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178064-02-3,MFCD01318816
Catalog No.:AA00APRJ

178064-02-3 | NOCICEPTIN (1-13) AMIDE

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5mg
>98%(HPLC)
2 weeks  
$304.00   $213.00
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10mg
>98%(HPLC)
2 weeks  
$388.00   $272.00
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25mg
>98%(HPLC)
2 weeks  
$511.00   $358.00
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50mg
>98%(HPLC)
2 weeks  
$693.00   $485.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00APRJ
Chemical Name:
NOCICEPTIN (1-13) AMIDE
CAS Number:
178064-02-3
MDL Number:
MFCD01318816
Properties
Computed Properties
 
Complexity:
2650  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
98  
Hydrogen Bond Acceptor Count:
20  
Hydrogen Bond Donor Count:
22  
Rotatable Bond Count:
47  
XLogP3:
-7  

Literature

Title: The nociceptin system and hippocampal cognition in mice: a pharmacological and genetic analysis.

Journal: Brain research 20091211

Title: Are nociceptin(1-13)NH2 and its structural analogue [ORN(9)]nociceptin(1-13)NH2 able to affect brain antioxidant status in control and kainic acid-treated rats?

Journal: Cell biochemistry and function 20090601

Title: Study of the cytotoxicity and antioxidant capacity of N/OFQ(1-13)NH2 and its structural analogues.

Journal: Pharmacological reports : PR 20090101

Title: Nociceptin (1-13)NH2 inhibits stimulated calcitonin-gene-related-peptide release from primary cultures of rat trigeminal ganglia neurones.

Journal: Cephalalgia : an international journal of headache 20070801

Title: Role of hypothalamus nociceptin/orphanin FQ in pre-ovulatory luteinizing hormone surge of estrogen and progesterone-primed, ovariectomized rats.

Journal: Acta pharmacologica Sinica 20070801

Title: Interaction between nociceptin/orphanin FQ (N/OFQ) and GABA in response to feeding.

Journal: Physiology & behavior 20061030

Title: Synthesis and biological activity of nociceptin/orphanin FQ(1-13)NH2 analogues modified in 9 and/or 13 position.

Journal: Bioorganic & medicinal chemistry letters 20060801

Title: Partial agonist behaviour depends upon the level of nociceptin/orphanin FQ receptor expression: studies using the ecdysone-inducible mammalian expression system.

Journal: British journal of pharmacology 20030901

Title: Nociceptin/Orphanin FQ(1-13)NH2 analogues modified in the Phe1-Gly2 peptide bond.

Journal: Bioorganic & medicinal chemistry letters 20030210

Title: Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice.

Journal: Neuroscience letters 20021011

Title: Comparison of the binding of [(3)H]nociceptin/orphaninFQ(1-13)NH(2), [(3)H]nociceptin/orphaninFQ(1-17)OH and [(125)I]Tyr(14)nociceptin/orphaninFQ(1-17)OH to recombinant human and native rat cerebrocortical nociceptin/orphanin FQ receptors.

Journal: Neuroscience letters 20020802

Title: Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020601

Title: NOC/oFQ and NMDA contribute to piglet hypoxic ischemic hypotensive cerebrovasodilation impairment.

Journal: Pediatric research 20020501

Title: Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized rats.

Journal: European journal of pharmacology 20020419

Title: [Nphe(1)]N/OFQ-(1-13)-NH(2) is a competitive and selective antagonist at nociceptin/orphanin FQ receptors mediating K(+) channel activation in rat periaqueductal gray slices.

Journal: Neuropharmacology 20020201

Title: Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor.

Journal: Journal of medicinal chemistry 20011108

Title: Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nociceptin peptides.

Journal: Journal of medicinal chemistry 20011108

Title: Comparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors.

Journal: British journal of pharmacology 19990501

Title: Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

Journal: Journal of medicinal chemistry 19970606

Title: Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90.

Title: Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.

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