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1800398-38-2,MFCD31657408
Catalog No.:AA01EOGM

1800398-38-2 | Lxh254

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$37.00   $26.00
- +
5mg
97%
in stock  
$93.00   $65.00
- +
10mg
97%
in stock  
$138.00   $96.00
- +
25mg
97%
in stock  
$226.00   $158.00
- +
100mg
97%
in stock  
$601.00   $421.00
- +
250mg
97%
in stock  
$1,009.00   $706.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EOGM
Chemical Name:
Lxh254
CAS Number:
1800398-38-2
Molecular Formula:
C25H25F3N4O4
Molecular Weight:
502.4856
MDL Number:
MFCD31657408
SMILES:
OCCOc1cc(cc(n1)N1CCOCC1)c1cc(ccc1C)NC(=O)c1ccnc(c1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
709  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
3.2  

Downstream Synthesis Route
1800398-38-2   
CASUnavailable 

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-US2016/75727,2016,A1Locationinpatent:Paragraph0123;0124

[1]Ramurthy,Savithri;Taft,BenjaminR.;Aversa,RobertJ.;Barsanti,PaulA.;Burger,MatthewT.;Lou,Yan;Nishiguchi,GiseleA.;Rico,Alice;Setti,Lina;Smith,Aaron;Subramanian,Sharadha;Tamez,Victoriano;Tanner,Huw;Wan,Lifeng;Hu,Cheng;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Tellew,JohnE.;Huang,Shenlin;Yue,Qin;Chaudhary,Apurva;Tian,Hung;Iyer,Raman;Hassan,A.Quamrul;MathewsGriner,LesleyA.;LaBonte,LauraR.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Mishina,Yuji;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Sellers,WilliamR.;Lees,Emma;Shao,Wenlin;Dillon,MichaelP.;Stuart,DarrinD.[JournalofMedicinalChemistry,2020,vol.63,#5,p.2013-2027]

[2]Ramurthy,Savithri;Taft,BenjaminR.;Aversa,RobertJ.;Barsanti,PaulA.;Burger,MatthewT.;Lou,Yan;Nishiguchi,GiseleA.;Rico,Alice;Setti,Lina;Smith,Aaron;Subramanian,Sharadha;Tamez,Victoriano;Tanner,Huw;Wan,Lifeng;Hu,Cheng;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Tellew,JohnE.;Huang,Shenlin;Yue,Qin;Chaudhary,Apurva;Tian,Hung;Iyer,Raman;Hassan,A.Quamrul;MathewsGriner,LesleyA.;LaBonte,LauraR.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Mishina,Yuji;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Sellers,WilliamR.;Lees,Emma;Shao,Wenlin;Dillon,MichaelP.;Stuart,DarrinD.[JournalofMedicinalChemistry,2020,vol.63,#5,p.2013-2027]

[1]Ramurthy,Savithri;Taft,BenjaminR.;Aversa,RobertJ.;Barsanti,PaulA.;Burger,MatthewT.;Lou,Yan;Nishiguchi,GiseleA.;Rico,Alice;Setti,Lina;Smith,Aaron;Subramanian,Sharadha;Tamez,Victoriano;Tanner,Huw;Wan,Lifeng;Hu,Cheng;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Tellew,JohnE.;Huang,Shenlin;Yue,Qin;Chaudhary,Apurva;Tian,Hung;Iyer,Raman;Hassan,A.Quamrul;MathewsGriner,LesleyA.;LaBonte,LauraR.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Mishina,Yuji;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Sellers,WilliamR.;Lees,Emma;Shao,Wenlin;Dillon,MichaelP.;Stuart,DarrinD.[JournalofMedicinalChemistry,2020,vol.63,#5,p.2013-2027]

[2]Ramurthy,Savithri;Taft,BenjaminR.;Aversa,RobertJ.;Barsanti,PaulA.;Burger,MatthewT.;Lou,Yan;Nishiguchi,GiseleA.;Rico,Alice;Setti,Lina;Smith,Aaron;Subramanian,Sharadha;Tamez,Victoriano;Tanner,Huw;Wan,Lifeng;Hu,Cheng;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Tellew,JohnE.;Huang,Shenlin;Yue,Qin;Chaudhary,Apurva;Tian,Hung;Iyer,Raman;Hassan,A.Quamrul;MathewsGriner,LesleyA.;LaBonte,LauraR.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Mishina,Yuji;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Sellers,WilliamR.;Lees,Emma;Shao,Wenlin;Dillon,MichaelP.;Stuart,DarrinD.[JournalofMedicinalChemistry,2020,vol.63,#5,p.2013-2027]

401816-16-8   
N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide 

[1]JournalofMedicinalChemistry,2019

[2]JournalofMedicinalChemistry,2019

[3]JournalofMedicinalChemistry,2019

[4]JournalofMedicinalChemistry,2019

[1]Ramurthy,Savithri;Taft,BenjaminR.;Aversa,RobertJ.;Barsanti,PaulA.;Burger,MatthewT.;Lou,Yan;Nishiguchi,GiseleA.;Rico,Alice;Setti,Lina;Smith,Aaron;Subramanian,Sharadha;Tamez,Victoriano;Tanner,Huw;Wan,Lifeng;Hu,Cheng;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Tellew,JohnE.;Huang,Shenlin;Yue,Qin;Chaudhary,Apurva;Tian,Hung;Iyer,Raman;Hassan,A.Quamrul;MathewsGriner,LesleyA.;LaBonte,LauraR.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Mishina,Yuji;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Sellers,WilliamR.;Lees,Emma;Shao,Wenlin;Dillon,MichaelP.;Stuart,DarrinD.[JournalofMedicinalChemistry,2020,vol.63,#5,p.2013-2027]

[2]Ramurthy,Savithri;Taft,BenjaminR.;Aversa,RobertJ.;Barsanti,PaulA.;Burger,MatthewT.;Lou,Yan;Nishiguchi,GiseleA.;Rico,Alice;Setti,Lina;Smith,Aaron;Subramanian,Sharadha;Tamez,Victoriano;Tanner,Huw;Wan,Lifeng;Hu,Cheng;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Tellew,JohnE.;Huang,Shenlin;Yue,Qin;Chaudhary,Apurva;Tian,Hung;Iyer,Raman;Hassan,A.Quamrul;MathewsGriner,LesleyA.;LaBonte,LauraR.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Mishina,Yuji;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Sellers,WilliamR.;Lees,Emma;Shao,Wenlin;Dillon,MichaelP.;Stuart,DarrinD.[JournalofMedicinalChemistry,2020,vol.63,#5,p.2013-2027]

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