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1808255-64-2
Catalog No.:AA01EOQO

1808255-64-2 | 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$43.00   $30.00
- +
5mg
≥98%
in stock  
$162.00   $113.00
- +
10mg
≥98%
in stock  
$242.00   $169.00
- +
50mg
≥98%
in stock  
$798.00   $558.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EOQO
Chemical Name:
2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
CAS Number:
1808255-64-2
Molecular Formula:
C28H43Cl3N6O3
Molecular Weight:
618.0384
SMILES:
COc1cc2nc(nc(c2cc1OC)NC1CCN(CC1)Cc1ccccc1)N1CCCN(CC1)C.O.Cl.Cl.Cl
Properties
Computed Properties
 
Complexity:
656  
Covalently-Bonded Unit Count:
5  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment.

Journal: PloS one 20140101

Title: Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.

Journal: Cell death & disease 20130201

Title: Abnormal histone H3K9 dimethylation but normal dimethyltransferase EHMT2 expression in cloned sheep embryos.

Journal: Theriogenology 20121201

Title: Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20121009

Title: Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients.

Journal: AIDS (London, England) 20120731

Title: Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.

Journal: The Journal of antibiotics 20120501

Title: G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120418

Title: Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.

Journal: Analytical biochemistry 20120401

Title: An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases.

Journal: Journal of molecular biology 20120224

Title: IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo.

Journal: Reproduction, fertility, and development 20120101

Title: The effect of epigenetic factors on differentiation of pancreatic progenitor cells into insulin-producing cells.

Journal: Transplantation proceedings 20111101

Title: Epigenetic regulation of HIV-1 transcription.

Journal: Epigenomics 20110801

Title: Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.

Journal: Journal of molecular biology 20100702

Title: Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.

Journal: The Journal of biological chemistry 20100528

Title: A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.

Journal: Molecular bioSystems 20100510

Title: Chromatin flow cytometry identifies changes in epigenetic cell states.

Journal: Cells, tissues, organs 20100101

Title: Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

Journal: Nature structural & molecular biology 20090301

Title: Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

Journal: Cell stem cell 20081106

Title: Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

Journal: Molecular cell 20070209

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SDS
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Tags:1808255-64-2 Molecular Formula|1808255-64-2 MDL|1808255-64-2 SMILES|1808255-64-2 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
Catalog No.: AA01EOQO
1808255-64-2
1808255-64-2 | 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
Pack Size： 1mg
Purity： ≥98%
in stock
$43.00 $30.00
Pack Size： 5mg
Purity： ≥98%
in stock
$162.00 $113.00
Pack Size： 10mg
Purity： ≥98%
in stock
$242.00 $169.00
Pack Size： 50mg
Purity： ≥98%
in stock
$798.00 $558.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01EOQO
Chemical Name: 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine,trihydrochloride,hydrate
CAS Number: 1808255-64-2
Molecular Formula: C28H43Cl3N6O3
Molecular Weight: 618.0384
SMILES: COc1cc2nc(nc(c2cc1OC)NC1CCN(CC1)Cc1ccccc1)N1CCCN(CC1)C.O.Cl.Cl.Cl
Properties
Complexity: 656  
Covalently-Bonded Unit Count: 5  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 40  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 5  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment.

Journal: PloS one20140101

Title: Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.

Journal: Cell death & disease20130201

Title: Abnormal histone H3K9 dimethylation but normal dimethyltransferase EHMT2 expression in cloned sheep embryos.

Journal: Theriogenology20121201

Title: Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.

Journal: Proceedings of the National Academy of Sciences of the United States of America20121009

Title: Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients.

Journal: AIDS (London, England)20120731

Title: Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.

Journal: The Journal of antibiotics20120501

Title: G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20120418

Title: Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.

Journal: Analytical biochemistry20120401

Title: An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases.

Journal: Journal of molecular biology20120224

Title: IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo.

Journal: Reproduction, fertility, and development20120101

Title: The effect of epigenetic factors on differentiation of pancreatic progenitor cells into insulin-producing cells.

Journal: Transplantation proceedings20111101

Title: Epigenetic regulation of HIV-1 transcription.

Journal: Epigenomics20110801

Title: Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.

Journal: Journal of molecular biology20100702

Title: Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.

Journal: The Journal of biological chemistry20100528

Title: A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.

Journal: Molecular bioSystems20100510

Title: Chromatin flow cytometry identifies changes in epigenetic cell states.

Journal: Cells, tissues, organs20100101

Title: Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

Journal: Nature structural & molecular biology20090301

Title: Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

Journal: Cell stem cell20081106

Title: Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

Journal: Molecular cell20070209

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