Home Other Building Blocks 189224-48-4
189224-48-4,MFCD01861185
Catalog No.:AA002I10

189224-48-4 | KU14R

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$138.00   $97.00
- +
10mg
98%
in stock  
$181.00   $127.00
- +
25mg
98%
in stock  
$332.00   $233.00
- +
50mg
98%
in stock  
$579.00   $405.00
- +
100mg
98%
in stock  
$995.00   $697.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002I10
Chemical Name:
KU14R
CAS Number:
189224-48-4
Molecular Formula:
C13H14N2O
Molecular Weight:
214.2631
MDL Number:
MFCD01861185
SMILES:
CCC1(Cc2c(O1)cccc2)c1ncc[nH]1
Properties
Computed Properties
 
Complexity:
258  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.3  

Literature

Title: Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R.

Journal: Diabetologia 20051201

Title: Evidence for nonadrenoceptor responses to imidazoline derivatives in the porcine isolated rectal artery.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse.

Journal: European journal of pharmacology 20021101

Title: Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery.

Journal: British journal of pharmacology 20010401

Title: Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.

Journal: Diabetes 20010201

Title: Bozdagi O, Wang XB, Martinelli GP, et al. Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors. J Neurophysiol. 2011,105(3):1266-75.

Title: Bleck C, Wienbergen A, Rustenbeck I. Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. Diabetologia. 2005 Dec;48(12):2567-75.

Title: Cooper EJ, Hudson AL, Parker CA, et al. Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol. 2003;482(1-3):189-96.

Title: Mayer G, Taberner PV. Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. Eur J Pharmacol. 2002;454(1):95-102.

Title: Susan L.F Chana, Anna L Palletta, John Clewsb. Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with σ receptors. European Journal of Pharmacology. 1997,323( 2-3): 241-244.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 189224-48-4
Tags:189224-48-4 Molecular Formula|189224-48-4 MDL|189224-48-4 SMILES|189224-48-4 KU14R