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1627503-67-6,MFCD28168043
Catalog No.:AA001TBA

1627503-67-6 | LDN-214117

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$156.00   $109.00
- +
10mg
≥98%
in stock  
$263.00   $184.00
- +
25mg
in stock  
$495.00   $347.00
- +
100mg
in stock  
$1,120.00   $784.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001TBA
Chemical Name:
LDN-214117
CAS Number:
1627503-67-6
Molecular Formula:
C25H29N3O3
Molecular Weight:
419.5161
MDL Number:
MFCD28168043
SMILES:
COc1cc(cc(c1OC)OC)c1cc(cnc1C)c1ccc(cc1)N1CCNCC1
Properties
Computed Properties
 
Complexity:
522  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.9  

Literature

Title: Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.

Journal: Journal of medicinal chemistry 20141009

Title: ACVR1 (587T>C) mutation in a variant form of fibrodysplasia ossificans progressiva: second report.

Journal: American journal of medical genetics. Part A 20140101

Title: Fibrodysplasia ossificans progressiva: clinical and genetic aspects.

Journal: Orphanet journal of rare diseases 20110101

Title: Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1.

Journal: Human mutation 20090301

Title: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.

Journal: Nature genetics 20060501

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SDS
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 1431957-72-0

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1251595-60-4
Tags:1627503-67-6 Molecular Formula|1627503-67-6 MDL|1627503-67-6 SMILES|1627503-67-6 LDN-214117
Catalog No.: AA001TBA
1627503-67-6,MFCD28168043
1627503-67-6 | LDN-214117
Pack Size： 1mg
Purity： ≥98%
in stock
$46.00 $32.00
Pack Size： 5mg
Purity： ≥98%
in stock
$156.00 $109.00
Pack Size： 10mg
Purity： ≥98%
in stock
$263.00 $184.00
Pack Size： 25mg
Purity：
in stock
$495.00 $347.00
Pack Size： 100mg
Purity：
in stock
$1,120.00 $784.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001TBA
Chemical Name: LDN-214117
CAS Number: 1627503-67-6
Molecular Formula: C25H29N3O3
Molecular Weight: 419.5161
MDL Number: MFCD28168043
SMILES: COc1cc(cc(c1OC)OC)c1cc(cnc1C)c1ccc(cc1)N1CCNCC1
Properties
Complexity: 522  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.9  
Literature fold

Title: Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.

Journal: Journal of medicinal chemistry20141009

Title: ACVR1 (587T>C) mutation in a variant form of fibrodysplasia ossificans progressiva: second report.

Journal: American journal of medical genetics. Part A20140101

Title: Fibrodysplasia ossificans progressiva: clinical and genetic aspects.

Journal: Orphanet journal of rare diseases20110101

Title: Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1.

Journal: Human mutation20090301

Title: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.

Journal: Nature genetics20060501

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1251595-60-4
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