Home Other Building Blocks 18711-16-5
18711-16-5,MFCD06798346
Catalog No.:AA00AQ9B

18711-16-5 | NS309

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5mg
≥98%
in stock  
$70.00   $49.00
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10mg
≥98%
in stock  
$98.00   $68.00
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50mg
≥98%
in stock  
$409.00   $286.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AQ9B
Chemical Name:
NS309
CAS Number:
18711-16-5
Molecular Formula:
C8H4Cl2N2O2
Molecular Weight:
231.0356
MDL Number:
MFCD06798346
SMILES:
ON=C1C(=O)Nc2c1ccc(c2Cl)Cl
Properties
Computed Properties
 
Complexity:
241  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
XLogP3:
3.2  

Literature

Title: Small conductance calcium-activated potassium channels: from structure to function.

Journal: Progress in neurobiology 20100701

Title: Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

Journal: British journal of pharmacology 20070701

Title: Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

Journal: The Journal of biological chemistry 20051216

Title: Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

Journal: Biochimica et biophysica acta 20041011

Title: Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

Title: C Hougaard, et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul; 151(5): 655–665.

Title: Nichole Coleman, et al. New Positive Ca2+-Activated K+ Channel Gating Modulators with Selectivity for KCa3.1. Mol Pharmacol. 2014 Sep; 86(3): 342–357.

Title: Dorte Strøbaek, et al. Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta. 2004 Oct 11;1665(1-2):1-5.

Title: Shankar P Parajuli, et al. NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels. Br J Pharmacol. 2013 Apr; 168(7): 1611–1625.

Title: Jie Zhu, et al. Activation of SK/KCa Channel Attenuates Spinal Cord Ischemia-Reperfusion Injury via Anti-oxidative Activity and Inhibition of Mitochondrial Dysfunction in Rabbits. Front Pharmacol. 2019; 10: 325.

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