Home Indole and Oxindoles 1670-87-7
1670-87-7,MFCD07779486
Catalog No.:AA003EBR

1670-87-7 | 1H-Indole-5-carboxamide

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Purity
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100mg
97%
in stock  
$51.00   $36.00
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250mg
97%
in stock  
$62.00   $43.00
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1g
97%
in stock  
$168.00   $117.00
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10g
≥ 98% (HPLC)
in stock  
$1,657.00   $1,160.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003EBR
Chemical Name:
1H-Indole-5-carboxamide
CAS Number:
1670-87-7
Molecular Formula:
C9H8N2O
Molecular Weight:
160.1726
MDL Number:
MFCD07779486
SMILES:
NC(=O)c1ccc2c(c1)cc[nH]2
Properties
Properties
 
BP:
457.6°C at 760 mmHg  
Form:
Solid  
MP:
159-163 °C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
193  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
0.9  

Literature

Title: p38a MAPK is involved in BMP-2-induced odontoblastic differentiation of human dental pulp cells.

Journal: International endodontic journal 20120301

Title: From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons.

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): central amino acid linker and right-hand-side SAR studies.

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication.

Journal: Experimental parasitology 20110601

Title: P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery.

Journal: Pancreas 20100501

Title: Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma.

Journal: The European respiratory journal 20100401

Title: 3D-QSAR studies of arylcarboxamides with inhibitory activity on InhA using pharmacophore-based alignment.

Journal: Chemical biology & drug design 20100201

Title: Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig.

Journal: Journal of inflammation research 20100101

Title: p38 Mitogen-activated protein kinase inhibition reduces inflammatory cytokines in a brain-dead transplant donor animal model.

Journal: Heart, lung & circulation 20091201

Title: Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat.

Journal: Journal of neuroscience research 20090301

Title: p38 MAPK inhibition reduces diabetes-induced impairment of wound healing.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

Title: Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.

Journal: European journal of pharmacology 20081214

Title: Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20080901

Title: p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation.

Journal: The Journal of pharmacology and experimental therapeutics 20080301

Title: Pharmacological properties of SD-282 - an alpha-isoform selective inhibitor for p38 MAP kinase.

Journal: Pharmacology 20080101

Title: A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model.

Journal: Journal of periodontology 20071001

Title: Improvement of human islet cryopreservation by a p38 MAPK inhibitor.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070501

Title: Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance.

Journal: Cancer research 20070501

Title: A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss.

Journal: The Journal of pharmacology and experimental therapeutics 20070101

Title: Selective inhibition of p38alpha MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury.

Journal: American journal of physiology. Heart and circulatory physiology 20061001

Title: Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages.

Journal: British journal of pharmacology 20061001

Title: Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness.

Journal: European journal of pharmacology 20060821

Title: A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis.

Journal: The Journal of pharmacology and experimental therapeutics 20060701

Title: Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes.

Journal: The Journal of pharmacology and experimental therapeutics 20060701

Title: Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses.

Journal: Cancer research 20060701

Title: Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia.

Journal: Pain 20041001

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Potent nonpeptide GnRH receptor antagonists derived from substituted indole-5-carboxamides and -acetamides bearing a pyridine side-chain terminus.

Journal: Bioorganic & medicinal chemistry letters 20010709

Title: Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul;318(1):99-107.

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