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181183-52-8,MFCD08067740
Catalog No.:AA0022NP

181183-52-8 | Almotriptan malate

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25mg
>98.0%(HPLC)
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0022NP
Chemical Name:
Almotriptan malate
CAS Number:
181183-52-8
Molecular Formula:
C21H31N3O7S
Molecular Weight:
469.5517
MDL Number:
MFCD08067740
SMILES:
OC(=O)CC(C(=O)O)O.CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C
Properties
Computed Properties
 
Complexity:
612  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Treatment of perimenstrual migraine with triptans: an update.

Journal: Current pain and headache reports 20121001

Title: Frovatriptan versus almotriptan for acute treatment of menstrual migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study.

Journal: The journal of headache and pain 20120701

Title: Stability, responsiveness, and reproducibility of a visual analog scale for treatment satisfaction in migraine.

Journal: Headache 20120601

Title: Cost-effectiveness analysis of early versus non-early intervention in acute migraine based on evidence from the 'Act when Mild' study.

Journal: Applied health economics and health policy 20120501

Title: Oral sumatriptan and almotriptan--delimiting the MAOI effect.

Journal: Headache 20120501

Title: LC-ESI-MS/MS determination of in vivo metabolites of almotriptan in rat plasma, urine and feces: application to pharmacokinetics.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120401

Title: The impact of allodynia on the efficacy of almotriptan when given early in migraine: data from the 'Act when mild' study.

Journal: The International journal of neuroscience 20111201

Title: Effect of iontophoresis on in vitro transdermal absorption of almotriptan.

Journal: International journal of pharmaceutics 20110915

Title: Almotriptan for menstrually related migraine.

Journal: Expert opinion on pharmacotherapy 20110801

Title: A double-blind, randomized, multicenter, Italian study of frovatriptan versus almotriptan for the acute treatment of migraine.

Journal: The journal of headache and pain 20110601

Title: Improved patient satisfaction and pain evolution with almotriptan in migraine: a primary care study.

Journal: Current medical research and opinion 20110301

Title: Almotriptan 12.5 mg in menstrually related migraine: a randomized, double-blind, placebo-controlled study.

Journal: Cephalalgia : an international journal of headache 20110101

Title: Almotriptan for the acute treatment of adolescent migraine.

Journal: Expert opinion on pharmacotherapy 20101001

Title: Almotriptan: a review of 10 years' clinical experience.

Journal: Expert review of neurotherapeutics 20101001

Title: Almotriptan efficacy in migraine with allodynia: a rebuttal to Burstein and Jakubowski's critique of Schoenen et al.

Journal: Cephalalgia : an international journal of headache 20100901

Title: Influence of trigger factors on the efficacy of almotriptan as early intervention for the treatment of acute migraine in a primary care setting: the START study.

Journal: Expert review of neurotherapeutics 20100901

Title: Evolution of migraine-associated symptoms in menstrually related migraine following symptomatic treatment with almotriptan.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20100601

Title: Efficacy of almotriptan in early intervention for treatment of acute migraine in a primary care setting: the START study.

Journal: International journal of clinical practice 20100601

Title: Long-term, open-label safety study of oral almotriptan 12.5 mg for the acute treatment of migraine in adolescents.

Journal: Headache 20100501

Title: Drug dependence associated with triptans and ergot derivatives: a case/non-case study.

Journal: European journal of clinical pharmacology 20100401

Title: Almotriptan for the treatment of acute migraine: a review of early intervention trials.

Journal: Expert review of neurotherapeutics 20100301

Title: [Acute migraine: a treatment reserved for adults now recommended for adolescents].

Journal: Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec 20100101

Title: Almotriptan efficacy in migraine with allodynia: a critique of Schoenen et al.

Journal: Cephalalgia : an international journal of headache 20091001

Title: Variation in almotriptan effectiveness according to different prophylactic treatments.

Journal: Headache 20091001

Title: Migraine treatment with rizatriptan and almotriptan: a crossover study.

Journal: Headache 20090501

Title: [Almotriptan vs. ergotamine plus caffeine for acute migraine treatment. A cost-efficacy analysis].

