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Home Quinolines 174636-32-9
174636-32-9,MFCD00944075
Catalog No.:AA001ZRH

174636-32-9 | 4-Quinolinecarboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$29.00   $20.00
- +
5mg
98%
in stock  
$75.00   $53.00
- +
100mg
95%
in stock  
$103.00   $72.00
- +
250mg
95%
in stock  
$218.00   $152.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001ZRH
Chemical Name:
4-Quinolinecarboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-
CAS Number:
174636-32-9
Molecular Formula:
C25H22N2O2
Molecular Weight:
382.4544
MDL Number:
MFCD00944075
SMILES:
CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1
Properties
Properties
 
BP:
580.4°C at 760 mmHg  
Form:
Solid  
MP:
115 - 120°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
527  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
5.7  

Downstream Synthesis Route

[1]OrganicLetters,2010,vol.12,p.1984-1987

[2]OrganicLetters,2007,vol.9,p.5525-5528

[3]JournalofMedicinalChemistry,1996,vol.39,p.2281-2284

5050-41-9    174636-32-9   
2-Phenyl-3-(2-pyrrolidin-1-yl-ethoxy)-quinoline-4-carboxylicacid((S)-1-phenyl-propyl)-amide 

[1]JournalofMedicinalChemistry,1999,vol.42,p.1053-1065

683-57-8    174636-32-9   
3-Carbamoylmethoxy-2-phenyl-quinoline-4-carboxylicacid((S)-1-phenyl-propyl)-amide 

[1]JournalofMedicinalChemistry,1999,vol.42,p.1053-1065

3789-59-1   
3-hydroxy-2-phenyl-quinoline-4-carbonylchloride 
  174636-32-9 

[1]JournalofMedicinalChemistry,1999,vol.42,p.1053-1065

[1]JournalofMedicinalChemistry,1999,vol.42,p.1053-1065

[2]Patent:US6277862,2001,B1

Literature

Title: Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412). J Med Chem. 1999 Mar 25;42(6):1053-65.

Title: Houghton LA, et al. Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans. Neurogastroenterol Motil. 2007 Sep;19(9):732-43.

Title: Dawson LA, et al. In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia. Neuropsychopharmacology. 2008 Jun;33(7):1642-52.

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SDS
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Tags:174636-32-9 Molecular Formula|174636-32-9 MDL|174636-32-9 SMILES|174636-32-9 4-Quinolinecarboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-