Title: Traxoprodil decreases pentylenetetrazol-induced seizures.
Journal: Epilepsy research 20120601
Title: Behavioral deficits and cellular damage following developmental ethanol exposure in rats are attenuated by CP-101,606, an NMDAR antagonist with unique NR2B specificity.
Journal: Pharmacology, biochemistry, and behavior 20120101
Title: Nonselective and NR2B-selective N-methyl-D-aspartic acid receptor antagonists produce antinociception and long-term relief of allodynia in acute and neuropathic pain.
Journal: Anesthesiology 20110701
Title: Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses.
Journal: The Journal of biological chemistry 20110304
Title: Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease.
Journal: Experimental neurology 20101001
Title: Forelimb dyskinesia mediated by high-frequency stimulation of the subthalamic nucleus is linked to rapid activation of the NR2B subunit of N-methyl-D-aspartate receptors.
Journal: The European journal of neuroscience 20100801
Title: Comments on 'An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606 in patients with treatment-refractory major depressive disorder'.
Journal: Journal of clinical psychopharmacology 20090801
Title: An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.
Journal: Journal of clinical psychopharmacology 20081201
Title: Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and Parkinsonism.
Journal: Movement disorders : official journal of the Movement Disorder Society 20081015
Title: Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test.
Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20080201
Title: The phencyclidine-like discriminative stimulus effects and reinforcing properties of the NR2B-selective N-methyl-D-aspartate antagonist CP-101 606 in rats and rhesus monkeys.
Journal: Behavioural pharmacology 20071201
Title: Metabolism, distribution and excretion of a selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in rats and dogs.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801
Title: Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors.
Journal: Nitric oxide : biology and chemistry 20070801
Title: Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine.
Journal: The Journal of pharmacology and experimental therapeutics 20070501
Title: NR2B subunit exerts a critical role in postischemic synaptic plasticity.
Journal: Stroke 20060701
Title: Glutamate-based therapeutic approaches: NR2B receptor antagonists.
Journal: Current opinion in pharmacology 20060201
Title: Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers.
Journal: Clinical pharmacokinetics 20060101
Title: The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury.
Journal: Journal of neurotrauma 20051201
Title: Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.
Journal: The European journal of neuroscience 20050901
Title: Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050720
Title: Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat.
Journal: Psychopharmacology 20050401
Title: NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.
Journal: Current drug targets. CNS and neurological disorders 20050401
Title: Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model.
Journal: Pharmacology 20050101
Title: Characterization of N-methyl-D-aspartate receptor subunits responsible for postoperative pain.
Journal: European journal of pharmacology 20041025
Title: NR2B selective NMDA receptor antagonist CP-101,606 prevents levodopa-induced motor response alterations in hemi-parkinsonian rats.
Journal: Neuropharmacology 20040801
Title: The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease.
Journal: Experimental neurology 20040801
Title: Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol.
Journal: Brain research 20040611
Title: Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains.
Journal: Biological & pharmaceutical bulletin 20040401
Title: The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies.
Journal: Current medicinal chemistry 20040201
Title: Characterization of N-methyl-D-aspartate receptor subunits involved in acute ammonia toxicity.
Journal: Neurochemistry international 20040101
Title: The NMDA NR2B subunit-selective receptor antagonist, CP-101,606, enhances the functional recovery the NMDA NR2B subunit-selective receptor and reduces brain damage after cortical compression-induced brain ischemia.
Journal: Journal of neurotrauma 20040101
Title: Antioxidant-accelerated oxidative degradation: a case study of transition metal ion catalyzed oxidation in formulation.
Journal: Pharmaceutical development and technology 20040101
Title: The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze.
Journal: European journal of pharmacology 20030829
Title: Reduced brain infarct volume and improved neurological outcome by inhibition of the NR2B subunit of NMDA receptors by using CP101,606-27 alone and in combination with rt-PA in a thromboembolic stroke model in rats.
Journal: Journal of neurosurgery 20030201
Title: Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Journal: Neurochemistry international 20030101
Title: Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors.
Journal: Nuclear medicine and biology 20020701
Title: Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists.
Journal: Neuropharmacology 20020301
