170105-16-5
[1]Miyachi,Hiroyuki;Kiyota,Hiromi;Uchiki,Hideharu;Segawa,Mitsuru[BioorganicandMedicinalChemistry,1999,vol.7,#6,p.1151-1161]
170105-16-5
[1]Miyachi,Hiroyuki;Kiyota,Hiromi;Uchiki,Hideharu;Segawa,Mitsuru[BioorganicandMedicinalChemistry,1999,vol.7,#6,p.1151-1161]
170105-16-5
[1]Miyachi,Hiroyuki;Kiyota,Hiromi;Uchiki,Hideharu;Segawa,Mitsuru[BioorganicandMedicinalChemistry,1999,vol.7,#6,p.1151-1161]
170105-16-5
[1]Miyachi,Hiroyuki;Kiyota,Hiromi;Uchiki,Hideharu;Segawa,Mitsuru[BioorganicandMedicinalChemistry,1999,vol.7,#6,p.1151-1161]
[1]CurrentPatentAssignee:KYORINHOLDINGS,INC.-US5932607,1999,A
[2]Miyachi,Hiroyuki;Kiyota,Hiromi;Uchiki,Hideharu;Segawa,Mitsuru[BioorganicandMedicinalChemistry,1999,vol.7,#6,p.1151-1161]
[3]Miyachi,Hiroyuki;Kiyota,Hiromi;Segawa,Mitsuru[BioorganicandMedicinalChemistryLetters,1999,vol.9,#20,p.3003-3008]
[4]CurrentPatentAssignee:HENANFURENMEDICALTECHDEV;KAIFENGPHARMACEUTICALGROUP;FURENMEDICINEGROUP-CN105399678,2016,ALocationinpatent:Paragraph0014;0015
Title: Characterization of muscarinic receptor binding by the novel radioligand, [(3)H]imidafenacin, in the bladder and other tissues of rats.
Journal: Journal of pharmacological sciences 20160701
Title: Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females.
Journal: Expert opinion on drug metabolism & toxicology 20121101
Title: Characterization of bladder selectivity of antimuscarinic agents on the basis of in vivo drug-receptor binding.
Journal: International neurourology journal 20120901
Title: Excitatory effect of propiverine hydrochloride on urethral activity in rats.
Journal: International journal of urology : official journal of the Japanese Urological Association 20120601
Title: Neurogenic bladder.
Journal: Advances in urology 20120101
Title: Effect of imidafenacin on nocturia and sleep disorder in patients with overactive bladder.
Journal: Urologia internationalis 20120101
Title: [Investigation of pharmacokinetics of crushed imidafenacin 0.1-mg tablet after single oral administration in healthy men].
Journal: Hinyokika kiyo. Acta urologica Japonica 20111201
Title: Effect of oxybutynin and imidafenacin on central muscarinic receptor occupancy and cognitive function: a monkey PET study with [(11)C](+)3-MPB.
Journal: NeuroImage 20110901
Title: In vivo bladder selectivity of imidafenacin, a novel antimuscarinic agent, assessed by using an effectiveness index for bladder capacity in rats.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110901
Title: Quantitative analysis of pseudopolymorphic transformation of imidafenacin by application of a novel combination of near-infrared spectroscopy and a humidity-controlled 96-well plate.
Journal: The Journal of pharmacy and pharmacology 20110701
Title: Antimuscarinics suppress adenosine triphosphate and prostaglandin E2 release from urothelium with potential improvement in detrusor overactivity in rats with cerebral infarction.
Journal: The Journal of urology 20110601
Title: Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder.
Journal: The Journal of pharmacology and experimental therapeutics 20110201
Title: [Efficacy and safety of imidafenacin in female patients with urge and mixed urinary incontinence].
Journal: Hinyokika kiyo. Acta urologica Japonica 20110101
Title: Immediate effect on overactive bladder symptoms following administration of imidafenacin.
Journal: Urologia internationalis 20110101
Title: An overview of the clinical use of antimuscarinics in the treatment of overactive bladder.
Journal: Advances in urology 20110101
Title: The efficacy and safety of propiverine hydrochloride in patients with overactive bladder symptoms who poorly responded to previous anticholinergic agents.
Journal: Advances in urology 20110101
Title: Comparative Evaluation of the Safety and Efficacy of Long-Term Use of Imidafenacin and Solifenacin in Patients with Overactive Bladder: A Prospective, Open, Randomized, Parallel-Group Trial (the LIST Study).
