Title: Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.
Journal: British journal of pharmacology 20150101
Title: Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Journal: Circulation research 20120803
Title: Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20120701
Title: The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine.
Journal: The Journal of physiology 20120615
Title: Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.
Journal: Endocrinology 20120301
Title: Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium.
Journal: The Journal of biological chemistry 20120106
Title: Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells.
Journal: PloS one 20120101
Title: Calcium-sensing receptor modulates cell adhesion and migration via integrins.
Journal: The Journal of biological chemistry 20111125
Title: Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis.
Journal: Kidney international 20110901
Title: Calcimimetics inhibit renal pathology in rodent nephronophthisis.
Journal: Kidney international 20110901
Title: Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion.
Journal: The Journal of pharmacology and experimental therapeutics 20110601
Title: Effects of calcimimetic combined with an angiotensin-converting enzyme inhibitor on uremic cardiomyopathy progression.
Journal: American journal of nephrology 20110101
Title: Calcimimetic R-568 effects on activity of R990G polymorphism of calcium-sensing receptor.
Journal: Journal of molecular endocrinology 20101001
Title: Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retention.
Journal: The Journal of biological chemistry 20100625
Title: Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis.
Journal: Anatomical record (Hoboken, N.J. : 2007) 20100501
Title: Functional expression of the extracellular-Ca2+-sensing receptor in mouse taste cells.
Journal: Journal of cell science 20100315
Title: Residue 826 in the calcium-sensing receptor is implicated in the response to calcium and to R-568 calcimimetic compound.
Journal: Calcified tissue international 20100301
Title: Differential modulation of intracellular Ca2+ responses associated with calcium-sensing receptor activation in renal collecting duct cells.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor.
Journal: The Journal of pharmacology and experimental therapeutics 20091201
Title: Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics.
Journal: Journal of medicinal chemistry 20091112
Title: Calcium-sensing receptors modulate renin release in vivo and in vitro in the rat.
Journal: Journal of hypertension 20091001
Title: Human PTH gene regulation in vivo using transgenic mice.
Journal: American journal of physiology. Renal physiology 20090901
Title: R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD).
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090801
Title: The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice.
Journal: Atherosclerosis 20090701
Title: Acute cardiovascular effects of the calcimimetic R-568 and its enantiomer S-568 in rats.
Journal: Pediatric nephrology (Berlin, Germany) 20090701
Title: The corpuscles of Stannius, calcium-sensing receptor, and stanniocalcin: responses to calcimimetics and physiological challenges.
Journal: Endocrinology 20090701
Title: Calcimimetic inhibits late-stage cyst growth in ADPKD.
Journal: Journal of the American Society of Nephrology : JASN 20090701
Title: Type II calcimimetics and polycystic kidney disease: unanswered questions.
Journal: Journal of the American Society of Nephrology : JASN 20090701
Title: Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic.
Journal: Laboratory investigation; a journal of technical methods and pathology 20090501
Title: Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD.
Journal: American journal of physiology. Renal physiology 20090401
Title: Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090201
Title: Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells.
Journal: Cardiovascular research 20090201
Title: The new role of calcimimetics as vasculotropic agents.
Journal: Kidney international 20090101
Title: A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia.
Journal: Kidney international 20090101
Title: Calcimimetics normalize the phosphate-induced stimulation of PTH secretion in vivo and in vitro.
Journal: Journal of nephrology 20090101
Title: The calcimimetic R-568 induces apoptotic cell death in prostate cancer cells.
Journal: Journal of experimental & clinical cancer research : CR 20090101
Title: [Calcimimetic or calcitriol? A new class struggle].
Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20090101
Title: Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR.
Journal: The Journal of physiology 20081215
Title: The extracellular Ca2+-sensing receptor branches out--a new role in lung morphogenesis.
Journal: The Journal of physiology 20081215
Title: Novel inactivating mutations of the calcium-sensing receptor: the calcimimetic NPS R-568 improves signal transduction of mutant receptors.
Journal: The Journal of clinical endocrinology and metabolism 20081201
Title: Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats.
Journal: American journal of physiology. Renal physiology 20080401
Title: N-isopropylsulfinylimines as useful intermediates in the synthesis of chiral amines: expeditive asymmetric synthesis of the calcimimetic (+)-NPS R-568.
Journal: The Journal of organic chemistry 20080118
Title: Destabilization of parathyroid hormone mRNA by extracellular Ca2+ and the calcimimetic R-568 in parathyroid cells: role of cytosolic Ca and requirement for gene transcription.
Journal: Journal of molecular endocrinology 20080101
Title: CKD-MBD: impact on management of kidney disease.
Journal: Clinical and experimental nephrology 20071201
Title: Activation of calcium-sensing receptor accelerates apoptosis in hyperplastic parathyroid cells.
Journal: Biochemical and biophysical research communications 20071012
Title: The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands.
Journal: American journal of physiology. Renal physiology 20070501
Title: Calcium sensing receptor activators: calcimimetics.
