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182431-12-5,MFCD16620494
Catalog No.:AA0023ST

182431-12-5 | Lomitapide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
25mg
>98.0%(HPLC)(qNMR)
in stock  
$128.00   $90.00
- +
100mg
>98.0%(HPLC)(qNMR)
in stock  
$346.00   $242.00
- +
1g
98%
in stock  
$2,013.00   $1,409.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0023ST
Chemical Name:
Lomitapide
CAS Number:
182431-12-5
Molecular Formula:
C39H37F6N3O2
Molecular Weight:
693.7204
MDL Number:
MFCD16620494
SMILES:
O=C(c1ccccc1c1ccc(cc1)C(F)(F)F)NC1CCN(CC1)CCCCC1(C(=O)NCC(F)(F)F)c2ccccc2c2c1cccc2
Properties
Computed Properties
 
Complexity:
1110  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
50  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
8.6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2016/55934,2016,A1Locationinpatent:Paragraph0129

[2]CurrentPatentAssignee:NANJINGHUAWEMEDICALTECHNOLOGYDEVELOPMENTCO.,LTD.-CN105523994,2016,ALocationinpatent:Paragraph0048;0049;0050

[3]CurrentPatentAssignee:NANJINGHUAWEMEDICALTECHNOLOGYDEVELOPMENTCO.,LTD.-CN105461618,2016,ALocationinpatent:Paragraph0051-0052

[4]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1Locationinpatent:Page/Pagecolumn19

[5]CurrentPatentAssignee:HETERODRUGSLIMITED-WO2016/71849,2016,A1Locationinpatent:Page/Pagecolumn21

[6]CurrentPatentAssignee:MSNLABORATORIESPRIVATELIMITED-WO2017/98522,2017,A1Locationinpatent:Page/Pagecolumn18;22;27;29

[7]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-US2016/83345,2016,A1Locationinpatent:Paragraph0195

[1]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[2]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[3]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[4]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[5]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[6]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[1]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[2]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[3]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[4]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[1]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[2]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[3]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

[4]CurrentPatentAssignee:VIATRISINC-WO2016/12934,2016,A1

Literature

Title: Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study.

Journal: Lancet (London, England) 20130105

Title: Multiple functions of microsomal triglyceride transfer protein.

Journal: Nutrition & metabolism 20120101

Title: Mipomersen: evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia.

Journal: Core evidence 20120101

Title: New clinical perspectives of hypolipidemic drug therapy in severe hypercholesterolemia.

Journal: Current medicinal chemistry 20120101

Title: Familial hypercholesterolemia: present and future management.

Journal: Current cardiology reports 20111201

Title: Lomitapide.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20111001

Title: Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats.

Journal: Clinical and experimental pharmacology & physiology 20110501

Title: Lomitapide, a microsomal triglyceride transfer protein inhibitor for the treatment of hypercholesterolemia.

Journal: IDrugs : the investigational drugs journal 20100201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090601

Title: Dyslipidemia and cardiovascular diseases.

Journal: Current opinion in lipidology 20090401

Title: Novel nonstatin strategies to lower low-density lipoprotein cholesterol.

Journal: Current atherosclerosis reports 20090101

Title: Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia.

Journal: Nature clinical practice. Cardiovascular medicine 20080801

Title: Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia.

Journal: The New England journal of medicine 20070111

Title: 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

Journal: Bioorganic & medicinal chemistry letters 20041018

Title: Atorvastatin increases hepatic fatty acid beta-oxidation in sucrose-fed rats: comparison with an MTP inhibitor.

Journal: European journal of pharmacology 20021129

Title: A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

Journal: Journal of medicinal chemistry 20010315

Title: Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70.

Title: Davis KA. et al. Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia. Am J Health Syst Pharm. 2014 Jun 15;71(12):1001-8.

Title: Dhote V, et al. Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats. Clin Exp Pharmacol Physiol. 2011 May;38(5):338-44.

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