Journal: Advances in urology 20110101
Title: Application of a novel combination of near-infrared spectroscopy and a humidity-controlled 96-well plate to the characterization of the polymorphism of imidafenacin.
Journal: The Journal of pharmacy and pharmacology 20101101
Title: Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography.
Journal: Life sciences 20100731
Title: The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction.
Journal: Advances in urology 20100101
Title: A randomized, double-blind, placebo- and propiverine-controlled trial of the novel antimuscarinic agent imidafenacin in Japanese patients with overactive bladder.
Journal: International journal of urology : official journal of the Japanese Urological Association 20090501
Title: Comparison of the effect of anti-muscarinic agents on bladder activity, urinary ATP level, and autonomic nervous system in rats.
Journal: Biomedical research (Tokyo, Japan) 20090401
Title: Suspected differential interactions of digoxin with imidafenacin and propantheline; some thoughts for introspection.
Journal: Drug metabolism and pharmacokinetics 20090101
Title: Response to 'Suspected differential interactions of digoxin with imidafenacin and propantheline; some thoughts for introspection'.
Journal: Drug metabolism and pharmacokinetics 20090101
Title: Long-term safety, tolerability, and efficacy of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder.
Journal: International journal of urology : official journal of the Japanese Urological Association 20081001
Title: A randomized, double-blind, placebo-controlled phase II dose-finding study of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder.
Journal: International journal of urology : official journal of the Japanese Urological Association 20080901
Title: Validation and application of a 96-well format solid-phase extraction and liquid chromatography-tandem mass spectrometry method for the quantitation of digoxin in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615
Title: [Pharmacological and clinical profile of imidafenacin developed as a new therapeutic agent for overactive bladder].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080501
Title: Effect of itraconazole on the pharmacokinetics of imidafenacin in healthy subjects.
Journal: Journal of clinical pharmacology 20080301
Title: Absolute bioavailability of imidafenacin after oral administration to healthy subjects.
Journal: British journal of clinical pharmacology 20080201
Title: No effect of imidafenacin, a novel antimuscarinic drug, on digoxin pharmacokinetics in healthy subjects.
Journal: Drug metabolism and pharmacokinetics 20080101
Title: Population pharmacokinetic analysis of a novel muscarinic receptor antagonist, imidafenacin, in healthy volunteers and overactive bladder patients.
Journal: Drug metabolism and pharmacokinetics 20080101
Title: Development and validation of bioanalytical methods for imidafenacin (KRP-197/ONO-8025) and its metabolites in human urine by using liquid chromatography-tandem mass spectrometry.
Journal: Biomedical chromatography : BMC 20070901
Title: Absorption, metabolism, and excretion of [14C]imidafenacin, a new compound for treatment of overactive bladder, after oral administration to healthy male subjects.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070901
Title: Synthesis of the metabolites of 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide (KRP-197/ONO-8025).
Journal: Chemical & pharmaceutical bulletin 20070701
Title: Development and validation of bioanalytical methods for Imidafenacin (KRP-197/ONO-8025) and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615
Title: Drug-drug interactions in the metabolism of imidafenacin: role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070201
Title: Effects of imidafenacin (KRP-197/ONO-8025), a new anti-cholinergic agent, on muscarinic acetylcholine receptors. High affinities for M3 and M1 receptor subtypes and selectivity for urinary bladder over salivary gland.
Journal: Arzneimittel-Forschung 20070101
Title: Pharmacological effects of imidafenacin (KRP-197/ONO-8025), a new bladder selective anti-cholinergic agent, in rats. Comparison of effects on urinary bladder capacity and contraction, salivary secretion and performance in the Morris water maze task.
Journal: Arzneimittel-Forschung 20070101
Title: Pharmacological effects of KRP-197 on the human isolated urinary bladder.
Journal: Urologia internationalis 20030101
Title: Biomimetic oxidation of 2-methylimidazole derivative with a chemical model system for cytochrome P-450.
Journal: Chemical & pharmaceutical bulletin 20020801
Title: Muscarinic receptors of the urinary bladder: detrusor, urothelial and prejunctional.
Journal: Autonomic & autacoid pharmacology 20020601
Title: Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents.
Journal: Bioorganic & medicinal chemistry 19990601
Title: Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61.
Title: Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102.
