Home Amines 184475-55-6
184475-55-6,MFCD00952718
Catalog No.:AA01DPWE

184475-55-6 | 4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-,monohydrochloride

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Purity
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25mg
98%(HPLC)
in stock  
$34.00   $24.00
- +
100mg
98%(HPLC)
in stock  
$99.00   $69.00
- +
250mg
95%
in stock  
$145.00   $102.00
- +
1g
98%(HPLC)
in stock  
$148.00   $104.00
- +
5g
98%(HPLC)
in stock  
$296.00   $207.00
- +
10g
98%(HPLC)
in stock  
$491.00   $344.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01DPWE
Chemical Name:
4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-,monohydrochloride
CAS Number:
184475-55-6
Molecular Formula:
C22H25Cl2FN4O3
Molecular Weight:
483.3633
MDL Number:
MFCD00952718
SMILES:
COc1cc2ncnc(c2cc1OCCCN1CCOCC1)Nc1ccc(c(c1)Cl)F.Cl
Properties
Computed Properties
 
Complexity:
545  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  

Downstream Synthesis Route
184475-55-6    577-11-7   
gefitinibdocusate 

[1]MolecularPharmaceutics,2018,vol.15,p.5678-5696

Literature

Title: Wakeling AE, et al. ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

Title: Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.

Title: Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8.

Title: Morgillo F, et al. Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines. Clin Cancer Res. 2013 Jul 1;19(13):3508-19.

Title: Miyake K, et al. Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats. J Med Invest. 2012;59(1-2):174-85.

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SDS
Tags:184475-55-6 Molecular Formula|184475-55-6 MDL|184475-55-6 SMILES|184475-55-6 4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-,monohydrochloride