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187735-94-0,MFCD09970763
Catalog No.:AA00AKOU

187735-94-0 | BIO 1211

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
1 week  
$187.00   $131.00
- +
2mg
1 week  
$250.00   $175.00
- +
5mg
1 week  
$388.00   $272.00
- +
10mg
1 week  
$587.00   $411.00
- +
25mg
1 week  
$912.00   $639.00
- +
50mg
1 week  
$1,186.00   $830.00
- +
100mg
1 week  
$1,635.00   $1,144.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AKOU
Chemical Name:
BIO 1211
CAS Number:
187735-94-0
Molecular Formula:
C36H48N6O9
Molecular Weight:
708.8011
MDL Number:
MFCD09970763
SMILES:
CC(C[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C(C)C)CC(=O)O)NC(=O)Cc1ccc(cc1)NC(=O)Nc1ccccc1C)C
Properties
Computed Properties
 
Complexity:
1250  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
51  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
16  
XLogP3:
3  

Literature

Title: [Inhibitory effects of BIO-1211 on bronchoconstriction and neutrophil adhesion in rats].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20080701

Title: Effect of enalapril on the in vitro and in vivo peptidyl cleavage of a potent VLA-4 antagonist.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070501

Title: Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging.

Journal: Nature chemical biology 20060701

Title: The effects of 1-month administration of asoprisnil (J867), a selective progesterone receptor modulator, in healthy premenopausal women.

Journal: Human reproduction (Oxford, England) 20050401

Title: Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.

Journal: Bioorganic & medicinal chemistry letters 20050103

Title: Studies on the internalization mechanism of cationic cell-penetrating peptides.

Journal: The Journal of biological chemistry 20030815

Title: The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20011022

Title: Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.

Journal: Journal of medicinal chemistry 19990311

Title: L L Chen, et al. Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand. J Biol Chem. 1999 May 7;274(19):13167-75.

Title: Nourollah Ramroodi, et al. Prophylactic Effect of BIO-1211 Small-Molecule Antagonist of VLA-4 in the EAE Mouse Model of Multiple Sclerosis. Immunol Invest. 2015;44(7):694-712.

Title: K c Lin, et al. Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. J Med Chem. 1999 Mar 11;42(5):920-34.

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