Journal: Current medicinal chemistry 20070101
Title: Calcification inhibitors and Wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin D sterols.
Journal: Calcified tissue international 20061201
Title: Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases.
Journal: The Journal of endocrinology 20060901
Title: [Calcium receptor/calcium-sensing receptor].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060901
Title: Meta-analysis of biochemical and patient-level effects of calcimimetic therapy.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20060501
Title: Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism.
Journal: Pharmacology & therapeutics 20060301
Title: Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats.
Journal: Journal of the American Society of Nephrology : JASN 20060301
Title: Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol.
Journal: Journal of the American Society of Nephrology : JASN 20060301
Title: Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1.
Journal: Journal of the American Society of Nephrology : JASN 20060101
Title: Pharmacological activity of calcimimetic NPS R-568 administered intravenously in rats: dose dependency.
Journal: Pharmacological reports : PR 20060101
Title: Role of calcium-phosphorous disorders in the progression of renal failure.
Journal: Kidney international. Supplement 20051201
Title: Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+).
Journal: The Journal of biological chemistry 20051104
Title: [Calcimimetics, mechanisms of action and therapeutic applications].
Journal: Presse medicale (Paris, France : 1983) 20050910
Title: [Apoptosis: a possible mechanism of suppressing parathyroid hyperplasia by calcimimetics].
Journal: Clinical calcium 20050901
Title: [Management of secondary hyperparathyroidism].
Journal: Clinical calcium 20050901
Title: Calcimimetics: a new tool for management of hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease.
Journal: Kidney international. Supplement 20050601
Title: [Calcimimetics--a new treatment for hyperparathyroidism?].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050501
Title: Functional proteins involved in regulation of intracellular Ca(2+) for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetics.
Journal: Journal of pharmacological sciences 20050301
Title: Calcimimetic NPS R-568 induces hypotensive effect in spontaneously hypertensive rats.
Journal: American journal of hypertension 20050301
Title: Calcimimetics and the treatment of primary and secondary hyperparathyroidism.
Journal: The Annals of pharmacotherapy 20041101
Title: Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency.
Journal: Journal of the American Society of Nephrology : JASN 20041001
Title: Calcimimetics and hyperparathyroidism.
Journal: Current opinion in investigational drugs (London, England : 2000) 20041001
Title: Calcimimetic agents for the treatment of secondary hyperparathyroidism.
Journal: Seminars in nephrology 20040901
Title: Enantioselective synthesis of primary 1-(aryl)alkylamines by nucleophilic 1,2-addition of organolithium reagents to hydroxyoxime ethers and application to asymmetric synthesis of G-protein-coupled receptor ligands.
Journal: The Journal of organic chemistry 20040820
Title: Modulation and action of the calcium-sensing receptor.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040801
Title: A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040501
Title: Calcimimetic and calcilytic drugs: just for parathyroid cells?
Journal: Cell calcium 20040301
Title: [Bone status in primary hyperparathyroidism].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040201
Title: Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials.
Journal: Pediatric nephrology (Berlin, Germany) 20031201
Title: Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20031001
Title: Calcimimetic agents: review and perspectives.
Journal: Kidney international. Supplement 20030601
Title: Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors.
Journal: Journal of the American Society of Nephrology : JASN 20030401
Title: [Calcimimetic agents in the treatment of hyperparathyroidism secondary to chronic renal failure].
Journal: Medicina 20030101
Title: [Calcimimmetic and calcilytics: new perspectives of correction of abnormal parathormone (PTH) secretion].
Journal: Przeglad lekarski 20030101
Title: Calcium sensing receptor activation by a calcimimetic suggests a link between cooperativity and intracellular calcium oscillations.
Journal: The Journal of biological chemistry 20021220
Title: Calcimimetics: therapeutic potential in hyperparathyroidism.
Journal: Current opinion in pharmacology 20021201
Title: Calcimimetics in the treatment of primary hyperparathyroidism.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101
Title: Physiological and pharmacological agonists of the extracellular Ca2+-sensing receptor.
Journal: European journal of pharmacology 20020705
Title: Future role of calcimimetics in end-stage renal disease.
Journal: Advances in renal replacement therapy 20020701
Title: Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor.
Journal: The Journal of biological chemistry 20020524
Title: [Bone changes in primary hyperparathyroidism].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020301
Title: Calcimimetic agents and secondary hyperparathyroidism: treatment and prevention.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020201
Title: Treatment of secondary hyperparathyroidism with vitamin D derivatives and calcimimetics before and after start of dialysis.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020101
Title: Criteria for calcimimetic agent in the treatment of more severe secondary hyperparathyroidism.
Journal: Kidney international 20010101
Title: Prevention of uremic bone disease using calcimimetic compounds.
Journal: Annual review of medicine 20010101
Title: Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors.
Journal: Endocrinology 20001101
Title: Calcimimetics with potent and selective activity on the parathyroid calcium receptor.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19980331
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