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Home Other Building Blocks 1661839-45-7
1661839-45-7,MFCD29472582
Catalog No.:AA001WGC

1661839-45-7 | Cct251545

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$70.00   $49.00
- +
5mg
99%
in stock  
$211.00   $148.00
- +
10mg
99%
in stock  
$325.00   $228.00
- +
25mg
99%
in stock  
$593.00   $415.00
- +
50mg
99%
in stock  
$1,027.00   $719.00
- +
100mg
99%
in stock  
$1,449.00   $1,014.00
- +
500mg
98% by HPLC
in stock  
$7,073.00   $4,951.00
- +
1000mg
98% by HPLC
in stock  
$11,279.00   $7,896.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001WGC
Chemical Name:
Cct251545
CAS Number:
1661839-45-7
Molecular Formula:
C23H24ClN5O
Molecular Weight:
421.9226
MDL Number:
MFCD29472582
SMILES:
Cn1ncc(c1)c1ccc(cc1)c1cncc(c1N1CCC2(CC1)CCNC2=O)Cl
Properties
Computed Properties
 
Complexity:
617  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.9  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CANCERRESEARCHUK;MERCKKGAA-WO2015/144290,2015,A1

[2]Adeniji-Popoola,Olajumoke;Aherne,Wynne;Blagg,Julian;Box,Gary;Clarke,PaulA.;Court,William;Crumpler,Simon;Dale,Trevor;DeHavenBrandon,Alexis;Eccles,SuzanneA.;Esdar,Christina;Georgi,Katrin;Henley,AlanT.;Hobbs,Steve;Leuthner,Birgitta;Mallinger,Aurlie;Ortiz-Ruiz,Maria-Jesus;Pichowicz,Mark;Poeschke,Oliver;Raynaud,Florence;Rohdich,Felix;Schiemann,Kai;Smith,Elizabeth;Stieber,Frank;Stubbs,Mark;Tepoele,Robert;Thai,Ching;Valenti,Melanie;Waalboer,Dennis;Wienke,Dirk;Wood,Bozena;Workman,Paul[JournalofMedicinalChemistry,2015,vol.58,#4,p.1717-1735]

[1]CurrentPatentAssignee:CANCERRESEARCHUK;MERCKKGAA-WO2015/144290,2015,A1Locationinpatent:Page/Pagecolumn27;23;24

[2]Adeniji-Popoola,Olajumoke;Aherne,Wynne;Blagg,Julian;Box,Gary;Clarke,PaulA.;Court,William;Crumpler,Simon;Dale,Trevor;DeHavenBrandon,Alexis;Eccles,SuzanneA.;Esdar,Christina;Georgi,Katrin;Henley,AlanT.;Hobbs,Steve;Leuthner,Birgitta;Mallinger,Aurlie;Ortiz-Ruiz,Maria-Jesus;Pichowicz,Mark;Poeschke,Oliver;Raynaud,Florence;Rohdich,Felix;Schiemann,Kai;Smith,Elizabeth;Stieber,Frank;Stubbs,Mark;Tepoele,Robert;Thai,Ching;Valenti,Melanie;Waalboer,Dennis;Wienke,Dirk;Wood,Bozena;Workman,Paul[JournalofMedicinalChemistry,2015,vol.58,#4,p.1717-1735]

[1]CurrentPatentAssignee:CANCERRESEARCHUK;MERCKKGAA-WO2015/144290,2015,A1

[2]Adeniji-Popoola,Olajumoke;Aherne,Wynne;Blagg,Julian;Box,Gary;Clarke,PaulA.;Court,William;Crumpler,Simon;Dale,Trevor;DeHavenBrandon,Alexis;Eccles,SuzanneA.;Esdar,Christina;Georgi,Katrin;Henley,AlanT.;Hobbs,Steve;Leuthner,Birgitta;Mallinger,Aurlie;Ortiz-Ruiz,Maria-Jesus;Pichowicz,Mark;Poeschke,Oliver;Raynaud,Florence;Rohdich,Felix;Schiemann,Kai;Smith,Elizabeth;Stieber,Frank;Stubbs,Mark;Tepoele,Robert;Thai,Ching;Valenti,Melanie;Waalboer,Dennis;Wienke,Dirk;Wood,Bozena;Workman,Paul[JournalofMedicinalChemistry,2015,vol.58,#4,p.1717-1735]

73583-39-8   
8-{3-chloro-5-4-(1-methyl-1H-pyrazol-4-yl)-phenyl-pyridin-4-yl}-2,8-diazaspiro4.5decan-1-one 

[1]Patent:WO2015/144290,2015,A1

[1]CurrentPatentAssignee:CANCERRESEARCHUK;MERCKKGAA-WO2015/144290,2015,A1

Literature

Title: A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Journal: Nature chemical biology 20151201

Title: Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

Journal: Journal of medicinal chemistry 20150226

Title: Mallinger A, et al. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. J Med Chem. 2015 Feb 26;58(4):1717-35.

Title: Dale T, et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat Chem Biol. 2015 Dec;11(12):973-980.

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