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186392-40-5,MFCD00954145
Catalog No.:AA00ADGV

186392-40-5 | Cp-91149

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5mg
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10mg
≥98%
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$156.00   $109.00
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25mg
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$302.00   $211.00
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50mg
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100mg
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$852.00   $597.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ADGV
Chemical Name:
Cp-91149
CAS Number:
186392-40-5
Molecular Formula:
C21H22ClN3O3
Molecular Weight:
399.8707
MDL Number:
MFCD00954145
SMILES:
Clc1ccc2c(c1)cc([nH]2)C(=O)N[C@H]([C@H](C(=O)N(C)C)O)Cc1ccccc1
Properties
Computed Properties
 
Complexity:
553  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.2  

Literature

Title: Contributions of hepatic gluconeogenesis suppression and compensative glycogenolysis on the glucose-lowering effect of CS-917, a fructose 1,6-bisphosphatase inhibitor, in non-obese type 2 diabetes Goto-Kakizaki rats.

Journal: Journal of pharmacological sciences 20110101

Title: Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.

Journal: Diabetologia 20070801

Title: Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism.

Journal: Diabetes 20050301

Title: 5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.

Journal: Bioorganic & medicinal chemistry letters 20050117

Title: Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer.

Journal: BMC urology 20050101

Title: The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation.

Journal: The Journal of biological chemistry 20041105

Title: Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR). Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates.

Journal: The Journal of biological chemistry 20040326

Title: Regulation of glycogen metabolism in cultured human muscles by the glycogen phosphorylase inhibitor CP-91149.

Journal: The Biochemical journal 20040315

Title: Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression.

Journal: Biochemical and biophysical research communications 20030912

Title: Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis.

Journal: European journal of biochemistry 20030701

Title: Regulation of glycogen synthase by glucose and glycogen: a possible role for AMP-activated protein kinase.

Journal: Diabetes 20030101

Title: Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes.

Journal: The Biochemical journal 20021115

Title: Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.

Journal: The Journal of biological chemistry 20010629

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