Journal: Neurologia (Barcelona, Spain) 20090401

Title: Allodynia-associated symptoms, pain intensity and time to treatment: predicting treatment response in acute migraine intervention.

Journal: Headache 20090301

Title: Almotriptan efficacy in migraine with developing allodynia is as high as the efficacy in migraine without allodynia--but is it the same in migraine with established allodynia?

Journal: Headache 20090301

Title: Efficacy and tolerability of almotriptan in adolescents: a randomized, double-blind, placebo-controlled trial.

Journal: Headache 20081001

Title: Almotriptan and its combination with aceclofenac for migraine attacks: a study of efficacy and the influence of auto-evaluated brush allodynia.

Journal: Cephalalgia : an international journal of headache 20081001

Title: Seizure after use of almotriptan.

Journal: Clinical neurology and neurosurgery 20080901

Title: Almotriptan in triptan-naïve patients: new evidence of benefits.

Journal: Cephalalgia : an international journal of headache 20080901

Title: The 'Act when Mild' (AwM) study: a step forward in our understanding of early treatment in acute migraine.

Journal: Cephalalgia : an international journal of headache 20080901

Title: Applying the benefits of the AwM study in the clinic.

Journal: Cephalalgia : an international journal of headache 20080901

Title: Early vs. non-early intervention in acute migraine-'Act when Mild (AwM)'. A double-blind, placebo-controlled trial of almotriptan.

Journal: Cephalalgia : an international journal of headache 20080401

Title: A validated reversed phase HPLC method for the determination of process-related impurities in almotriptan malate API.

Journal: Journal of pharmaceutical and biomedical analysis 20080313

Title: Migraine-like headache in intracranial haemorrhage is alleviated by sumatriptan and almotriptan.

Journal: Cephalalgia : an international journal of headache 20080301

Title: Effect of early intervention with almotriptan vs placebo on migraine-associated functional disability: results from the AEGIS Trial.

Journal: Headache 20080301

Title: Characteristics of migraine attacks and responses to almotriptan treatment: a comparison of menstrually related and nonmenstrually related migraines.

Journal: Headache 20080201

Title: Almotriptan, an antimigraine agent, and its malate salt.

Journal: Acta crystallographica. Section C, Crystal structure communications 20080101

Title: Almotriptan: meeting today's needs in acute migraine treatment.

Journal: Expert review of neurotherapeutics 20071201

Title: Use of almotriptan in triptan-experienced and triptan-naïve patients.

Journal: Current medical research and opinion 20071001

Title: Meta-analysis examining the efficacy and safety of almotriptan in the acute treatment of migraine.

Journal: Headache 20070901

Title: Do 5HT1B/1D receptor agonists have an effect on mood and anxiety disorders?

Journal: Cephalalgia : an international journal of headache 20070501

Title: Effect of pain intensity and time to administration on responsiveness to almotriptan: results from AXERT 12.5 mg Time Versus Intensity Migraine Study (AIMS).

Journal: Headache 20070401

Title: Crossover, double-blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy.

Journal: European journal of neurology 20070301

Title: Early intervention with almotriptan: results of the AEGIS trial (AXERT Early Migraine Intervention Study).

Journal: Headache 20070201

Title: Patient preference in migraine therapy. A randomized, open-label, crossover clinical trial of acute treatment of migraine with oral almotriptan and rizatriptan.

Journal: Journal of neurology 20070201

Title: Almotriptan and zolmitriptan in the acute treatment of migraine.

Journal: Acta neurologica Scandinavica 20070101

Title: A pharmacoeconomic evaluation of oral triptans in the treatment of migraine in Italy.

Journal: Minerva medica 20061201

Title: Disposition and metabolism of almotriptan in rats, dogs and monkeys.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20060901

Title: Ethanol does not significantly affect the bioavailability of almotriptan: an open, randomized, crossover, single-dose, phase I clinical trial in healthy volunteers.

Journal: International journal of clinical pharmacology and therapeutics 20060901

Title: Efficacy and tolerability of almotriptan versus zolmitriptan for the acute treatment of menstrual migraine.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20060501

Title: Efficacy, speed of action and tolerability of almotriptan in the acute treatment of migraine: pooled individual patient data from four randomized, double-blind, placebo-controlled clinical trials.

