion injury.
Journal: Transplantation proceedings20020801
Title: A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine.
Journal: Cancer letters20020726
Title: The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Journal: The Journal of biological chemistry20020614
Title: Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation20020601
Title: Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720.
Journal: Transplantation20020515
Title: Pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (FTY720) in cynomolgus monkeys after single oral and intravenous doses.
Journal: The Journal of pharmacology and experimental therapeutics20020501
Title: Combined use of FTY720 and cyclosporine A prevents chronic allograft vasculopathy.
Journal: Transplantation proceedings20020501
Title: Donor pretreatment with FTY720 increases graft lymphocytes but does not affect graft survival following rat small bowel transplantation.
Journal: Transplantation proceedings20020501
Title: Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Journal: Science (New York, N.Y.)20020412
Title: First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients.
Journal: Journal of the American Society of Nephrology : JASN20020401
Title: Effects of FTY720 in MRL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus.
Journal: The Journal of rheumatology20020401
Title: Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis.
Journal: International journal of cancer20020310
Title: Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells).
Journal: The Journal of pharmacology and experimental therapeutics20020301
Title: Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.
Journal: Cancer research20020301
Title: L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance.
Journal: Journal of immunology (Baltimore, Md. : 1950)20020215
Title: Update on pharmacokinetic/pharmacodynamic studies with FTY720 and sirolimus.
Journal: Therapeutic drug monitoring20020201
Title: What role for FTY720, a novel immunosuppressive agent, in canine nonmyeloablative hematopoietic stem cell transplantation?
Journal: Transplantation20020127
Title: Activation of caspases and mitochondria in FTY720-mediated apoptosis in human T cell line Jurkat.
Journal: International immunopharmacology20011001
Title: FTY720: altered lymphocyte traffic results in allograft protection.
Journal: Transplantation20010915
Title: [mTOR and FTY 720 inhibitors].
Journal: Presse medicale (Paris, France : 1983)20010901
Title: [What is new on transplantation in 2001?].
Journal: Presse medicale (Paris, France : 1983)20010901
Title: Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.
Journal: FEBS letters20010817
Title: Coexpression of CD4 and CD8alpha on rat T-cells in whole blood: a sensitive marker for monitoring T-cell immunosuppressive drugs.
Journal: Journal of immunological methods20010801
Title: Combined FTY720/cyclosporine treatment promotes graft survival and lowers the peripheral lymphocyte count in a murine cardiac allotransplantation model.
Journal: Transplantation20010715
Title: A high-capacity quantitative mouse model of drug-mediated immunosuppression based on rejection of an allogeneic subcutaneous tumor.
Journal: The Journal of pharmacology and experimental therapeutics20010601
Title: Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720.
Journal: Japanese journal of cancer research : Gann20010601
Title: Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis.
Journal: Journal of the American College of Cardiology20010501
Title: Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count.
Journal: Transplantation proceedings20010501
Title: FTY-720 is efficacious in monkey kidney transplantation.
Journal: Transplantation proceedings20010501
Title: Long-term graft acceptance in rat heart transplantation by CTLA4Ig gene transfection combined with FTY720 treatment.
Journal: World journal of surgery20010401
Title: New immunosuppressive drugs: an update.
Journal: Current opinion in urology20010301
Title: Treatment of transplant rejection: are the traditional immunosuppressants good enough?
Journal: Current opinion in investigational drugs (London, England : 2000)20010301
Title: FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells.
Journal: Biochemical and biophysical research communications20010223
Title: Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720.
Journal: Clinical and experimental immunology20010201
Title: Combined FTY720/cyclosporine A treatment promotes graft survival and lowers the peripheral lymphocyte count in DA to lewis heart and skin transplantation models.
Journal: Transplant immunology20010201
Title: Immunosuppressive drugs in paediatric liver transplantation.
Journal: Paediatric drugs20010101
Title: FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression.
Journal: Transplantation proceedings20010101
Title: FTY720 prevents chronic rejection of rat heterotopic cardiac allografts.
Journal: Transplantation proceedings20010101
Title: FTY720, a novel immunosuppressive agent with insulinotropic activity, prolongs graft survival in a mouse islet transplantation model.
Journal: Transplantation proceedings20010101
Title: FTY 720 prevents ischemic reperfusion damage in rat kidneys.
Journal: Transplantation proceedings20010101
Title: FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines.
Journal: Transplantation proceedings20010101
Title: FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects.
Journal: Transplantation proceedings20010101
Title: FTY720: a new dimension in transplantation.
Journal: Transplantation proceedings20010101
Title: T-cell apoptosis triggered by FTY720 via mitochondrial pathway.
Journal: Transplantation proceedings20010101
Title: Rolin J, et al. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010, 59(4), 575-586.
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