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170846-74-9,MFCD01321059
Catalog No.:AA00AE8X

170846-74-9 | CHPG

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5mg
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10mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AE8X
Chemical Name:
CHPG
CAS Number:
170846-74-9
Molecular Formula:
C8H8ClNO3
Molecular Weight:
201.6070
MDL Number:
MFCD01321059
SMILES:
OC(=O)C(c1cc(O)ccc1Cl)N
Properties
Properties
 
Form:
Solid  

Computed Properties
 
Complexity:
200  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-1.4  

Literature

Title: Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model.

Journal: Toxicology letters 20180515

Title: Involvement of metabotropic glutamate receptor 5 signaling in activity-related proliferation of adult hippocampal neural stem cells.

Journal: The European journal of neuroscience 20120801

Title: Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury.

Journal: Brain research 20120629

Title: Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501

Title: Protective effects of mGluR5 positive modulators against traumatic neuronal injury through PKC-dependent activation of MEK/ERK pathway.

Journal: Neurochemical research 20120501

Title: DHEAS induces short-term potentiation via the activation of a metabotropic glutamate receptor in the rat hippocampus.

Journal: Hippocampus 20120401

Title: The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway.

Journal: International journal of molecular medicine 20120401

Title: NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120201

Title: The increased expression of metabotropic glutamate receptor 5 in subventricular zone neural progenitor cells and enhanced neurogenesis in a rat model of intracerebral hemorrhage.

Journal: Neuroscience 20120127

Title: Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury.

Journal: Journal of neuroinflammation 20120101

Title: The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency.

Journal: BMC pharmacology 20120101

Title: Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110413

Title: Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function.

Journal: Brain research 20101001

Title: Distinct modes of modulation of GABAergic transmission by Group I metabotropic glutamate receptors in rat entorhinal cortex.

Journal: Hippocampus 20100801

Title: The metabotropic glutamate mGluR5 receptor agonist CHPG stimulates food intake.

Journal: Neuroreport 20100714

Title: Modulation of intracellular calcium mobilization and GABAergic currents through subtype-specific metabotropic glutamate receptors in neonatal rat hippocampus.

Journal: Brain research bulletin 20100115

Title: Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.

Journal: Journal of neurochemistry 20090901

Title: Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents.

Journal: Annals of neurology 20090701

Title: Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase.

Journal: The Journal of biological chemistry 20090605

Title: Differential metabotropic glutamate receptor expression and modulation in two neocortical inhibitory networks.

Journal: Journal of neurophysiology 20090501

Title: Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.

Journal: Glia 20090401

Title: Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.

Journal: Journal of biomedical science 20090101

Title: Inhibition of MPEP on the development of morphine antinociceptive tolerance and the biosynthesis of neuronal nitric oxide synthase in rat spinal cord.

Journal: Neuroscience letters 20080509

Title: Activation of NF-kappaB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP(+) toxicity in SK-N-SH cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20080501

Title: Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice.

Journal: Psychopharmacology 20080501

Title: Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat.

Journal: Neuroscience letters 20070613

Title: No improvement of functional and histological outcome after application of the metabotropic glutamate receptor 5 agonist CHPG in a model of endothelin-1-induced focal ischemia in rats.

Journal: Neuroscience research 20070401

Title: Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503

Title: Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors.

Journal: British journal of anaesthesia 20060501

Title: Pharmacological treatment to augment hole board habituation in prenatal Vitamin D-deficient rats.

Journal: Behavioural brain research 20060106

Title: Developmental switch from LTD to LTP in low frequency-induced plasticity.

Journal: Hippocampus 20060101

Title: An ionotropic but not a metabotropic glutamate agonist potentiates the pharmacological effects of olanzapine in the rat.

Journal: Behavioural pharmacology 20051201

Title: Calcium from internal stores triggers GABA release from retinal amacrine cells.

Journal: Journal of neurophysiology 20051201

Title: Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects.

Journal: Journal of neurochemistry 20051101

Title: Role of group II metabotropic glutamate receptors 2/3 and group I metabotropic glutamate receptor 5 in developing rat medial vestibular nuclei.

Journal: Neuroreport 20050822

Title: NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity.

Journal: Cell death and differentiation 20050701

Title: Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.

Journal: British journal of pharmacology 20050601

Title: Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats: possible relevance to the effects of mGlu5R blockade in Parkinson's disease.

Journal: Journal of neuroscience research 20050601

Title: Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413

Title: Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons.

Journal: The Journal of biological chemistry 20050401

Title: Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells.

Journal: The European journal of neuroscience 20050101

Title: Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum.

Journal: Journal of neurochemistry 20040901

Title: MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor.

Journal: Journal of neurochemistry 20040601

Title: Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons.

Journal: Journal of neurophysiology 20040101

Title: Activation of metabotropic glutamate receptor 5 is associated with effect of amphetamine on brain neurons.

Journal: Synapse (New York, N.Y.) 20031215

Title: Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents.

Journal: The Journal of pharmacology and experimental therapeutics 20030701

Title: Regulation of kainate receptors by protein kinase C and metabotropic glutamate receptors.

Journal: The Journal of physiology 20030501

Title: Metabotropic glutamate receptor 5-regulated Elk-1 phosphorylation and immediate early gene expression in striatal neurons.

Journal: Journal of neurochemistry 20030501

Title: Preproenkephalin mRNA expression in rat dorsal striatum induced by selective activation of metabotropic glutamate receptor subtype-5.

Journal: Synapse (New York, N.Y.) 20030315

Title: Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats.

Journal: European journal of pharmacology 20030221

Title: Activation of mGluR5 modulates GABA(A) receptor function in retinal amacrine cells.

Journal: Journal of neurophysiology 20021001

Title: Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei.

Journal: The Journal of physiology 20020915

Title: Mechanisms and physiological role of enhancement of mGlu5 receptor function by group II mGlu receptor activation in rat perirhinal cortex.

Journal: The Journal of physiology 20020501

Title: Interaction of group I mGlu and NMDA receptor agonists within the dorsal horn of the spinal cord of the juvenile rat.

Journal: British journal of pharmacology 20020501

Title: Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia.

Journal: Brain research 20011220

Title: The selective mGlu(5) receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopamine-lesioned rats and modulates the binding characteristics of dopamine D(2) receptors in the rat striatum: interactions with adenosine A(2a) receptors.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011001

Title: Effect of the group I metabotropic glutamate agonist DHPG on the visual cortex.

Journal: Journal of neurophysiology 20011001

Title: Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.

Journal: Journal of neuroendocrinology 20010801

Title: Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons.

Journal: Neuropharmacology 20010301

Title: Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

Journal: Neuroscience 20010101

Title: Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.

Journal: Journal of neurochemistry 20001201

Title: Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).

Journal: Neuropharmacology 20000710

Title: Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity.

Journal: Neuropharmacology 19990701

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