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16709-25-4,MFCD11982865
Catalog No.:AA00VQP9

16709-25-4 | alpha-Methyl-L-tryptophane hemihydrate

Pack Size
Purity
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25mg
95%
2 weeks  
$320.00   $224.00
- +
1g
95
2 weeks  
$2,027.00   $1,419.00
- +
5g
95
2 weeks  
$5,938.00   $4,157.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00VQP9
Chemical Name:
alpha-Methyl-L-tryptophane hemihydrate
CAS Number:
16709-25-4
Molecular Formula:
C12H14N2O2
Molecular Weight:
218.2518
MDL Number:
MFCD11982865
SMILES:
OC(=O)[C@](Cc1c[nH]c2c1cccc2)(N)C C12H14N2O2
Properties
Computed Properties
 
Complexity:
282  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
-0.9  

Literature

Title: Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies.

Journal: Nuclear medicine and biology 20121001

Title: Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity.

Journal: Clinical nuclear medicine 20120901

Title: Accurate differentiation of recurrent gliomas from radiation injury by kinetic analysis of α-11C-methyl-L-tryptophan PET.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120701

Title: Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: a 27-year longitudinal study.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20120601

Title: Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors.

Journal: Journal of neuro-oncology 20120401

Title: Serotonin modulates worker responsiveness to trail pheromone in the ant Pheidole dentata.

Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20120301

Title: Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design.

Journal: PloS one 20120101

Title: α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.

Journal: Biomarkers in medicine 20111001

Title: α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies.

Journal: Biomarkers in medicine 20111001

Title: Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy.

Journal: Epilepsia 20110901

Title: Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder.

Journal: Archives of general psychiatry 20110701

Title: Octopamine and occupancy: an aminergic mechanism for intruder-resident aggression in crickets.

Journal: Proceedings. Biological sciences 20110622

Title: Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications.

Journal: European journal of nuclear medicine and molecular imaging 20110301

Title: Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110201

Title: 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice.

Journal: Molecular pain 20110101

Title: Gender differences in alpha-[(11)C]MTrp brain trapping, an index of serotonin synthesis, in medication-free individuals with major depressive disorder: a positron emission tomography study.

Journal: Psychiatry research 20100830

Title: Multimodality neuroimaging in Tourette syndrome: alpha-[11C] methyl-L-tryptophan positron emission tomography and diffusion tensor imaging studies.

Journal: Journal of child neurology 20100301

Title: Brain serotonin synthesis in adult males characterized by physical aggression during childhood: a 21-year longitudinal study.

Journal: PloS one 20100101

Title: AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats.

Journal: Neurochemistry international 20091201

Title: What has positron emission tomography told us about the epileptogenic zone?

Journal: Revue neurologique 20091001

Title: Quantification of tryptophan transport and metabolism in lung tumors using PET.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090301

Title: Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography.

Journal: Alcoholism, clinical and experimental research 20090201

Title: Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats: an autoradiographic evaluation.

Journal: Brain research bulletin 20081022

Title: Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy.

Journal: The Biochemical journal 20080915

Title: Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations.

Journal: Pediatric neurology 20080901

Title: Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study.

Journal: NeuroImage 20080815

Title: Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy.

Journal: Epilepsia 20080801

Title: Alpha-[11C]methyl-L-tryptophan uptake in patients with periventricular nodular heterotopia and epilepsy.

Journal: Epilepsia 20080501

Title: An index of 5-HT synthesis changes during early antidepressant treatment: alpha-[11C]methyl-L-tryptophan PET study.

Journal: Neurochemistry international 20080101

Title: Acute flesinoxan treatment produces a different effect on rat brain serotonin synthesis than chronic treatment: an alpha-methyl-l-tryptophan autoradiographic study.

Journal: Neurochemistry international 20071201

Title: In vivo measurements of brain trapping of C-labelled alpha-methyl-L-tryptophan during acute changes in mood states.

