Title: Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.
Journal: European journal of medicinal chemistry 20111201
Title: Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.
Journal: Biochimica et biophysica acta 20110801
Title: Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy.
Journal: Nephrology (Carlton, Vic.) 20110801
Title: Axonal neuregulin 1 type III activates NF-kappaB in Schwann cells during myelin formation.
Journal: The Journal of biological chemistry 20100528
Title: Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase.
Journal: Archives of dermatological research 20081001
Title: Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors.
Journal: Neoplasia (New York, N.Y.) 20080501
Title: Pharmacology of epidermal growth factor inhibitors.
Journal: The International journal of biological markers 20070101
Title: Tyrosine kinases: maiming myelin in leprosy.
Journal: Nature medicine 20060801
Title: ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli.
Journal: Nature medicine 20060801
Title: Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051001
Title: Antitumor activity of HER-2 inhibitors.
Journal: Cancer letters 20050908
Title: Epidermal growth factor inhibition in solid tumours.
Journal: Expert opinion on biological therapy 20050901
Title: Microanatomy of axon/glial signaling during Wallerian degeneration.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050330
Title: The epidermal growth factor receptor as a target for colorectal cancer therapy.
Journal: Seminars in oncology 20050201
Title: Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3'-deoxy-3'-18F-fluorothymidine PET.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050101
Title: Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041215
Title: Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade.
Journal: The Journal of pharmacology and experimental therapeutics 20041201
Title: Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation.
Journal: The Journal of biological chemistry 20041126
Title: Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20041101
Title: Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes.
Journal: Kidney international 20041101
Title: HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.
Journal: Cancer cell 20041101
Title: Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells.
Journal: The Journal of biological chemistry 20040827
Title: Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice.
Journal: Cancer research 20040615
Title: Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040401
Title: Novel radiosensitizers for locally advanced epithelial tumors: inhibition of the PI3K/Akt survival pathway in tumor cells and in tumor-associated endothelial cells as a novel treatment strategy?
Journal: International journal of radiation oncology, biology, physics 20040201
Title: Bioassay using epidermal keratinocytes to determine phosphorylation status of the epidermal growth factor receptor in distant neoplasms.
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Title: [Targeting of epidermal growth factor receptor and applications in ORL cancer].
Journal: Bulletin du cancer 20031101
Title: Renal cell carcinoma bone metastasis: epidermal growth factor receptor targeting.
Journal: Clinical orthopaedics and related research 20031001
Title: Clinical studies with non-iressa EGFR tyrosine kinase inhibitors.
Journal: Lung cancer (Amsterdam, Netherlands) 20030801
Title: Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030801
Title: Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.
Journal: Mechanisms of development 20030701
Title: Developing inhibitors of the epidermal growth factor receptor for cancer treatment.
Journal: Journal of the National Cancer Institute 20030618
Title: Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.
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Title: Tyrosine kinases as targets in cancer therapy - successes and failures.
Journal: Expert opinion on therapeutic targets 20030401
Title: Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude mice.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030301
Title: Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021101
Title: Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas.
Journal: The American journal of pathology 20020901
Title: The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides.
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Title: Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer.
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Title: HER-targeted tyrosine-kinase inhibitors.
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Title: Anticancer therapy targeting the erbB family of receptor tyrosine kinases.
Journal: Seminars in oncology 20011001
Title: Mammary glands reconstituted with Neu/ErbB2 transformed HC11 cells provide a novel orthotopic tumor model for testing anti-cancer agents.
Journal: Oncogene 20010906
Title: Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010801