Journal: Cephalalgia : an international journal of headache 20060401

Title: Effect of food intake on the bioavailability of almotriptan, an antimigraine compound, in healthy volunteers: an open, randomized, crossover, single-dose clinical trial.

Journal: International journal of clinical pharmacology and therapeutics 20060401

Title: Almotriptan in the acute treatment of migraine in patients 11-17 years old: an open-label pilot study of efficacy and safety.

Journal: The journal of headache and pain 20060401

Title: [Economic evaluation of acute migraine attack treatment with triptans in Spain].

Journal: Neurologia (Barcelona, Spain) 20060301

Title: Value of postmarketing surveillance studies in achieving a complete picture of antimigraine agents: using almotriptan as an example.

Journal: The journal of headache and pain 20060201

Title: Evaluation of efficacy, tolerability, and treatment satisfaction with almotriptan in 3 consecutive migraine attacks. The migraine--satisfaction with treatment: reality with Almogran study.

Journal: European neurology 20060101

Title: Focus on trial endpoints of clinical relevance and the use of almotriptan for the acute treatment of migraine.

Journal: International journal of clinical practice 20051101

Title: Efficacy of almotriptan 12.5 mg in achieving migraine-related composite endpoints: a double-blind, randomized, placebo-controlled study in patients controlled study in patients with previous poor response to sumatriptan 50 mg.

Journal: Current medical research and opinion 20051001

Title: Multiple attack study on the available triptans in Italy versus placebo.

Journal: European journal of neurology 20050701

Title: Consistent efficacy, tolerability, and high levels of satisfaction with almotriptan 12.5 mg when used to treat multiple migraine attacks in routine clinical practice.

Journal: Headache 20050601

Title: Effects of symptomatic treatments on cutaneous hyperalgesia and laser evoked potentials during migraine attack.

Journal: Cephalalgia : an international journal of headache 20050501

Title: Early triptan intervention in migraine: an overview.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20050501

Title: Correlation between lipophilicity and triptan outcomes.

Journal: Headache 20050101

Title: [Tolerance to almotriptan and its effectiveness in primary care].

Journal: Atencion primaria 20050101

Title: Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine.

Journal: Clinical pharmacokinetics 20050101

Title: Efficacy and tolerability of almotriptan in controlled clinical trials.

Journal: European neurology 20050101

Title: Efficacy and tolerability of almotriptan in postmarketing surveillance studies.

Journal: European neurology 20050101

Title: Almotriptan in migraine patients who respond poorly to oral sumatriptan: a double-blind, randomized trial.

Journal: European neurology 20050101

Title: Almotriptan in migraine patients who respond poorly to oral sumatriptan: a double-blind, randomized trial.

Journal: Headache 20050101

Title: Pharmacokinetics and safety of oral almotriptan in healthy male volunteers.

Journal: Biopharmaceutics & drug disposition 20041001

Title: Evaluating triptan usage: a rebuttal.

Journal: Headache 20041001

Title: TRIPSTAR: prioritizing oral triptan treatment attributes in migraine management.

Journal: Acta neurologica Scandinavica 20040901

Title: [Meta-analysis of triptan treatment in migraine].

Journal: No to shinkei = Brain and nerve 20040901

Title: Meta-analysis of oral triptans.

Journal: Cephalalgia : an international journal of headache 20040801

Title: Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040701

Title: [Almotriptan. One more triptan for migraines].

Journal: Revue de l'infirmiere 20040601

Title: Oral almotriptan: practical uses in the acute treatment of migraine.

Journal: Expert review of neurotherapeutics 20040501

Title: A comparison of the pharmacokinetics and tolerability of the anti-migraine compound almotriptan in healthy adolescents and adults.

Journal: Cephalalgia : an international journal of headache 20040401

Title: Almotriptan improves response rates when treatment is within 1 hour of migraine onset.

Journal: Headache 20040401

Title: Evaluating triptan usage.

Journal: Headache 20040201

Title: A comparison of the cost-effectiveness of almotriptan and sumatriptan in the treatment of acute migraine using a composite efficacy/tolerability end point.

