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Home Amines 1802929-43-6
1802929-43-6,MFCD31560471
Catalog No.:AA01DGY0

1802929-43-6 | 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$100.00   $70.00
- +
5mg
≥98%
in stock  
$368.00   $257.00
- +
10mg
≥98%
in stock  
$586.00   $410.00
- +
25mg
≥98%
in stock  
$1,093.00   $765.00
- +
50mg
98%
in stock  
$1,913.00   $1,339.00
- +
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  • Technical Information
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Technical Information
Catalog Number:
AA01DGY0
Chemical Name:
8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS Number:
1802929-43-6
Molecular Formula:
C26H30Cl2N6O4
Molecular Weight:
561.4602
MDL Number:
MFCD31560471
SMILES:
C=CC(=O)N1CCN(CC1)CCCn1c2nc(NC)ncc2cc(c1=O)c1c(Cl)c(OC)cc(c1Cl)OC
Properties
Computed Properties
 
Complexity:
870  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
3.5  

Literature

Title: Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

Journal: Journal of medicinal chemistry 20170810

Title: Brameld KA, et al. Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido,3-dpyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors. J Med Chem. 2017 Aug 10;60(15):6516-6527.

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Tags:1802929-43-6 Molecular Formula|1802929-43-6 MDL|1802929-43-6 SMILES|1802929-43-6 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one