163521-12-8,MFCD09838919
Catalog No.:AA001U49

163521-12-8 | Vilazodone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98% by HPLC
in stock  
$109.00   $76.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001U49
Chemical Name:
Vilazodone
CAS Number:
163521-12-8
Molecular Formula:
C26H27N5O2
Molecular Weight:
441.5249
MDL Number:
MFCD09838919
SMILES:
N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2
Properties
Properties
 
BP:
745.1°C at 760 mmHg  
Form:
Solid  
MP:
203-205 °C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
729  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4  

Literature

Title: A review of current evidence for vilazodone in major depressive disorder.

Journal: International journal of psychiatry in clinical practice 20130801

Title: Evidence for the use of vilazodone in the treatment of major depressive disorder.

Journal: Expert opinion on pharmacotherapy 20121001

Title: Vilazodone for the treatment of major depressive disorder.

Journal: Pharmacotherapy 20121001

Title: Vilazodone's comparative merits yet to be demonstrated.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120915

Title: Vilazodone: a novel antidepressant.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120915

Title: Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.

Journal: European journal of medicinal chemistry 20120701

Title: Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

Journal: International journal of clinical practice 20120401

Title: New drugs 2012 part I.

Journal: Nursing 20120301

Title: Emerging drugs for major depressive disorder.

Journal: Expert opinion on emerging drugs 20120301

Title: The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder.

Journal: Current medical research and opinion 20120101

Title: Clinically significant drug interactions with newer antidepressants.

Journal: CNS drugs 20120101

Title: Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder.

Journal: P & T : a peer-reviewed journal for formulary management 20120101

Title: Translatability scoring in drug development: eight case studies.

Journal: Journal of translational medicine 20120101

Title: Selective serotonin reuptake inhibitors (SSRIs): therapeutic drug monitoring and pharmacological interactions.

Journal: Current medicinal chemistry 20120101

Title: Clinical utility of vilazodone for the treatment of adults with major depressive disorder and theoretical implications for future clinical use.

Journal: Neuropsychiatric disease and treatment 20120101

Title: Pharmacological management of binge eating disorder: current and emerging treatment options.

Journal: Therapeutics and clinical risk management 20120101

Title: A 1-year, open-label study assessing the safety and tolerability of vilazodone in patients with major depressive disorder.

Journal: Journal of clinical psychopharmacology 20111001

Title: Vilazodone: clinical basis for the US Food and Drug Administration's approval of a new antidepressant.

Journal: The Journal of clinical psychiatry 20110901

Title: A new antidepressant.

Journal: Behavioral healthcare 20110901

Title: Vilazodone (Viibryd)--a new antidepressant.

Journal: The Medical letter on drugs and therapeutics 20110711

Title: Vilazodone for the treatment of depression.

Journal: The Annals of pharmacotherapy 20110701

Title: Vilazodone: in major depressive disorder.

Journal: CNS drugs 20110701

Title: Vilazodone: a new treatment option for major depressive disorder.

Journal: Drugs of today (Barcelona, Spain : 1998) 20110701

Title: A randomized, double-blind, placebo-controlled, 8-week study of vilazodone, a serotonergic agent for the treatment of major depressive disorder.

Journal: The Journal of clinical psychiatry 20110401

Title: Vilazodone: another novel atypical antidepressant drug.

Journal: Journal of psychosocial nursing and mental health services 20110301

Title: Vilazodone approved for major depression.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110301

Title: Predicting impaired extinction of traumatic memory and elevated startle.

Journal: PloS one 20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Vilazodone hydrochloride, linagliptin, and alcaftadine.

Journal: Journal of the American Pharmacists Association : JAPhA 20110101

Title: Getting the balance right: Established and emerging therapies for major depressive disorders.

Journal: Neuropsychiatric disease and treatment 20100101

Title: Vilazodone, a novel dual-acting serotonergic antidepressant for managing major depression.

Journal: Expert opinion on investigational drugs 20091101

Title: Evidence for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled trial.

Journal: The Journal of clinical psychiatry 20090301

Title: Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders.

Journal: CNS neuroscience & therapeutics 20090101

Title: Drug evaluation: Vilazodone--a combined SSRI and 5-HT1A partial agonist for the treatment of depression.

Journal: IDrugs : the investigational drugs journal 20070301

Title: Effect of vilazodone on 5-HT efflux and re-uptake in the guinea-pig dorsal raphe nucleus.

Journal: European journal of pharmacology 20050704

Title: Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

Journal: European journal of pharmacology 20050307

Title: Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats.

Journal: European journal of pharmacology 20041103

Title: Dual 5-HT1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity.

Journal: Bioorganic & medicinal chemistry 20040915

Title: Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.

Journal: Journal of medicinal chemistry 20040909

Title: A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone.

Journal: Bioorganic & medicinal chemistry letters 20040517

Title: Phase I and II enzyme characterization of two sources of HepG2 cell lines.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040301

Title: Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist.

Journal: The Journal of pharmacology and experimental therapeutics 20020901

Title: Distinct temporal pattern of the effects of the combined serotonin-reuptake inhibitor and 5-HT1A agonist EMD 68843 on the sleep EEG in healthy men.

Journal: Psychopharmacology 20010501

Title: Systemic EMD 68843 injections reduce anxiety in the shock-probe, but not the plus-maze test.

Journal: European journal of pharmacology 20010302

Title: Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009

Title: Cruz MP. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31.

