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185222-90-6,MFCD05861376
Catalog No.:AA00AL26

185222-90-6 | MRS-1191

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5mg
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10mg
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$534.00   $374.00
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25mg
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$1,059.00   $741.00
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50mg
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100mg
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$2,998.00   $2,099.00
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500mg
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1000mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AL26
Chemical Name:
MRS-1191
CAS Number:
185222-90-6
Molecular Formula:
C31H27NO4
Molecular Weight:
477.5504
MDL Number:
MFCD05861376
SMILES:
CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1
NSC Number:
695673
Properties
Computed Properties
 
Complexity:
915  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  
XLogP3:
6.1  

Literature

Title: Resveratrol 3-O-D-glucuronide and resveratrol 4'-O-D-glucuronide inhibit colon cancer cell growth: evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest.

Journal: Molecular nutrition & food research 20131001

Title: A3 adenosine receptor-mediated p53-dependent apoptosis in Lu-65 human lung cancer cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation.

Journal: Shock (Augusta, Ga.) 20110201

Title: Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20100501

Title: The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells.

Journal: Neurochemistry international 20100101

Title: Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091201

Title: Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20091115

Title: Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.

Journal: Journal of cardiovascular pharmacology 20090501

Title: Dual purinergic synaptic transmission in the human enteric nervous system.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080201

Title: Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: Barrier qualities of the mouse eye to topically applied drugs.

Journal: Experimental eye research 20070701

Title: Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.

Journal: European journal of pharmacology 20060701

Title: Adenosine A(3) receptor mediated coronary vasodilation in the rat heart: changes that occur with maturation.

Journal: Mechanisms of ageing and development 20060301

Title: Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.

Journal: European journal of pharmacology 20060113

Title: Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation.

Journal: Anticancer research 20060101

Title: Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons.

Journal: Neurochemistry international 20051001

Title: Inosine, calcium channels, and neuroprotection against ischemic brain injury.

Journal: Stroke 20050901

Title: The cross-species A3 adenosine-receptor antagonist MRS 1292 inhibits adenosine-triggered human nonpigmented ciliary epithelial cell fluid release and reduces mouse intraocular pressure.

Journal: Current eye research 20050901

Title: Resveratrol-mediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits.

Journal: Experimental eye research 20050401

Title: Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation.

Journal: American journal of physiology. Heart and circulatory physiology 20050101

Title: Activation of A3 adenosine receptors attenuates lung injury after in vivo reperfusion.

Journal: Anesthesiology 20041101

Title: The role of intraspinal adenosine A1 receptors in sympathetic regulation.

Journal: European journal of pharmacology 20040510

Title: Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner.

Journal: The European journal of neuroscience 20040501

Title: Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse.

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: Knockout of A3 adenosine receptors reduces mouse intraocular pressure.

Journal: Investigative ophthalmology & visual science 20020901

Title: Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells.

Journal: International journal of cancer 20020520

Title: Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.

Journal: British journal of pharmacology 20010901

Title: Role of adenosine in ischemic preconditioning in rats depends critically on the duration of the stimulus and involves both A(1) and A(3) receptors.

Journal: Cardiovascular research 20010901

Title: A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse.

Journal: British journal of pharmacology 20010901

Title: Adenosine-enhanced ischemic preconditioning: adenosine receptor involvement during ischemia and reperfusion.

Journal: American journal of physiology. Heart and circulatory physiology 20010201

Title: Activation of the A3 adenosine receptor affects cell cycle progression and cell growth.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20000301

Title: Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 19980813

Title: Pharmacological characterization of novel A3 adenosine receptor-selective antagonists.

Journal: Neuropharmacology 19970901

Title: 6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 19961108

Title: Jacobson KA, et al. Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacology. 1997 Sep;36(9):1157-65.

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Tags:185222-90-6 Molecular Formula|185222-90-6 MDL|185222-90-6 SMILES|185222-90-6 MRS-1191