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188791-09-5,MFCD07363998
Catalog No.:AA01E3FI

188791-09-5 | JTE607Dihydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$128.00   $89.00
- +
10mg
≥98%
in stock  
$203.00   $142.00
- +
100mg
98%
in stock  
$368.00   $258.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01E3FI
Chemical Name:
JTE607Dihydrochloride
CAS Number:
188791-09-5
Molecular Formula:
C25H33Cl4N3O5
Molecular Weight:
597.3586
MDL Number:
MFCD07363998
SMILES:
CCOC(=O)[C@@H](NC(=O)c1cc(Cl)c(c(c1O)Cl)OCCN1CCN(CC1)C)Cc1ccccc1.Cl.Cl
Properties
Computed Properties
 
Complexity:
674  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
11  

Downstream Synthesis Route
Literature

Title: Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers.

Journal: International immunopharmacology 20111101

Title: JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.

Journal: Cancer science 20100301

Title: JTE-607, an inflammatory cytokine synthesis inhibitor, attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats.

Journal: Journal of bioscience and bioengineering 20080701

Title: JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model.

Journal: Experimental hematology 20061001

Title: Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride] in a mouse septic shock model.

Journal: The Journal of pharmacology and experimental therapeutics 20041201

Title: Pharmacologic preconditioning of JTE-607, a novel cytokine inhibitor, attenuates ischemia-reperfusion injury in the myocardium.

Journal: The Journal of thoracic and cardiovascular surgery 20040601

Title: JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats.

Journal: European journal of pharmacology 20040319

Title: Prior burn insult induces lethal acute lung injury in endotoxemic mice: effects of cytokine inhibition.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030201

Title: Prophylactic effect of JTE-607 on LPS-induced acute lung injury in rats with CINC-1 inhibition.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020301

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