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186392-43-8
Catalog No.:AA00ADAL

186392-43-8 | CP 316 819

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$175.00   $122.00
- +
10mg
99%
in stock  
$342.00   $240.00
- +
50mg
99%
in stock  
$1,217.00   $852.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ADAL
Chemical Name:
CP 316 819
CAS Number:
186392-43-8
Molecular Formula:
C21H22ClN3O4
Molecular Weight:
415.8701
SMILES:
CON(C(=O)[C@@H]([C@@H](NC(=O)c1cc2c([nH]1)ccc(c2)Cl)Cc1ccccc1)O)C
Properties
Properties
 
Form:
Solid  
MP:
190-192°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
572  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.2  

Literature

Title: Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model.

Journal: Neurochemistry international 20120201

Title: Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.

Journal: The Journal of pharmacology and experimental therapeutics 20110601

Title: Pharmacological manipulation of brain glycogenolysis as a therapeutic approach to cerebral ischemia.

Journal: Mini reviews in medicinal chemistry 20101001

Title: Functional significance of brain glycogen in sustaining glutamatergic neurotransmission.

Journal: Journal of neurochemistry 20090501

Title: The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug.

Journal: FEBS letters 20071002

Title: Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide).

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle.

Journal: Diabetes 20050801

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SDS
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Tags:186392-43-8 Molecular Formula|186392-43-8 MDL|186392-43-8 SMILES|186392-43-8 CP 316 819
Catalog No.: AA00ADAL
186392-43-8
186392-43-8 | CP 316 819
Pack Size： 1mg
Purity： ≥98%
in stock
$46.00 $32.00
Pack Size： 5mg
Purity： ≥98%
in stock
$175.00 $122.00
Pack Size： 10mg
Purity： 99%
in stock
$342.00 $240.00
Pack Size： 50mg
Purity： 99%
in stock
$1,217.00 $852.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00ADAL
Chemical Name: CP 316 819
CAS Number: 186392-43-8
Molecular Formula: C21H22ClN3O4
Molecular Weight: 415.8701
SMILES: CON(C(=O)[C@@H]([C@@H](NC(=O)c1cc2c([nH]1)ccc(c2)Cl)Cc1ccccc1)O)C
Properties
Form: Solid  
MP: 190-192°C  
Storage: -20 ℃;  
Complexity: 572  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.2  
Literature fold

Title: Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model.

Journal: Neurochemistry international20120201

Title: Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.

Journal: The Journal of pharmacology and experimental therapeutics20110601

Title: Pharmacological manipulation of brain glycogenolysis as a therapeutic approach to cerebral ischemia.

Journal: Mini reviews in medicinal chemistry20101001

Title: Functional significance of brain glycogen in sustaining glutamatergic neurotransmission.

Journal: Journal of neurochemistry20090501

Title: The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug.

Journal: FEBS letters20071002

Title: Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide).

Journal: The Journal of pharmacology and experimental therapeutics20070401

Title: Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle.

Journal: Diabetes20050801

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