Journal: Journal of psychiatry & neuroscience : JPN 20071101

Title: 5-Hydroxy-L-[beta-11C]tryptophan versus alpha-[11C]methyl-L-tryptophan for positron emission tomography imaging of serotonin synthesis capacity in the rhesus monkey brain.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070401

Title: Assessment of progression and treatment response of optic pathway glioma with positron emission tomography using alpha-[(11)C]methyl-L-tryptophan.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20070101

Title: Cortical trapping of alpha-[(11)C]methyl-l-tryptophan, an index of serotonin synthesis, is lower in females than males.

Journal: NeuroImage 20061115

Title: alpha-[11C]Methyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060401

Title: Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study.

Journal: Brain research bulletin 20060331

Title: In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20060301

Title: BeWo trophoblasts are unable to control replication of Toxoplasma gondii, even in the presence of exogenous IFN-gamma.

Journal: Placenta 20060101

Title: Brain regional alpha-[11C]methyl-L-tryptophan trapping correlates with post-mortem tissue serotonin content and [11C]5-hydroxytryptophan accumulation.

Journal: The international journal of neuropsychopharmacology 20051201

Title: Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using alpha-[(11)C]methyl-L-tryptophan and positron emission tomography.

Journal: Neurochemistry international 20051201

Title: The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-[14C]methyl-L-tryptophan: an autoradiographic study.

Journal: Brain research bulletin 20051015

Title: Stability of alpha-[11C]methyl-L-tryptophan brain trapping in healthy male volunteers.

Journal: European journal of nuclear medicine and molecular imaging 20051001

Title: Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study.

Journal: Psychopharmacology 20050601

Title: Serotonin synthesis by two distinct enzymes in Drosophila melanogaster.

Journal: Archives of insect biochemistry and physiology 20050501

Title: Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET).

Journal: Journal of child neurology 20050501

Title: Octopamine and experience-dependent modulation of aggression in crickets.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209

Title: Selective 5-HT1B receptor agonist reduces serotonin synthesis following acute, and not chronic, drug administration: results of an autoradiographic study.

Journal: Neurochemistry international 20050201

Title: Overexpression of the feedback-insensitive anthranilate synthase gene in tobacco causes tryptophan accumulation.

Journal: Plant cell reports 20050101

Title: Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20050101

Title: Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements.

Journal: Life sciences 20041203

Title: A simplified autoradiographic method with alpha-[14C]methyl-tryptophan to measure serotonin synthesis rate in the rat brain.

Journal: Nuclear medicine and biology 20041101

Title: Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression.

Journal: Archives of general psychiatry 20040601

Title: Effects of desipramine on regional serotonin synthesis in the rat brain: acute and chronic autoradiographic studies.

Journal: Neurochemistry international 20031201

Title: Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase.

Journal: Nature medicine 20031001

Title: Tumors hijack fetal enzyme, escape killer T cells.

Journal: Nature medicine 20031001

Title: Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy.

Journal: Neurology 20030325

Title: Alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsy.

Journal: Neurology 20030311

Title: Sex differences of brain serotonin synthesis in patients with irritable bowel syndrome using alpha-[11C]methyl-L-tryptophan, positron emission tomography and statistical parametric mapping.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20030301

Title: alpha-[11C]-Methyl-L-tryptophan PET identifies the epileptogenic tuber and correlates with interictal spike frequency.

Journal: Epilepsy research 20030101

Title: Serotonin synthesis and its light-dark variation in the rat retina.

Journal: Journal of neurochemistry 20021101

Title: The inhibition of tryptophan hydroxylase, not protein synthesis, reduces the brain trapping of alpha-methyl-L-tryptophan: an autoradiographic study.

Journal: Neurochemistry international 20020601

Title: Alpha[11C] methyl-L-typtophan positron emission tomography in patients with alternating hemiplegia of childhood.

Journal: Journal of child neurology 20020401

Title: Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study.

Journal: Journal of neurochemistry 20020301

Title: Localizing value of alpha-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin.

Journal: Neurology 20011113

Title: Study of the brain serotonergic system with labeled alpha-methyl-L-tryptophan.

Journal: Journal of neurochemistry 20010901

Title: Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system.

Journal: Journal of psychiatry & neuroscience : JPN 20010901

Title: Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010601

Title: Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder.

Journal: The American journal of psychiatry 20010501

Title: 1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase.

Journal: Archives of biochemistry and biophysics 19911201

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