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Home Other Building Blocks 1628317-18-9
1628317-18-9,MFCD28506301
Catalog No.:AA00AR3Z

1628317-18-9 | MI-463

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$21.00   $15.00
- +
5mg
97%
in stock  
$52.00   $36.00
- +
10mg
97%
in stock  
$76.00   $54.00
- +
25mg
97%
in stock  
$131.00   $92.00
- +
50mg
97%
in stock  
$212.00   $149.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AR3Z
Chemical Name:
MI-463
CAS Number:
1628317-18-9
Molecular Formula:
C24H23F3N6S
Molecular Weight:
484.5398
MDL Number:
MFCD28506301
SMILES:
N#Cc1[nH]c2c(c1)c(C)c(cc2)CN1CCC(CC1)Nc1ncnc2c1cc(s2)CC(F)(F)F
Properties
Computed Properties
 
Complexity:
751  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
5.9  

Downstream Synthesis Route

[1]Borkin,Dmitry;Pollock,Jonathan;Kempinska,Katarzyna;Purohit,Trupta;Li,Xiaoqin;Wen,Bo;Zhao,Ting;Miao,Hongzhi;Shukla,Shirish;He,Miao;Sun,Duxin;Cierpicki,Tomasz;Grembecka,Jolanta[JournalofMedicinalChemistry,2016,vol.59,#3,p.892-913]

[1]Borkin,Dmitry;Pollock,Jonathan;Kempinska,Katarzyna;Purohit,Trupta;Li,Xiaoqin;Wen,Bo;Zhao,Ting;Miao,Hongzhi;Shukla,Shirish;He,Miao;Sun,Duxin;Cierpicki,Tomasz;Grembecka,Jolanta[JournalofMedicinalChemistry,2016,vol.59,#3,p.892-913]

[1]Borkin,Dmitry;Pollock,Jonathan;Kempinska,Katarzyna;Purohit,Trupta;Li,Xiaoqin;Wen,Bo;Zhao,Ting;Miao,Hongzhi;Shukla,Shirish;He,Miao;Sun,Duxin;Cierpicki,Tomasz;Grembecka,Jolanta[JournalofMedicinalChemistry,2016,vol.59,#3,p.892-913]

83647-40-9   
4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno2,3-dpyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile 

[1]JournalofMedicinalChemistry,2016,vol.59,p.892-913

[1]Borkin,Dmitry;Pollock,Jonathan;Kempinska,Katarzyna;Purohit,Trupta;Li,Xiaoqin;Wen,Bo;Zhao,Ting;Miao,Hongzhi;Shukla,Shirish;He,Miao;Sun,Duxin;Cierpicki,Tomasz;Grembecka,Jolanta[JournalofMedicinalChemistry,2016,vol.59,#3,p.892-913]

Literature

Title: Borkin D, et al. Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell. 2015 Apr 13;27(4):589-602.

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SDS
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