Journal: Journal of managed care pharmacy : JMCP 20040101

Title: Migraine pathophysiology and its clinical implications.

Journal: Cephalalgia : an international journal of headache 20040101

Title: What do patients want from acute migraine treatment?

Journal: Cephalalgia : an international journal of headache 20040101

Title: Clinical profile and practice experience of almotriptan.

Journal: Cephalalgia : an international journal of headache 20040101

Title: Clinical benefits of early triptan therapy for migraine.

Journal: Cephalalgia : an international journal of headache 20040101

Title: Cost-effectiveness of almotriptan and rizatriptan in the treatment of acute migraine.

Journal: Clinical therapeutics 20031101

Title: A review of the clinical efficacy and tolerability of almotriptan in acute migraine.

Journal: Expert opinion on pharmacotherapy 20030701

Title: Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401

Title: Interaction between ketoconazole and almotriptan in healthy volunteers.

Journal: Journal of clinical pharmacology 20030401

Title: A case of carotidynia with response to almotriptan.

Journal: Cephalalgia : an international journal of headache 20030301

Title: A review of the effects of almotriptan and other triptans on clinical trial outcomes that are meaningful to patients with migraine.

Journal: Clinical therapeutics 20030201

Title: [Almotriptan in the treatment of migraine attacks in clinical practice: results of the TEA 2000 observational study].

Journal: Neurologia (Barcelona, Spain) 20030101

Title: Almotriptan versus rizatriptan in patients with migraine in Spain.

Journal: Headache 20030101

Title: Early intervention with almotriptan improves sustained pain-free response in acute migraine.

Journal: Headache 20030101

Title: Almotriptan: an effective and well-tolerated treatment for migraine pain.

Journal: Drugs of today (Barcelona, Spain : 1998) 20030101

Title: Absolute bioavailability, pharmacokinetics, and urinary excretion of the novel antimigraine agent almotriptan in healthy male volunteers.

Journal: Journal of clinical pharmacology 20021201

Title: Efficacy and safety of almotriptan malate for migraine.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20021115

Title: New medications show promise for migraine sufferers.

Journal: Dentistry today 20021001

Title: Mechanisms of action of the 5-HT1B/1D receptor agonists.

Journal: Archives of neurology 20020701

Title: Almotriptan is an effective and well-tolerated treatment for migraine pain: results of a randomized, double-blind, placebo-controlled clinical trial.

Journal: Cephalalgia : an international journal of headache 20020701

Title: New drugs 2002, part III.

Journal: Nursing 20020701

Title: Use of rescue medication in trials of almotriptan versus placebo in the treatment of acute migraine.

Journal: Clinical therapeutics 20020401

Title: Triptan medications to treat acute migraine.

Journal: Lancet (London, England) 20020330

Title: Triptan medications to treat acute migraine.

Journal: Lancet (London, England) 20020330

Title: Triptan medications to treat acute migraine.

Journal: Lancet (London, England) 20020330

Title: Cardiovascular effect of almotriptan in treated hypertensive patients.

Journal: Clinical pharmacology and therapeutics 20020301

Title: Almotriptan (Axert) and frovatriptan (Frova) for migrane.

Journal: The Medical letter on drugs and therapeutics 20020218

Title: Cost savings in migraine associated with less chest pain on new triptan therapy.

Journal: The American journal of managed care 20020201

Title: Almotriptan: a review of pharmacology, clinical efficacy, and tolerability.

Journal: The American journal of managed care 20020201

Title: Health outcomes evaluations: estimating the impact of almotriptan in managed care settings.

Journal: The American journal of managed care 20020201

Title: Almotriptan versus sumatriptan in migraine treatment: direct medical costs of managing adverse chest symptoms.

Journal: The American journal of managed care 20020201

Title: How does almotriptan compare with other triptans? A review of data from placebo-controlled clinical trials.

Journal: Headache 20020201

Title: [Treatment of migraine in patients with hypertension and ischemic heart disease].

Journal: Ideggyogyaszati szemle 20020120

Title: Almotriptan: a review of its use in migraine.

