Home Quinolines 174635-69-9
174635-69-9,MFCD00944072
Catalog No.:AA001ZRI

174635-69-9 | 4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $11.00
- +
5mg
98%
in stock  
$54.00   $38.00
- +
10mg
98%
in stock  
$82.00   $57.00
- +
100mg
95%
in stock  
$199.00   $139.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001ZRI
Chemical Name:
4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-
CAS Number:
174635-69-9
Molecular Formula:
C26H24N2O
Molecular Weight:
380.4816
MDL Number:
MFCD00944072
SMILES:
CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1
Properties
Properties
 
Form:
Solid  
MP:
154℃  
Solubility:
DMSO: ~28 mg/mL, soluble  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
523  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
5.9  

Literature

Title: Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Journal: European journal of medicinal chemistry 20130501

Title: Blockade of tachykinin NK3 receptor reverses hypertension through a dopaminergic mechanism in the ventral tegmental area of spontaneously hypertensive rats.

Journal: British journal of pharmacology 20101201

Title: NK-3 receptor antagonism prevents behavioral sensitization to cocaine: a role of glycogen synthase kinase-3 in the nucleus accumbens.

Journal: Journal of neurochemistry 20101101

Title: A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20100223

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Blockade of neurokinin-3 receptors modulates dopamine-mediated behavioral hyperactivity.

Journal: Neuropharmacology 20090901

Title: New quinoline NK3 receptor antagonists with CNS activity.

Journal: Bioorganic & medicinal chemistry letters 20090201

Title: The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils.

Journal: European journal of pharmacology 20081214

Title: cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Journal: Journal of medicinal chemistry 20081127

Title: Localization and function of NK(3) subtype tachykinin receptors of layer V pyramidal neurons of the guinea-pig medial prefrontal cortex.

Journal: Neuroscience 20081028

Title: Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats.

Journal: European journal of pharmacology 20080820

Title: Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease.

Journal: Neuropharmacology 20080601

Title: Functionalization through lithiation of (S)-N-(1-phenylpropyl)-2-phenylquinoline-4-carboxamide. Application to the labeling with carbon-11 of NK-3 receptor antagonist SB 222200.

Journal: The Journal of organic chemistry 20070316

Title: Neurokinin-3 receptor-specific antagonists talnetant and osanetant show distinct mode of action in cellular Ca2+ mobilization but display similar binding kinetics and identical mechanism of binding in ligand cross-competition.

Journal: Molecular pharmacology 20070301

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret.

Journal: Neuroscience letters 20050307

Title: Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110

Title: Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin.

Journal: Peptides 20041101

Title: Role of tachykinin receptors in the central processing of afferent input from the acid-threatened rat stomach.

Journal: Regulatory peptides 20011215

Title: Contribution of NK3 tachykinin receptors to propulsion in the rabbit isolated distal colon.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20010601

Title: Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.

Journal: European journal of pharmacology 20010216

Title: Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.

Journal: The Journal of pharmacology and experimental therapeutics 20001001

Title: 2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.

Journal: Journal of medicinal chemistry 19960607

Title: Sarau HM, et al. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J Pharmacol Exp Ther. 2000 Oct;295(1):373-81.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 174635-69-9
Tags:174635-69-9 Molecular Formula|174635-69-9 MDL|174635-69-9 SMILES|174635-69-9 4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-