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1631137-51-3,MFCD31630810
Catalog No.:AA01EO6B

1631137-51-3 | Protein degrader 1 TFA

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
99%
1 week  
$125.00   $88.00
- +
100mg
99%
1 week  
$213.00   $149.00
- +
250mg
99%
1 week  
$358.00   $251.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EO6B
Chemical Name:
Protein degrader 1 TFA
CAS Number:
1631137-51-3
Molecular Formula:
C24H31F3N4O5S
Molecular Weight:
544.5869
MDL Number:
MFCD31630810
SMILES:
OC(=O)C(F)(F)F.O[C@@H]1C[C@H](N(C1)C(=O)[C@H](C(C)(C)C)N)C(=O)NCc1ccc(cc1)c1scnc1C
Properties

Downstream Synthesis Route
1448189-98-7    76-05-1   
(2S,4R)-1-((S)-3,3-dimethyl-2-((2,2,2-trifluoroacetyl)-l4-azaneyl)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 

[1]Galdeano,Carles;Gadd,MorganS.;Soares,Pedro;Scaffidi,Salvatore;VanMolle,Inge;Birced,Ipek;Hewitt,Sarah;Dias,DavidM.;Ciulli,Alessio[JournalofMedicinalChemistry,2014,vol.57,#20,p.8657-8663]

[2]CurrentPatentAssignee:UNIVERSITYOFDUNDEE-WO2016/146985,2016,A1Locationinpatent:Page/Pagecolumn80

[3]Soares,Pedro;Gadd,MorganS.;Frost,Julianty;Galdeano,Carles;Ellis,Lucy;Epemolu,Ola;Rocha,Sonia;Read,KevinD.;Ciulli,Alessio[JournalofMedicinalChemistry,2018,vol.61,#2,p.599-618]

122957-57-7   
(2S,4R)-1-((S)-3,3-dimethyl-2-((2,2,2-trifluoroacetyl)-l4-azaneyl)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 

[1]JournalofMedicinalChemistry,2014,vol.57,p.8657-8663

[2]Patent:WO2016/146985,2016,A1

[1]Galdeano,Carles;Gadd,MorganS.;Soares,Pedro;Scaffidi,Salvatore;VanMolle,Inge;Birced,Ipek;Hewitt,Sarah;Dias,DavidM.;Ciulli,Alessio[JournalofMedicinalChemistry,2014,vol.57,#20,p.8657-8663]

[2]CurrentPatentAssignee:UNIVERSITYOFDUNDEE-WO2016/146985,2016,A1

1448189-30-7   
(2S,4R)-1-((S)-3,3-dimethyl-2-((2,2,2-trifluoroacetyl)-l4-azaneyl)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 

[1]JournalofMedicinalChemistry,2014,vol.57,p.8657-8663

[2]Patent:WO2016/146985,2016,A1

[1]Galdeano,Carles;Gadd,MorganS.;Soares,Pedro;Scaffidi,Salvatore;VanMolle,Inge;Birced,Ipek;Hewitt,Sarah;Dias,DavidM.;Ciulli,Alessio[JournalofMedicinalChemistry,2014,vol.57,#20,p.8657-8663]

[2]CurrentPatentAssignee:UNIVERSITYOFDUNDEE-WO2016/146985,2016,A1

Literature

Title: Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

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Tags:1631137-51-3 Molecular Formula|1631137-51-3 MDL|1631137-51-3 SMILES|1631137-51-3 Protein degrader 1 TFA
Catalog No.: AA01EO6B
1631137-51-3,MFCD31630810
1631137-51-3 | Protein degrader 1 TFA
Pack Size： 50mg
Purity： 99%
1 week
$125.00 $88.00
Pack Size： 100mg
Purity： 99%
1 week
$213.00 $149.00
Pack Size： 250mg
Purity： 99%
1 week
$358.00 $251.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA01EO6B
Chemical Name: Protein degrader 1 TFA
CAS Number: 1631137-51-3
Molecular Formula: C24H31F3N4O5S
Molecular Weight: 544.5869
MDL Number: MFCD31630810
SMILES: OC(=O)C(F)(F)F.O[C@@H]1C[C@H](N(C1)C(=O)[C@H](C(C)(C)C)N)C(=O)NCc1ccc(cc1)c1scnc1C
Properties
Downstream Synthesis Route
1448189-98-7    76-05-1   
(2S,4R)-1-((S)-3,3-dimethyl-2-((2,2,2-trifluoroacetyl)-l4-azaneyl)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 

[1]Galdeano,Carles;Gadd,MorganS.;Soares,Pedro;Scaffidi,Salvatore;VanMolle,Inge;Birced,Ipek;Hewitt,Sarah;Dias,DavidM.;Ciulli,Alessio[JournalofMedicinalChemistry,2014,vol.57,#20,p.8657-8663]

[2]CurrentPatentAssignee:UNIVERSITYOFDUNDEE-WO2016/146985,2016,A1Locationinpatent:Page/Pagecolumn80

[3]Soares,Pedro;Gadd,MorganS.;Frost,Julianty;Galdeano,Carles;Ellis,Lucy;Epemolu,Ola;Rocha,Sonia;Read,KevinD.;Ciulli,Alessio[JournalofMedicinalChemistry,2018,vol.61,#2,p.599-618]

122957-57-7   
(2S,4R)-1-((S)-3,3-dimethyl-2-((2,2,2-trifluoroacetyl)-l4-azaneyl)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 

[1]JournalofMedicinalChemistry,2014,vol.57,p.8657-8663

[2]Patent:WO2016/146985,2016,A1

623-00-7    1631137-51-3 

[1]Galdeano,Carles;Gadd,MorganS.;Soares,Pedro;Scaffidi,Salvatore;VanMolle,Inge;Birced,Ipek;Hewitt,Sarah;Dias,DavidM.;Ciulli,Alessio[JournalofMedicinalChemistry,2014,vol.57,#20,p.8657-8663]

[2]CurrentPatentAssignee:UNIVERSITYOFDUNDEE-WO2016/146985,2016,A1

1448189-30-7   
(2S,4R)-1-((S)-3,3-dimethyl-2-((2,2,2-trifluoroacetyl)-l4-azaneyl)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 

[1]JournalofMedicinalChemistry,2014,vol.57,p.8657-8663

[2]Patent:WO2016/146985,2016,A1

1631137-40-0    1631137-51-3 

[1]Galdeano,Carles;Gadd,MorganS.;Soares,Pedro;Scaffidi,Salvatore;VanMolle,Inge;Birced,Ipek;Hewitt,Sarah;Dias,DavidM.;Ciulli,Alessio[JournalofMedicinalChemistry,2014,vol.57,#20,p.8657-8663]

[2]CurrentPatentAssignee:UNIVERSITYOFDUNDEE-WO2016/146985,2016,A1

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