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167933-07-5,MFCD00918402
Catalog No.:AA001XLY

167933-07-5 | 2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-

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5mg
≥98%
in stock  
$82.00   $57.00
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10mg
≥98%
in stock  
$153.00   $107.00
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25mg
≥98%
in stock  
$298.00   $208.00
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50mg
≥98%
in stock  
$549.00   $384.00
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100mg
98% (HPLC)
in stock  
$729.00   $510.00
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500mg
98% (HPLC)
in stock  
$3,081.00   $2,157.00
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1g
98% (HPLC)
in stock  
$5,497.00   $3,848.00
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5g
98% (HPLC)
in stock  
$24,532.00   $17,173.00
- +
25g
98% (HPLC)
in stock  
$110,190.00   $77,133.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001XLY
Chemical Name:
2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-
CAS Number:
167933-07-5
Molecular Formula:
C20H21F3N4O
Molecular Weight:
390.4021
MDL Number:
MFCD00918402
SMILES:
O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2
Properties
Computed Properties
 
Complexity:
550  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Literature

Title: Flibanserin: First Global Approval.

Journal: Drugs 20151001

Title: Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder.

Journal: CNS spectrums 20150201

Title: The 5-HT1A-receptor agonist flibanserin reduces drug-induced dyskinesia in RGS9-deficient mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20121101

Title: An update on the pharmacological management of female sexual dysfunction.

Journal: Expert opinion on pharmacotherapy 20121001

Title: Population pharmacokinetic/pharmacodynamic model for the sedative effects of flibanserin in healthy volunteers.

Journal: Pharmaceutical research 20120601

Title: Resurgence of interest in sexual dysfunction?

Journal: BJU international 20120601

Title: Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the VIOLET Study.

Journal: The journal of sexual medicine 20120401

Title: Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the DAISY study.

Journal: The journal of sexual medicine 20120301

Title: Flibanserin and 8-OH-DPAT implicate serotonin in association between female marmoset monkey sexual behavior and changes in pair-bond quality.

Journal: The journal of sexual medicine 20120301

Title: Isolation and structural elucidation of flibanserin as an adulterant in a health supplement used for female sexual performance enhancement.

Journal: Journal of pharmaceutical and biomedical analysis 20120105

Title: Flibanserin attenuates L: -DOPA-sensitized contraversive circling in the unilaterally 6-hydroxydopamine-lesioned rat model of Parkinson's disease.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20111201

Title: Satisfying sexual events as outcome measures in clinical trial of female sexual dysfunction.

Journal: The journal of sexual medicine 20111201

Title: Continued efficacy and safety of flibanserin in premenopausal women with Hypoactive Sexual Desire Disorder (HSDD): results from a randomized withdrawal trial.

Journal: The journal of sexual medicine 20111101

Title: [Depressive disorder, treatment and sexual dysfunction--part II].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20111001

Title: Gepirone-ER treatment of hypoactive sexual desire disorder (HSDD) associated with depression in women.

Journal: The journal of sexual medicine 20110501

Title: Multifunctional pharmacology of flibanserin: possible mechanism of therapeutic action in hypoactive sexual desire disorder.

Journal: The journal of sexual medicine 20110101

Title: Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness.

Journal: Molecular brain 20110101

Title: Pharmacogenetics of antidepressants.

Journal: Frontiers in pharmacology 20110101

Title: Consultation corner. The latest on female sexual health.

Journal: The Johns Hopkins medical letter health after 50 20101101

Title: [The abandonment of the development of flibanserin].

Journal: Revue medicale suisse 20101027

Title: Boehringer Ingelheim withdraws libido drug for women.

Journal: BMJ (Clinical research ed.) 20101012

Title: Do drugs have a role in turning indifference into passion?

Journal: BMJ (Clinical research ed.) 20101005

Title: Flibanserin: initial evidence of efficacy on sexual dysfunction, in patients with major depressive disorder.

Journal: The journal of sexual medicine 20101001

Title: [When women complain about lacking libido. The problem with the desire].

Journal: MMW Fortschritte der Medizin 20100902

Title: Predicting in vivo absorption behavior of oral modified release dosage forms containing pH-dependent poorly soluble drugs using a novel pH-adjusted biphasic in vitro dissolution test.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100901

Title: Flibanserin: a potential treatment for Hypoactive Sexual Desire Disorder in premenopausal women.

Journal: Women's health (London, England) 20100901

Title: Dysfunctional women remain unsexed.

Journal: BJU international 20100801

Title: [Normality of the female libido? (2)].

Journal: Revue medicale suisse 20100714

Title: Drug for low sexual desire carries significant harms, FDA advisers find.

Journal: BMJ (Clinical research ed.) 20100707

Title: [Normality of the female libido (1)].

Journal: Revue medicale suisse 20100630

Title: Flibanserin, a drug intended for treatment of hypoactive sexual desire disorder in pre-menopausal women, affects spontaneous motor activity and brain neurochemistry in female rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100601

Title: FDA advisers to assess drug for low sexual desire in women.

Journal: BMJ (Clinical research ed.) 20100525

Title: Acute and repeated flibanserin administration in female rats modulates monoamines differentially across brain areas: a microdialysis study.

Journal: The journal of sexual medicine 20100501

Title: Involvement of serotonin receptor subtypes in the antidepressant-like effect of TRIM in the rat forced swimming test.

Journal: Pharmacology, biochemistry, and behavior 20100501

Title: Modifying 5-HT1A Receptor Gene Expression as a New Target for Antidepressant Therapy.

Journal: Frontiers in neuroscience 20100101

Title: Management of hypoactive sexual desire disorder in women: current and emerging therapies.

Journal: International journal of women's health 20100101

Title: A new strategy for antidepressant prescription.

Journal: Frontiers in neuroscience 20100101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090501

Title: Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells.

Journal: The international journal of neuropsychopharmacology 20080501

Title: High-efficacy 5-HT1A agonists for antidepressant treatment: a renewed opportunity.

Journal: Journal of medicinal chemistry 20071004

Title: Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir4.1 differs in low- and high-grade human brain tumors.

Journal: Acta neuropathologica 20050401

Title: Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response.

Journal: The international journal of neuropsychopharmacology 20041201

Title: Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine.

Journal: The Journal of pharmacy and pharmacology 20040101

Title: Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors.

Journal: British journal of pharmacology 20030801

Title: Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain.

Journal: The international journal of neuropsychopharmacology 20020601

Title: Forecasting the oral absorption behavior of poorly soluble weak bases using solubility and dissolution studies in biorelevant media.

Journal: Pharmaceutical research 20020301

Title: Pharmacology of flibanserin.

Journal: CNS drug reviews 20020101

Title: Mechanism of action of flibanserin in the learned helplessness paradigm in rats.

Journal: European journal of pharmacology 20011214

Title: Further characterisation of potential antidepressant action of flibanserin.

Journal: Psychopharmacology 20011201

Title: Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats.

Journal: The international journal of neuropsychopharmacology 20010301

Title: Ex vivo binding of flibanserin to serotonin 5-HT1A and 5-HT2A receptors.

Journal: Pharmacological research 20010201

Title: Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant.

Journal: European journal of pharmacology 19971211

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Tags:167933-07-5 Molecular Formula|167933-07-5 MDL|167933-07-5 SMILES|167933-07-5 2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-