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SDS
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Tags:163521-12-8 Molecular Formula|163521-12-8 MDL|163521-12-8 SMILES|163521-12-8 Vilazodone
Catalog No.: AA001U49
163521-12-8,MFCD09838919
163521-12-8 | Vilazodone
Pack Size: 1mg
Purity: 98% by HPLC
in stock
$109.00 $76.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA001U49
Chemical Name: Vilazodone
CAS Number: 163521-12-8
Molecular Formula: C26H27N5O2
Molecular Weight: 441.5249
MDL Number: MFCD09838919
SMILES: N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2
Properties
BP: 745.1°C at 760 mmHg  
Form: Solid  
MP: 203-205 °C  
Storage: Keep in dry area;-20 ℃;  
Complexity: 729  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 33  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4  
Literature fold

Title: A review of current evidence for vilazodone in major depressive disorder.

Journal: International journal of psychiatry in clinical practice20130801

Title: Evidence for the use of vilazodone in the treatment of major depressive disorder.

Journal: Expert opinion on pharmacotherapy20121001

Title: Vilazodone for the treatment of major depressive disorder.

Journal: Pharmacotherapy20121001

Title: Vilazodone's comparative merits yet to be demonstrated.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20120915

Title: Vilazodone: a novel antidepressant.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20120915

Title: Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.

Journal: European journal of medicinal chemistry20120701

Title: Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

Journal: International journal of clinical practice20120401

Title: New drugs 2012 part I.

Journal: Nursing20120301

Title: Emerging drugs for major depressive disorder.

Journal: Expert opinion on emerging drugs20120301

Title: The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder.

Journal: Current medical research and opinion20120101

Title: Clinically significant drug interactions with newer antidepressants.

Journal: CNS drugs20120101

Title: Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder.

Journal: P & T : a peer-reviewed journal for formulary management20120101

Title: Translatability scoring in drug development: eight case studies.

Journal: Journal of translational medicine20120101

Title: Selective serotonin reuptake inhibitors (SSRIs): therapeutic drug monitoring and pharmacological interactions.

Journal: Current medicinal chemistry20120101

Title: Clinical utility of vilazodone for the treatment of adults with major depressive disorder and theoretical implications for future clinical use.

Journal: Neuropsychiatric disease and treatment20120101

Title: Pharmacological management of binge eating disorder: current and emerging treatment options.

Journal: Therapeutics and clinical risk management20120101

Title: A 1-year, open-label study assessing the safety and tolerability of vilazodone in patients with major depressive disorder.

Journal: Journal of clinical psychopharmacology20111001

Title: Vilazodone: clinical basis for the US Food and Drug Administration's approval of a new antidepressant.

Journal: The Journal of clinical psychiatry20110901

Title: A new antidepressant.

Journal: Behavioral healthcare20110901

Title: Vilazodone (Viibryd)--a new antidepressant.

Journal: The Medical letter on drugs and therapeutics20110711

Title: Vilazodone for the treatment of depression.

Journal: The Annals of pharmacotherapy20110701

Title: Vilazodone: in major depressive disorder.

Journal: CNS drugs20110701

Title: Vilazodone: a new treatment option for major depressive disorder.

Journal: Drugs of today (Barcelona, Spain : 1998)20110701

Title: A randomized, double-blind, placebo-controlled, 8-week study of vilazodone, a serotonergic agent for the treatment of major depressive disorder.

Journal: The Journal of clinical psychiatry20110401

Title: Vilazodone: another novel atypical antidepressant drug.

Journal: Journal of psychosocial nursing and mental health services20110301

Title: Vilazodone approved for major depression.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20110301

Title: Predicting impaired extinction of traumatic memory and elevated startle.

Journal: PloS one20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences20110101

Title: Vilazodone hydrochloride, linagliptin, and alcaftadine.

Journal: Journal of the American Pharmacists Association : JAPhA20110101

Title: Getting the balance right: Established and emerging therapies for major depressive disorders.

Journal: Neuropsychiatric disease and treatment20100101

Title: Vilazodone, a novel dual-acting serotonergic antidepressant for managing major depression.

Journal: Expert opinion on investigational drugs20091101

Title: Evidence for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled trial.

Journal: The Journal of clinical psychiatry20090301

Title: Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders.

Journal: CNS neuroscience & therapeutics20090101

Title: Drug evaluation: Vilazodone--a combined SSRI and 5-HT1A partial agonist for the treatment of depression.

Journal: IDrugs : the investigational drugs journal20070301

Title: Effect of vilazodone on 5-HT efflux and re-uptake in the guinea-pig dorsal raphe nucleus.

Journal: European journal of pharmacology20050704

Title: Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

Journal: European journal of pharmacology20050307

Title: Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats.

Journal: European journal of pharmacology20041103

Title: Dual 5-HT1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity.

Journal: Bioorganic & medicinal chemistry20040915

Title: Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.

Journal: Journal of medicinal chemistry20040909

Title: A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone.

Journal: Bioorganic & medicinal chemistry letters20040517

Title: Phase I and II enzyme characterization of two sources of HepG2 cell lines.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20040301

Title: Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist.

Journal: The Journal of pharmacology and experimental therapeutics20020901

Title: Distinct temporal pattern of the effects of the combined serotonin-reuptake inhibitor and 5-HT1A agonist EMD 68843 on the sleep EEG in healthy men.

Journal: Psychopharmacology20010501

Title: Systemic EMD 68843 injections reduce anxiety in the shock-probe, but not the plus-maze test.

Journal: European journal of pharmacology20010302

Title: Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009

Title: Cruz MP. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31.

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