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171714-84-4,MFCD00949063
Catalog No.:AA00ACIN

171714-84-4 | Darusentan

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$7.00   $5.00
- +
5mg
99+%
in stock  
$13.00   $9.00
- +
10mg
99+%
in stock  
$17.00   $12.00
- +
50mg
99+%
in stock  
$51.00   $36.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ACIN
Chemical Name:
Darusentan
CAS Number:
171714-84-4
Molecular Formula:
C22H22N2O6
Molecular Weight:
410.4199
MDL Number:
MFCD00949063
SMILES:
COC(C(C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1
Properties

Downstream Synthesis Route

[1]Patent:WO2013/57468,2013,A1.Locationinpatent:Page/Pagecolumn23

[2]Patent:WO2010/70658,2010,A2.Locationinpatent:Page/Pagecolumn23-24

[3]Patent:US2011/263854,2011,A1.Locationinpatent:Page/Pagecolumn9-10

[1]Patent:US2011/263854,2011,A1

[2]OrganicProcessResearchandDevelopment,2001,vol.5,p.16-22

[1]Patent:US2011/263854,2011,A1

[2]Patent:WO2013/57468,2013,A1

[1]Patent:US2011/263854,2011,A1

[2]Patent:WO2013/57468,2013,A1

[3]OrganicProcessResearchandDevelopment,2001,vol.5,p.16-22

Literature

Title: Frank Enseleit, et al. Darusentan, a selective endothelin A receptor antagonist, for the oral treatment of resistant hypertension. Ther Adv Cardiovasc Dis. 2010 Aug;4(4):231-40.

Title: Liang F, et al. Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries. Can J Physiol Pharmacol. 2010 Aug;88(8):840-9.

Title: H H Dao, et al. Norepinephrine-induced aortic hyperplasia and extracellular matrix deposition are endothelin-dependent. J Hypertens. 2001 Nov;19(11):1965-73.

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SDS
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