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18711-12-1,MFCD03618551
Catalog No.:AA00ANBR

18711-12-1 | 6,7-Dichloroindoline-2,3-dione

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250mg
95%
2 weeks  
$125.00   $88.00
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1g
95%
2 weeks  
$193.00   $135.00
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5g
95%
2 weeks  
$770.00   $539.00
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10g
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$1,252.00   $877.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ANBR
Chemical Name:
6,7-Dichloroindoline-2,3-dione
CAS Number:
18711-12-1
Molecular Formula:
C8H3Cl2NO2
Molecular Weight:
216.0209
MDL Number:
MFCD03618551
SMILES:
O=C1C(=O)Nc2c1ccc(c2Cl)Cl
Properties
Computed Properties
 
Complexity:
269  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
XLogP3:
2  

Literature

Title: Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives.

Journal: British journal of pharmacology 20120501

Title: Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat.

Journal: The Journal of pharmacology and experimental therapeutics 20111201

Title: IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent.

Journal: Cell calcium 20111101

Title: KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.

Journal: Cell death & disease 20110401

Title: Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats.

Journal: Brain research 20100812

Title: Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles.

Journal: British journal of pharmacology 20100701

Title: Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries.

Journal: The Journal of pharmacology and experimental therapeutics 20100401

Title: Mechanisms underlying epithelium-dependent relaxation in rat bronchioles: analogy to EDHF-type relaxation in rat pulmonary arteries.

Journal: American journal of physiology. Lung cellular and molecular physiology 20100401

Title: Arterial stiffness is regulated by nitric oxide and endothelium-derived hyperpolarizing factor during changes in blood flow in humans.

Journal: Hypertension (Dallas, Tex. : 1979) 20100301

Title: NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats.

Journal: British journal of pharmacology 20100101

Title: Role of calcium-activated potassium channels with small conductance in bradykinin-induced vasodilation of porcine retinal arterioles.

Journal: Investigative ophthalmology & visual science 20090801

Title: Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090401

Title: TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels.

Journal: Journal of neurochemistry 20081101

Title: Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons.

Journal: Anesthesia and analgesia 20080901

Title: Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass.

Journal: Surgery 20080801

Title: Openers of calcium-activated potassium channels and endothelium-dependent hyperpolarizations in the guinea pig carotid artery.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080401

Title: Fluorescence-based Tl(+)-influx assays as a novel approach for characterization of small-conductance Ca(2+)-activated K (+) channel modulators.

Journal: Methods in molecular biology (Clifton, N.J.) 20080101

Title: Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SK(Ca) channels and caveolin-rich domains.

Journal: British journal of pharmacology 20070601

Title: Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Journal: Journal of medicinal chemistry 20070419

Title: Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.

Journal: Molecular pharmacology 20061101

Title: Urodynamic effects of intravesical administration of the new small/intermediate conductance calcium activated potassium channel activator NS309 in freely moving, conscious rats.

Journal: The Journal of urology 20060901

Title: Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

Journal: Biochimica et biophysica acta 20041011

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Tags:18711-12-1 Molecular Formula|18711-12-1 MDL|18711-12-1 SMILES|18711-12-1 6,7-Dichloroindoline-2,3-dione