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Home Other Building Blocks 1648863-90-4
1648863-90-4,MFCD28506227
Catalog No.:AA00ABOV

1648863-90-4 | G-5555

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%(HPLC)
in stock  
$100.00   $70.00
- +
5mg
≥98%(HPLC)
in stock  
$211.00   $148.00
- +
10mg
≥98%(HPLC)
in stock  
$290.00   $203.00
- +
25mg
≥98%(HPLC)
in stock  
$565.00   $395.00
- +
50mg
≥98%(HPLC)
in stock  
$920.00   $644.00
- +
100mg
≥98%(HPLC)
in stock  
$1,361.00   $953.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABOV
Chemical Name:
G-5555
CAS Number:
1648863-90-4
Molecular Formula:
C25H25ClN6O3
Molecular Weight:
492.9574
MDL Number:
MFCD28506227
SMILES:
CNc1ncc2c(n1)n(C[C@@H]1OC[C@H](CO1)N)c(=O)c(c2)c1ccc(cc1Cl)c1cccc(n1)C
Properties
Computed Properties
 
Complexity:
778  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.5  

Literature

Title: Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.

Title: Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.

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