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Home Other Building Blocks 1849590-01-7
1849590-01-7,MFCD30489732
Catalog No.:AA00ABOO

1849590-01-7 | eFT508

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$37.00   $26.00
- +
100mg
98%
in stock  
$510.00   $357.00
- +
250mg
98%
in stock  
$843.00   $590.00
- +
1g
98%
in stock  
$2,505.00   $1,754.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABOO
Chemical Name:
eFT508
CAS Number:
1849590-01-7
Molecular Formula:
C17H20N6O2
Molecular Weight:
340.3797
MDL Number:
MFCD30489732
SMILES:
Nc1ncnc(c1)Nc1cc(C)c2n(c1=O)C1(CCCCC1)NC2=O
Properties
Computed Properties
 
Complexity:
664  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
1.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:EFFECTORTHERAPEUTICSINC-US2020/131179,2020,A1

CASUnavailable 
  1849590-01-7 

[1]CurrentPatentAssignee:EFFECTORTHERAPEUTICSINC-US2020/131179,2020,A1

[1]CurrentPatentAssignee:EFFECTORTHERAPEUTICSINC-US2020/131179,2020,A1Locationinpatent:Paragraph0095;0099-0100

[1]CurrentPatentAssignee:WUHANJIUZHOUYUMINPHARMACEUTICALTECH-CN114736205,2022,ALocationinpatent:Paragraph0052;0083-0089

[1]CurrentPatentAssignee:WUHANJIUZHOUYUMINPHARMACEUTICALTECH-CN114736205,2022,A

Literature

Title: Kevin R. Webster, et al. eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL). Blood 2015 126:1554.

Title: Xu Y, et al. Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nat Med. 2019 Feb;25(2):301-311.

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SDS
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