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163847-77-6,MFCD02684280
Catalog No.:AA00AB6R

163847-77-6 | TAPI-1

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1mg
98%
in stock  
$38.00   $27.00
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10mg
≥95%(HPLC)
in stock  
$309.00   $217.00
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25mg
≥95%(HPLC)
in stock  
$468.00   $328.00
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50mg
≥95%(HPLC)
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$665.00   $465.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AB6R
Chemical Name:
TAPI-1
CAS Number:
163847-77-6
Molecular Formula:
C26H37N5O5
Molecular Weight:
499.6025
MDL Number:
MFCD02684280
SMILES:
NCCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=O)[C@@H](CC(=O)NO)CC(C)C)C
Properties
Computed Properties
 
Complexity:
746  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
13  
XLogP3:
1.3  

Literature

Title: Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice.

Journal: Toxicology and applied pharmacology 20120815

Title: Sjögren's syndrome autoantibodies provoke changes in gene expression profiles of inflammatory cytokines triggering a pathway involving TACE/NF-κB.

Journal: Laboratory investigation; a journal of technical methods and pathology 20120401

Title: Inhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111026

Title: Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20101101

Title: Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.

Journal: FEBS letters 20100702

Title: Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9.

Journal: Hepatology (Baltimore, Md.) 20100401

Title: Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma.

Journal: Experimental dermatology 20100101

Title: Release of soluble tumor necrosis factor receptor 1 from corneal epithelium by TNF-alpha-converting enzyme-dependent ectodomain shedding.

Journal: Investigative ophthalmology & visual science 20091001

Title: Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.

Journal: Journal of vascular surgery 20090501

Title: Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells.

Journal: Endocrinology 20090101

Title: Activated human neutrophils rapidly release the chemotactically active D2D3 form of the urokinase-type plasminogen activator receptor (uPAR/CD87).

Journal: Molecular and cellular biochemistry 20090101

Title: Novel approach for formation of platelet-like particles from mouse embryonic stem cells without using feeder cells.

Journal: The Kurume medical journal 20090101

Title: Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM17-like proteases.

Journal: Neuroscience letters 20081017

Title: Gamma-secretase and metalloproteinase activity regulate the distribution of endoplasmic reticulum to hippocampal neuron dendritic spines.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080801

Title: Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory.

Journal: Neurobiology of disease 20080801

Title: Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.

Journal: Molecular endocrinology (Baltimore, Md.) 20080401

Title: Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.

Journal: Developmental biology 20080401

Title: Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells.

Journal: American journal of physiology. Renal physiology 20080301

Title: Ectodomain shedding of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, by TIMP-2- and TIMP-3-sensitive proteolysis.

Journal: Journal of neurochemistry 20070901

Title: Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding.

Journal: Journal of cellular biochemistry 20061001

Title: Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium.

Journal: The Journal of biological chemistry 20060616

Title: Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.

Journal: Life sciences 20060522

Title: APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.

Journal: Journal of neurochemistry 20060501

Title: Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo.

Journal: Circulation research 20041001

Title: Tumor necrosis factor alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line.

Journal: Endocrinology 20040901

Title: Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.

Journal: Journal of molecular neuroscience : MN 20040101

Title: Tomoregulin ectodomain shedding by proinflammatory cytokines.

Journal: Life sciences 20030815

Title: Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.

Journal: The Journal of biological chemistry 20030131

Title: Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type.

Journal: European journal of immunology 20021001

Title: Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163.

Journal: Journal of leukocyte biology 20021001

Title: Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme.

Journal: The Biochemical journal 20010801

Title: A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability.

Journal: Blood 20010301

Title: Cleavage and shedding of E-cadherin after induction of apoptosis.

Journal: The Journal of biological chemistry 20010216

Title: Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010201

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