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Home Other Building Blocks 1639939-40-4
1639939-40-4,MFCD32220341
Catalog No.:AA01K5PZ

1639939-40-4 | MC-Val-Ala-PAB-PNP

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
95%
in stock  
$125.00   $88.00
- +
100mg
95%
in stock  
$178.00   $125.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01K5PZ
Chemical Name:
MC-Val-Ala-PAB-PNP
CAS Number:
1639939-40-4
Molecular Formula:
C32H37N5O10
Molecular Weight:
651.6637
MDL Number:
MFCD32220341
SMILES:
O=C(N[C@H](C(=O)N[C@H](C(=O)Nc1ccc(cc1)COC(=O)Oc1ccc(cc1)N(=O)=O)C)C(C)C)CCCCCN1C(=O)C=CC1=O
Properties

Downstream Synthesis Route

[1]CurrentPatentAssignee:MAGENTATHERAPEUTICSINC-US2014/363454,2014,A1Locationinpatent:Paragraph0296

[1]CurrentPatentAssignee:MAGENTATHERAPEUTICSINC-US2014/363454,2014,A1Locationinpatent:Paragraph0281

130878-68-1   
4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl(4-nitrophenyl)carbonate 

[1]Patent:US2014/363454,2014,A1

[1]CurrentPatentAssignee:MAGENTATHERAPEUTICSINC-US2014/363454,2014,A1

CASUnavailable 
  1639939-40-4 

[1]CurrentPatentAssignee:MAGENTATHERAPEUTICSINC-US2014/363454,2014,A1

[2]Wang,Yanming;Fan,Shiyong;Zhong,Wu;Zhou,Xinbo;Li,Song[InternationalJournalofMolecularSciences,2017,vol.18,#9]

[3]Xiao,Dian;Luo,Longlong;Li,Jiaguo;Wang,Zhihong;Liu,Lianqi;Xie,Fei;Feng,Jiannan;Zhou,Xinbo[BioorganicChemistry,2021,vol.116]

[4]Audisio,Davide;Babin,Victor;Barbe,Peggy;Beau,Fabrice;Correia,Isabelle;Devel,Laurent;Dubois,Steven;Feuillastre,Sophie;Ge,Xin;Keck,Mathilde;Lee,KiBaek;Lequin,Olivier;Malgorn,Carole;Palazzolo,Alberto;Pieters,Gregory;Sallustrau,Antoine;Thai,Robert;Cahuzac,Héloïse;Garcia-Argote,Sébastien;Nozach,Hervé[JournalofMedicinalChemistry,2022]

Literature

Title: Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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