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180002-83-9,MFCD08061200
Catalog No.:AA0021IA

180002-83-9 | Methanone, (2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-

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1mg
≥98%
in stock  
$49.00   $34.00
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5mg
≥98%
in stock  
$122.00   $85.00
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10mg
≥98%
in stock  
$168.00   $117.00
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25mg
≥98%
in stock  
$356.00   $249.00
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100mg
97%
in stock  
$1,001.00   $701.00
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250mg
97%
in stock  
$1,636.00   $1,145.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0021IA
Chemical Name:
Methanone, (2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-
CAS Number:
180002-83-9
Molecular Formula:
C23H24Cl2N2O3
Molecular Weight:
447.3543
MDL Number:
MFCD08061200
SMILES:
COc1ccc2c(c1)c(CCN1CCOCC1)c(n2C(=O)c1cccc(c1Cl)Cl)C
Properties
Computed Properties
 
Complexity:
589  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
5.1  

Literature

Title: Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.

Journal: Journal of medicinal chemistry 20131114

Title: Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives.

Journal: Bioorganic & medicinal chemistry 20110915

Title: Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging.

Journal: Bioorganic & medicinal chemistry 20110801

Title: Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.

Journal: Bioorganic & medicinal chemistry letters 20110415

Title: Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism.

Journal: Cell death & disease 20110401

Title: Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.

Journal: European journal of medicinal chemistry 20110201

Title: Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.

Journal: Osteoarthritis and cartilage 20101101

Title: Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.

Journal: Neuropharmacology 20050401

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain.

Journal: Pain 20020401

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Tags:180002-83-9 Molecular Formula|180002-83-9 MDL|180002-83-9 SMILES|180002-83-9 Methanone, (2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-