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1858276-04-6,MFCD32062692
Catalog No.:AA01KILM

1858276-04-6 | [(1R,2S,4R)-4-[[5-[[4-((1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthien-2-yl]carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$98.00   $68.00
- +
5mg
≥98%
in stock  
$432.00   $302.00
- +
10mg
98%
in stock  
$644.00   $451.00
- +
25mg
≥98%
in stock  
$1,195.00   $836.00
- +
50mg
98%
in stock  
$1,398.00   $979.00
- +
100mg
98%
in stock  
$2,271.00   $1,590.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01KILM
Chemical Name:
[(1R,2S,4R)-4-[[5-[[4-((1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthien-2-yl]carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate
CAS Number:
1858276-04-6
Molecular Formula:
C25H28ClN5O5S2
Molecular Weight:
578.1033
MDL Number:
MFCD32062692
SMILES:
O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=C(C(C3=C[C@@]([C@@H]4NCCC5=C4C=C(Cl)C=C5)=C(C)S3)=O)C=NC=N2)C1)(N)=O
Properties

Downstream Synthesis Route

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[3]Langston,StevenP.;Grossman,Stephen;England,Dylan;Afroze,Roushan;Bence,Neil;Bowman,Douglas;Bump,Nancy;Chau,Ryan;Chuang,Bei-Ching;Claiborne,Christopher;Cohen,Larry;Connolly,Kelly;Duffey,Matthew;Durvasula,Nitya;Freeze,Scott;Gallery,Melissa;Galvin,Katherine;Gaulin,Jeffrey;Gershman,Rachel;Greenspan,Paul;Grieves,Jessica;Guo,Jianping;Gulavita,Nanda;Hailu,Shumet;He,Xingyue;Hoar,Kara;Hu,Yongbo;Hu,Zhigen;Ito,Mitsuhiro;Kim,Mi-Sook;Lane,ScottWeston;Lok,David;Lublinsky,Anya;Mallender,William;McIntyre,Charles;Minissale,James;Mizutani,Hirotake;Mizutani,Miho;Molchinova,Nina;Ono,Koji;Patil,Ashok;Qian,Mark;Riceberg,Jessica;Shindi,Vaishali;Sintchak,MichaelD.;Song,Keli;Soucy,Teresa;Wang,Yana;Xu,He;Yang,Xiaofeng;Zawadzka,Agatha;Zhang,Ji;Pulukuri,SaiM.[JournalofMedicinalChemistry,2021,vol.64,#5,p.2501-2520]

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[3]Langston,StevenP.;Grossman,Stephen;England,Dylan;Afroze,Roushan;Bence,Neil;Bowman,Douglas;Bump,Nancy;Chau,Ryan;Chuang,Bei-Ching;Claiborne,Christopher;Cohen,Larry;Connolly,Kelly;Duffey,Matthew;Durvasula,Nitya;Freeze,Scott;Gallery,Melissa;Galvin,Katherine;Gaulin,Jeffrey;Gershman,Rachel;Greenspan,Paul;Grieves,Jessica;Guo,Jianping;Gulavita,Nanda;Hailu,Shumet;He,Xingyue;Hoar,Kara;Hu,Yongbo;Hu,Zhigen;Ito,Mitsuhiro;Kim,Mi-Sook;Lane,ScottWeston;Lok,David;Lublinsky,Anya;Mallender,William;McIntyre,Charles;Minissale,James;Mizutani,Hirotake;Mizutani,Miho;Molchinova,Nina;Ono,Koji;Patil,Ashok;Qian,Mark;Riceberg,Jessica;Shindi,Vaishali;Sintchak,MichaelD.;Song,Keli;Soucy,Teresa;Wang,Yana;Xu,He;Yang,Xiaofeng;Zawadzka,Agatha;Zhang,Ji;Pulukuri,SaiM.[JournalofMedicinalChemistry,2021,vol.64,#5,p.2501-2520]

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[3]Langston,StevenP.;Grossman,Stephen;England,Dylan;Afroze,Roushan;Bence,Neil;Bowman,Douglas;Bump,Nancy;Chau,Ryan;Chuang,Bei-Ching;Claiborne,Christopher;Cohen,Larry;Connolly,Kelly;Duffey,Matthew;Durvasula,Nitya;Freeze,Scott;Gallery,Melissa;Galvin,Katherine;Gaulin,Jeffrey;Gershman,Rachel;Greenspan,Paul;Grieves,Jessica;Guo,Jianping;Gulavita,Nanda;Hailu,Shumet;He,Xingyue;Hoar,Kara;Hu,Yongbo;Hu,Zhigen;Ito,Mitsuhiro;Kim,Mi-Sook;Lane,ScottWeston;Lok,David;Lublinsky,Anya;Mallender,William;McIntyre,Charles;Minissale,James;Mizutani,Hirotake;Mizutani,Miho;Molchinova,Nina;Ono,Koji;Patil,Ashok;Qian,Mark;Riceberg,Jessica;Shindi,Vaishali;Sintchak,MichaelD.;Song,Keli;Soucy,Teresa;Wang,Yana;Xu,He;Yang,Xiaofeng;Zawadzka,Agatha;Zhang,Ji;Pulukuri,SaiM.[JournalofMedicinalChemistry,2021,vol.64,#5,p.2501-2520]

