[1]CurrentPatentAssignee:PFIZERINC-US4017606,1977,A
[1]CurrentPatentAssignee:PFIZERINC-US4017606,1977,A
[1]CurrentPatentAssignee:PFIZERINC-US4017606,1977,A
Title: Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo.
Journal: International journal of cancer 20120701
Title: Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine.
Journal: Blood 20120202
Title: Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels.
Journal: PloS one 20120101
Title: Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans--toxicological implications.
Journal: The Journal of toxicological sciences 20110801
Title: Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.
Journal: Cancer chemotherapy and pharmacology 20110201
Title: An APCI LC-MS/MS method for routine determination of capecitabine and its metabolites in human plasma.
Journal: Journal of mass spectrometry : JMS 20100601
Title: Stability of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in combination.
Journal: AAPS PharmSciTech 20100301
Title: Is the resistance of gemcitabine for pancreatic cancer settled only by overexpression of deoxycytidine kinase?
Journal: Oncology reports 20100201
Title: Synthesis of deoxytetrahydrouridine.
Journal: The Journal of organic chemistry 20090306
Title: Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice.
Journal: Cancer chemotherapy and pharmacology 20080801
Title: Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).
Journal: Cancer chemotherapy and pharmacology 20080701
Title: Optimized blood sampling with cytidine deaminase inhibitor for improved analysis of capecitabine metabolites.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080701
Title: Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080601
Title: Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: The 1.48 A resolution crystal structure of the homotetrameric cytidine deaminase from mouse.
Journal: Biochemistry 20060627
Title: Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide.
Journal: Chemical research in toxicology 20060101
Title: Structure of human cytidine deaminase bound to a potent inhibitor.
Journal: Journal of medicinal chemistry 20050210
Title: Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth.
Journal: Molecular microbiology 20031101
Title: Epimer interconversion, isomerization, and hydrolysis of tetrahydrouridine: implications for cytidine deaminase inhibition.
Journal: Journal of pharmaceutical sciences 20031001
Title: Analytical and pharmacokinetic studies with 5-chloro-2'-deoxycytidine.
Journal: Biochemical pharmacology 20021115
Title: Five-chlorodeoxycytidine, a tumor-selective enzyme-driven radiosensitizer, effectively controls five advanced human tumors in nude mice.
Journal: International journal of radiation oncology, biology, physics 20011101
Title: Regulatory effects of deoxyribonucleosides on the activity of 5-methoxymethyl-2'-deoxycytidine: modulation of antiherpes activity by deoxyguanosine and tetrahydrodeoxyuridine.
Journal: Antiviral research 19910501
Title: Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors.
Journal: Antiviral research 19900301
