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182563-08-2,MFCD19686973
Catalog No.:AA00AKON

182563-08-2 | Ly 334370

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$100.00   $70.00
- +
2mg
95%
1 week  
$115.00   $80.00
- +
5mg
95%
1 week  
$157.00   $110.00
- +
10mg
99%
1 week  
$168.00   $117.00
- +
25mg
95%
1 week  
$386.00   $270.00
- +
50mg
99%
1 week  
$598.00   $419.00
- +
100mg
95%
1 week  
$912.00   $639.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AKON
Chemical Name:
Ly 334370
CAS Number:
182563-08-2
Molecular Formula:
C21H22FN3O
Molecular Weight:
351.4173
MDL Number:
MFCD19686973
SMILES:
CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F
Properties
Computed Properties
 
Complexity:
486  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.6  

Literature

Title: 5-Hydroxyptryptamine 1F (5-HT1F) receptor agonism. A possible new treatment principle for acute migraine attacks.

Journal: Cephalalgia : an international journal of headache 20101001

Title: Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan.

Journal: Cephalalgia : an international journal of headache 20101001

Title: Acute treatment of migraine with the selective 5-HT1F receptor agonist lasmiditan--a randomised proof-of-concept trial.

Journal: Cephalalgia : an international journal of headache 20101001

Title: 5-HT(1F) Receptor agonists: a new treatment option for migraine attacks?

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20100401

Title: Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide.

Journal: Journal of medicinal chemistry 20080626

Title: [3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050301

Title: [3H]LY334370, a novel radioligand for the 5-HT1F receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050301

Title: Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists.

Journal: Bioorganic & medicinal chemistry letters 20041220

Title: Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists.

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.

Journal: Journal of medicinal chemistry 20030703

Title: Crystal forms of LY334370 HCl: isolation, solid-state characterization, and physicochemical properties.

Journal: Journal of pharmaceutical sciences 20030601

Title: Treatment of acute migraine.

Journal: Lancet (London, England) 20020302

Title: Selective seratonin 1F (5-HT(1F)) receptor agonist LY334370 for acute migraine: a randomised controlled trial.

Journal: Lancet (London, England) 20011013

Title: The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs.

Journal: British journal of pharmacology 20010801

Title: Shepheard S, et al. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370. Cephalalgia. 1999 Dec;19(10):851-8.

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