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[3]Langston,StevenP.;Grossman,Stephen;England,Dylan;Afroze,Roushan;Bence,Neil;Bowman,Douglas;Bump,Nancy;Chau,Ryan;Chuang,Bei-Ching;Claiborne,Christopher;Cohen,Larry;Connolly,Kelly;Duffey,Matthew;Durvasula,Nitya;Freeze,Scott;Gallery,Melissa;Galvin,Katherine;Gaulin,Jeffrey;Gershman,Rachel;Greenspan,Paul;Grieves,Jessica;Guo,Jianping;Gulavita,Nanda;Hailu,Shumet;He,Xingyue;Hoar,Kara;Hu,Yongbo;Hu,Zhigen;Ito,Mitsuhiro;Kim,Mi-Sook;Lane,ScottWeston;Lok,David;Lublinsky,Anya;Mallender,William;McIntyre,Charles;Minissale,James;Mizutani,Hirotake;Mizutani,Miho;Molchinova,Nina;Ono,Koji;Patil,Ashok;Qian,Mark;Riceberg,Jessica;Shindi,Vaishali;Sintchak,MichaelD.;Song,Keli;Soucy,Teresa;Wang,Yana;Xu,He;Yang,Xiaofeng;Zawadzka,Agatha;Zhang,Ji;Pulukuri,SaiM.[JournalofMedicinalChemistry,2021,vol.64,#5,p.2501-2520]

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1Locationinpatent:Paragraph00997

Literature

Title: Sumoylation inhibitor TAK-981.

Title: TAK-981.

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Tags:1858276-04-6 Molecular Formula|1858276-04-6 MDL|1858276-04-6 SMILES|1858276-04-6 [(1R,2S,4R)-4-[[5-[[4-((1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthien-2-yl]carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate
Catalog No.: AA01KILM
1858276-04-6,MFCD32062692
1858276-04-6 | [(1R,2S,4R)-4-[[5-[[4-((1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthien-2-yl]carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate
Pack Size： 1mg
Purity： ≥98%
in stock
$98.00 $68.00
Pack Size： 5mg
Purity： ≥98%
in stock
$432.00 $302.00
Pack Size： 10mg
Purity： 98%
in stock
$644.00 $451.00
Pack Size： 25mg
Purity： ≥98%
in stock
$1,195.00 $836.00
Pack Size： 50mg
Purity： 98%
in stock
$1,398.00 $979.00
Pack Size： 100mg
Purity： 98%
in stock
$2,271.00 $1,590.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01KILM
Chemical Name: [(1R,2S,4R)-4-[[5-[[4-((1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthien-2-yl]carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate
CAS Number: 1858276-04-6
Molecular Formula: C25H28ClN5O5S2
Molecular Weight: 578.1033
MDL Number: MFCD32062692
SMILES: O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=C(C(C3=C[C@@]([C@@H]4NCCC5=C4C=C(Cl)C=C5)=C(C)S3)=O)C=NC=N2)C1)(N)=O
Properties
Downstream Synthesis Route
1858279-56-7    1858276-04-6 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[3]Langston,StevenP.;Grossman,Stephen;England,Dylan;Afroze,Roushan;Bence,Neil;Bowman,Douglas;Bump,Nancy;Chau,Ryan;Chuang,Bei-Ching;Claiborne,Christopher;Cohen,Larry;Connolly,Kelly;Duffey,Matthew;Durvasula,Nitya;Freeze,Scott;Gallery,Melissa;Galvin,Katherine;Gaulin,Jeffrey;Gershman,Rachel;Greenspan,Paul;Grieves,Jessica;Guo,Jianping;Gulavita,Nanda;Hailu,Shumet;He,Xingyue;Hoar,Kara;Hu,Yongbo;Hu,Zhigen;Ito,Mitsuhiro;Kim,Mi-Sook;Lane,ScottWeston;Lok,David;Lublinsky,Anya;Mallender,William;McIntyre,Charles;Minissale,James;Mizutani,Hirotake;Mizutani,Miho;Molchinova,Nina;Ono,Koji;Patil,Ashok;Qian,Mark;Riceberg,Jessica;Shindi,Vaishali;Sintchak,MichaelD.;Song,Keli;Soucy,Teresa;Wang,Yana;Xu,He;Yang,Xiaofeng;Zawadzka,Agatha;Zhang,Ji;Pulukuri,SaiM.[JournalofMedicinalChemistry,2021,vol.64,#5,p.2501-2520]