Journal: Drugs 20020101

Title: Almotriptan reduces the incidence of migraine-associated symptoms: a pooled analysis.

Journal: Headache 20020101

Title: Almotriptan increases pain-free status in patients with acute migraine treated in placebo-controlled clinical trials.

Journal: Headache 20020101

Title: Impact of chest pain on cost of migraine treatment with almotriptan and sumatriptan.

Journal: Headache 20020101

Title: Almotriptan increases sustained pain-free outcomes in acute migraine: results from three controlled clinical trials.

Journal: Headache 20020101

Title: Within-patient early versus delayed treatment of migraine attacks with almotriptan: the sooner the better.

Journal: Headache 20020101

Title: A long-term open-label study of oral almotriptan 12.5 mg for the treatment of acute migraine.

Journal: Headache 20020101

Title: Spotlight on almotriptan in migraine.

Journal: CNS drugs 20020101

Title: Almotriptan, a new anti-migraine agent: a review.

Journal: CNS drug reviews 20020101

Title: Dose finding, placebo-controlled study of oral almotriptan in the acute treatment of migraine.

Journal: Neurology 20011127

Title: Oral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials.

Journal: Lancet (London, England) 20011117

Title: Efficacy and tolerability of subcutaneous almotriptan for the treatment of acute migraine: a randomized, double-blind, parallel-group, dose-finding study.

Journal: Clinical therapeutics 20011101

Title: Vascular effects of the new anti-migraine agent almotriptan on human cranial and peripheral arteries.

Journal: Cephalalgia : an international journal of headache 20011001

Title: Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics.

Journal: Arzneimittel-Forschung 20010901

Title: [Migraine headache. Severe attacks: triptans are essential].

Journal: MMW Fortschritte der Medizin 20010719

Title: Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans).

Journal: Archives of neurology 20010701

Title: Oral almotriptan vs. oral sumatriptan in the abortive treatment of migraine: a double-blind, randomized, parallel-group, optimum-dose comparison.

Journal: Archives of neurology 20010601

Title: Oral almotriptan in the treatment of migraine: safety and tolerability.

Journal: Headache 20010501

Title: Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans.

Journal: British journal of clinical pharmacology 20010501

Title: [Current topics: expectation for new triptans].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20010410

Title: Hemodynamic and electrocardiographic effects of almotriptan in healthy volunteers.

Journal: Journal of cardiovascular pharmacology 20010301

Title: Acute treatment of migraine and the role of triptans.

Journal: Current neurology and neuroscience reports 20010301

Title: Evaluation of the potential pharmacokinetic interaction between almotriptan and fluoxetine in healthy volunteers.

Journal: Journal of clinical pharmacology 20010201

Title: Almotriptan: a balanced approach to migraine.

Journal: Hospital medicine (London, England : 1998) 20010201

Title: Lack of pharmacokinetic interaction between the antimigraine compound, almotriptan, and propranolol in healthy volunteers.

Journal: Cephalalgia : an international journal of headache 20010201

Title: Long-term efficacy and safety of oral almotriptan: interim analysis of a 1-year open study.

Journal: Headache 20010101

Title: Treatment satisfaction, functional status, and health-related quality of life of migraine patients treated with almotriptan or sumatriptan.

Journal: Clinical therapeutics 20010101

Title: Tolerability and efficacy of almotriptan in the long-term treatment of migraine.

Journal: European neurology 20010101

Title: Almotriptan: pharmacological differences and clinical results.

Journal: Current medical research and opinion 20010101

Title: Comparative aspects of triptans in treating migraine.

Journal: Clinical cornerstone 20010101

Title: Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine.

Journal: European journal of pharmacology 20001220

Title: Cardiovascular safety profile of almotriptan, a new indolic derivative for the treatment of migraine.

Journal: European journal of pharmacology 20001220

Title: Bou J , et al. Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur J Pharmacol, 2000. 410(1): p. 33-41.

Title: Gras J, et al. Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics. Arzneimittelforschung, 2001. 51(9): p. 726-32.

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Tags:181183-52-8 Molecular Formula|181183-52-8 MDL|181183-52-8 SMILES|181183-52-8 Almotriptan malate