Home Sulfonamines 170858-33-0
170858-33-0,MFCD19443868
Catalog No.:AA00ACIL

170858-33-0 | Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-

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1mg
≥98%
in stock  
$63.00   $44.00
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5mg
≥98%
in stock  
$156.00   $109.00
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10mg
≥98%
in stock  
$276.00   $193.00
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50mg
≥98%(HPLC)
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$1,115.00   $780.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ACIL
Chemical Name:
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
CAS Number:
170858-33-0
Molecular Formula:
C21H27N3O3S
Molecular Weight:
401.5224
MDL Number:
MFCD19443868
SMILES:
NS(=O)(=O)c1ccc(cc1)N1CCN(CC1)CC[C@@H]1OCCc2c1cccc2
Properties
Computed Properties
 
Complexity:
593  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Literature

Title: WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation.

Journal: Behavioural pharmacology 20090201

Title: Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole), a dopamine D4 receptor antagonist and serotonin reuptake inhibitor: characterisation of its in vitro profile and pre-clinical antipsychotic potential.

Journal: European journal of pharmacology 20071114

Title: Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain.

Journal: Molecular pharmacology 20041201

Title: Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial.

Journal: Biological psychiatry 20040301

Title: Dopamine D4 receptor-deficient mice display cortical hyperexcitability.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010601

Title: Current and novel approaches to the drug treatment of schizophrenia.

Journal: Journal of medicinal chemistry 20010215

Title: Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor.

Journal: European journal of pharmacology 19970319

Title: Mark H Corrigan, et al. Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial. Biol Psychiatry. 2004 Mar 1;55(5):445-51.

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Tags:170858-33-0 Molecular Formula|170858-33-0 MDL|170858-33-0 SMILES|170858-33-0 Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-