1858279-57-8    1858276-04-6 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[3]Langston,StevenP.;Grossman,Stephen;England,Dylan;Afroze,Roushan;Bence,Neil;Bowman,Douglas;Bump,Nancy;Chau,Ryan;Chuang,Bei-Ching;Claiborne,Christopher;Cohen,Larry;Connolly,Kelly;Duffey,Matthew;Durvasula,Nitya;Freeze,Scott;Gallery,Melissa;Galvin,Katherine;Gaulin,Jeffrey;Gershman,Rachel;Greenspan,Paul;Grieves,Jessica;Guo,Jianping;Gulavita,Nanda;Hailu,Shumet;He,Xingyue;Hoar,Kara;Hu,Yongbo;Hu,Zhigen;Ito,Mitsuhiro;Kim,Mi-Sook;Lane,ScottWeston;Lok,David;Lublinsky,Anya;Mallender,William;McIntyre,Charles;Minissale,James;Mizutani,Hirotake;Mizutani,Miho;Molchinova,Nina;Ono,Koji;Patil,Ashok;Qian,Mark;Riceberg,Jessica;Shindi,Vaishali;Sintchak,MichaelD.;Song,Keli;Soucy,Teresa;Wang,Yana;Xu,He;Yang,Xiaofeng;Zawadzka,Agatha;Zhang,Ji;Pulukuri,SaiM.[JournalofMedicinalChemistry,2021,vol.64,#5,p.2501-2520]

1858279-58-9    1858276-04-6 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[3]Langston,StevenP.;Grossman,Stephen;England,Dylan;Afroze,Roushan;Bence,Neil;Bowman,Douglas;Bump,Nancy;Chau,Ryan;Chuang,Bei-Ching;Claiborne,Christopher;Cohen,Larry;Connolly,Kelly;Duffey,Matthew;Durvasula,Nitya;Freeze,Scott;Gallery,Melissa;Galvin,Katherine;Gaulin,Jeffrey;Gershman,Rachel;Greenspan,Paul;Grieves,Jessica;Guo,Jianping;Gulavita,Nanda;Hailu,Shumet;He,Xingyue;Hoar,Kara;Hu,Yongbo;Hu,Zhigen;Ito,Mitsuhiro;Kim,Mi-Sook;Lane,ScottWeston;Lok,David;Lublinsky,Anya;Mallender,William;McIntyre,Charles;Minissale,James;Mizutani,Hirotake;Mizutani,Miho;Molchinova,Nina;Ono,Koji;Patil,Ashok;Qian,Mark;Riceberg,Jessica;Shindi,Vaishali;Sintchak,MichaelD.;Song,Keli;Soucy,Teresa;Wang,Yana;Xu,He;Yang,Xiaofeng;Zawadzka,Agatha;Zhang,Ji;Pulukuri,SaiM.[JournalofMedicinalChemistry,2021,vol.64,#5,p.2501-2520]

1858279-60-3    1858276-04-6 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1

[3]Langston,StevenP.;Grossman,Stephen;England,Dylan;Afroze,Roushan;Bence,Neil;Bowman,Douglas;Bump,Nancy;Chau,Ryan;Chuang,Bei-Ching;Claiborne,Christopher;Cohen,Larry;Connolly,Kelly;Duffey,Matthew;Durvasula,Nitya;Freeze,Scott;Gallery,Melissa;Galvin,Katherine;Gaulin,Jeffrey;Gershman,Rachel;Greenspan,Paul;Grieves,Jessica;Guo,Jianping;Gulavita,Nanda;Hailu,Shumet;He,Xingyue;Hoar,Kara;Hu,Yongbo;Hu,Zhigen;Ito,Mitsuhiro;Kim,Mi-Sook;Lane,ScottWeston;Lok,David;Lublinsky,Anya;Mallender,William;McIntyre,Charles;Minissale,James;Mizutani,Hirotake;Mizutani,Miho;Molchinova,Nina;Ono,Koji;Patil,Ashok;Qian,Mark;Riceberg,Jessica;Shindi,Vaishali;Sintchak,MichaelD.;Song,Keli;Soucy,Teresa;Wang,Yana;Xu,He;Yang,Xiaofeng;Zawadzka,Agatha;Zhang,Ji;Pulukuri,SaiM.[JournalofMedicinalChemistry,2021,vol.64,#5,p.2501-2520]

1858279-61-4    1858276-04-6 

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/4136,2016,A1Locationinpatent:Paragraph00997

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1396784-44-3
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Submit
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