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18417-89-5,MFCD00866463
Catalog No.:AA00AOY4

18417-89-5 | SANGIVAMYCIN

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1mg
97%
1 week  
$304.00   $213.00
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5mg
97%
1 week  
$717.00   $502.00
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10mg
97%
1 week  
$1,066.00   $747.00
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25mg
97%
1 week  
$2,082.00   $1,458.00
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50mg
97%
1 week  
$3,384.00   $2,369.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AOY4
Chemical Name:
SANGIVAMYCIN
CAS Number:
18417-89-5
Molecular Formula:
C12H15N5O5
Molecular Weight:
309.2780
MDL Number:
MFCD00866463
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2N)C(=O)N
Properties
Computed Properties
 
Complexity:
440  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
3  
XLogP3:
-2.5  

Downstream Synthesis Route

[1]Heterocycles,1992,vol.33,p.391-404

Literature

Title: Molecular basis for activation of G protein-coupled receptor kinases.

Journal: The EMBO journal 20101006

Title: Cell cycle arrest and cytochrome c-mediated apoptotic induction in human lung cancer A549 cells by MCS-C2, an analogue of sangivamycin.

Journal: Journal of microbiology and biotechnology 20100201

Title: The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers.

Journal: Cell cycle (Georgetown, Tex.) 20090501

Title: ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.

Journal: BMC cancer 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Deciphering deazapurine biosynthesis: pathway for pyrrolopyrimidine nucleosides toyocamycin and sangivamycin.

Journal: Chemistry & biology 20080825

Title: A CoMSIA study on the adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues.

Journal: Bioorganic & medicinal chemistry 20080501

Title: Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin.

Journal: Japanese journal of clinical oncology 20071101

Title: The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation.

Journal: The Journal of biological chemistry 20070518

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20050201

Title: A TOPS-MODE approach to predict adenosine kinase inhibition.

Journal: Bioorganic & medicinal chemistry letters 20040621

Title: Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors.

Journal: Brain research 20021220

Title: Phorbol myristate acetate induces ruffling of the acrosome of human sperm.

Journal: Fertility and sterility 20020701

Title: QSAR study on adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues using the hansch approach.

Journal: Bioorganic & medicinal chemistry letters 20020325

Title: Selective growth inhibition by sangivamycin of human umbilical vein endothelial cells.

Journal: International journal of oncology 20010501

Title: Synthesis of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides. Isosteres of sangivamycin, tubercidin, and toyocamycin.

Journal: Carbohydrate research 20010309

Title: Synthesis of carbocyclic analogs of 2',3'-dideoxysangivamycin, 2',3'-dideoxytoyocamycin, and 2',3'-dideoxytriciribine.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: the effect of certain 4- and 4,6-substituents on the antiviral activity of pyrrolo[2,3-d]pyrimidines.

Journal: Journal of medicinal chemistry 19960830

Title: Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and ++thiosangivamycin: influence of various 7-substituents on antiviral activity.

Journal: Journal of medicinal chemistry 19960216

Title: Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.

Journal: Journal of medicinal chemistry 19950929

Title: Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents.

Journal: Farmaco (Societa chimica italiana : 1989) 19910101

Title: Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections.

Journal: Journal of medicinal chemistry 19901201

Title: Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy)methyl]pyrazolo[3,4-d]pyrimidine analogues of sangivamycin and toyocamycin.

Journal: Journal of medicinal chemistry 19900701

Title: Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives.

Journal: Antimicrobial agents and chemotherapy 19890801

Title: Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin.

Journal: Journal of medicinal chemistry 19890701

Title: Antiviral activities of 2'-deoxyribofuranosyl and arabinofuranosyl analogs of sangivamycin against retro- and DNA viruses.

Journal: Antiviral research 19881211

Title: Pyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirus.

Journal: Antimicrobial agents and chemotherapy 19870401

Title: Nucleic acid related compounds. 51. Synthesis and biological properties of sugar-modified analogues of the nucleoside antibiotics tubercidin, toyocamycin, sangivamycin, and formycin.

Journal: Journal of medicinal chemistry 19870301

Title: Xylotubercidin against herpes simplex virus type 2 in mice.

Journal: Antimicrobial agents and chemotherapy 19861101

Title: Antiviral activity of C-5 substituted tubercidin analogues.

Journal: Journal of medicinal chemistry 19840301

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