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1626387-80-1,MFCD29058564
Catalog No.:AA001T74

1626387-80-1 | (2R)-2,4-dimethyl-1-piperazinecarboxylic acid, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$10.00   $7.00
- +
10mg
98%
in stock  
$12.00   $8.00
- +
50mg
98%
in stock  
$20.00   $14.00
- +
100mg
98%
in stock  
$24.00   $17.00
- +
250mg
98%
in stock  
$46.00   $32.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001T74
Chemical Name:
(2R)-2,4-dimethyl-1-piperazinecarboxylic acid, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester
CAS Number:
1626387-80-1
Molecular Formula:
C22H23ClFN5O3
Molecular Weight:
459.9011
MDL Number:
MFCD29058564
SMILES:
COc1cc2ncnc(c2cc1OC(=O)N1CCN(C[C@H]1C)C)Nc1cccc(c1F)Cl
Properties
Computed Properties
 
Complexity:
649  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2014/135876,2014,A1Locationinpatent:Page/Pagecolumn43-45

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2014/255428,2014,A1Locationinpatent:Paragraph0253-0254

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2014/135876,2014,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2014/255428,2014,A1

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2014/135876,2014,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2014/255428,2014,A1

230955-75-6   
4-(3-chloro-2-fluorophenyl)amino-7-methoxyquinazolin-6-yl(2R)-2,4-dimethylpiperazine-1-carboxylate 

[1]Patent:WO2014/135876,2014,A1

[2]Patent:US2014/255428,2014,A1

[3]JournalofMedicinalChemistry,2015,vol.58,p.8200-8215

[4]Patent:CN109438423,2019,A

740081-22-5   
4-(3-chloro-2-fluorophenyl)amino-7-methoxyquinazolin-6-yl(2R)-2,4-dimethylpiperazine-1-carboxylate 

[1]Patent:WO2014/135876,2014,A1

[2]Patent:US2014/255428,2014,A1

[3]Patent:CN109438423,2019,A

Literature

Title: Zeng Q, et al. Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. J Med Chem. 2015 Oct 22;58(20):8200-15.

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SDS
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Tags:1626387-80-1 Molecular Formula|1626387-80-1 MDL|1626387-80-1 SMILES|1626387-80-1 (2R)-2,4-dimethyl-1-piperazinecarboxylic acid, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester
Catalog No.: AA001T74
1626387-80-1,MFCD29058564
1626387-80-1 | (2R)-2,4-dimethyl-1-piperazinecarboxylic acid, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester
Pack Size： 5mg
Purity： 98%
in stock
$10.00 $7.00
Pack Size： 10mg
Purity： 98%
in stock
$12.00 $8.00
Pack Size： 50mg
Purity： 98%
in stock
$20.00 $14.00
Pack Size： 100mg
Purity： 98%
in stock
$24.00 $17.00
Pack Size： 250mg
Purity： 98%
in stock
$46.00 $32.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001T74
Chemical Name: (2R)-2,4-dimethyl-1-piperazinecarboxylic acid, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester
CAS Number: 1626387-80-1
Molecular Formula: C22H23ClFN5O3
Molecular Weight: 459.9011
MDL Number: MFCD29058564
SMILES: COc1cc2ncnc(c2cc1OC(=O)N1CCN(C[C@H]1C)C)Nc1cccc(c1F)Cl
Properties
Complexity: 649  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 32  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.1  
Downstream Synthesis Route
1626387-80-1    1626387-81-2 

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2014/135876,2014,A1Locationinpatent:Page/Pagecolumn43-45

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2014/255428,2014,A1Locationinpatent:Paragraph0253-0254

179688-52-9    1626387-80-1 

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2014/135876,2014,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2014/255428,2014,A1

179688-53-0    1626387-80-1 

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2014/135876,2014,A1

[2]CurrentPatentAssignee:ASTRAZENECAPLC-US2014/255428,2014,A1

230955-75-6   
4-(3-chloro-2-fluorophenyl)amino-7-methoxyquinazolin-6-yl(2R)-2,4-dimethylpiperazine-1-carboxylate 

[1]Patent:WO2014/135876,2014,A1

[2]Patent:US2014/255428,2014,A1

[3]JournalofMedicinalChemistry,2015,vol.58,p.8200-8215

[4]Patent:CN109438423,2019,A

740081-22-5   
4-(3-chloro-2-fluorophenyl)amino-7-methoxyquinazolin-6-yl(2R)-2,4-dimethylpiperazine-1-carboxylate 

[1]Patent:WO2014/135876,2014,A1

[2]Patent:US2014/255428,2014,A1

[3]Patent:CN109438423,2019,A

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Historical Records
28992-50-9
28992-50-9
951932-21-1
951932-21-1
838386-62-2
838386-62-2
861369-81-5
861369-81-5
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