+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Amines 189349-50-6
189349-50-6,MFCD11045931
Catalog No.:AA002I9Z

189349-50-6 | 1-Piperazinecarboxylic acid, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2-[[(1,1-dimethylethyl)amino]carbonyl]-, phenylmethyl ester, (2S)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$37.00   $26.00
- +
5mg
97%
in stock  
$64.00   $45.00
- +
10mg
97%
in stock  
$111.00   $78.00
- +
25mg
97%
in stock  
$184.00   $129.00
- +
50mg
97%
in stock  
$311.00   $218.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002I9Z
Chemical Name:
1-Piperazinecarboxylic acid, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2-[[(1,1-dimethylethyl)amino]carbonyl]-, phenylmethyl ester, (2S)-
CAS Number:
189349-50-6
Molecular Formula:
C27H34N6O5
Molecular Weight:
522.5961
MDL Number:
MFCD11045931
SMILES:
COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1
Properties

Downstream Synthesis Route

[1]Patane,MichaelA.;Scott,AnnL.;Broten,TheodoreP.;Chang,RaymondS.L.;Ransom,RichardW.;DiSalvo,Jerry;Forray,Carlos;Bock,MarkG.[JournalofMedicinalChemistry,1998,vol.41,#8,p.1205-1208]

[2]CurrentPatentAssignee:MERCK&COINC-US5747490,1998,A

[1]Patane,MichaelA.;Scott,AnnL.;Broten,TheodoreP.;Chang,RaymondS.L.;Ransom,RichardW.;DiSalvo,Jerry;Forray,Carlos;Bock,MarkG.[JournalofMedicinalChemistry,1998,vol.41,#8,p.1205-1208]

[2]CurrentPatentAssignee:MERCK&COINC-US5747490,1998,A

[1]Patane,MichaelA.;Scott,AnnL.;Broten,TheodoreP.;Chang,RaymondS.L.;Ransom,RichardW.;DiSalvo,Jerry;Forray,Carlos;Bock,MarkG.[JournalofMedicinalChemistry,1998,vol.41,#8,p.1205-1208]

[1]Patane,MichaelA.;Scott,AnnL.;Broten,TheodoreP.;Chang,RaymondS.L.;Ransom,RichardW.;DiSalvo,Jerry;Forray,Carlos;Bock,MarkG.[JournalofMedicinalChemistry,1998,vol.41,#8,p.1205-1208]

[1]Patane,MichaelA.;Scott,AnnL.;Broten,TheodoreP.;Chang,RaymondS.L.;Ransom,RichardW.;DiSalvo,Jerry;Forray,Carlos;Bock,MarkG.[JournalofMedicinalChemistry,1998,vol.41,#8,p.1205-1208]

Literature

Title: Patane MA, et al. 4-Amino-2---(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)aminocarbonyl-piperazinyl-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist. J Med Chem. 1998 Apr 9;41(8):1205-8.

Title: Tobias Böhmer, et al. The α1B-adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium. Br J Pharmacol. 2014 Aug; 171(16): 3858–3867.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 189349-50-6
Building Blocks
More >
Tags:189349-50-6 Molecular Formula|189349-50-6 MDL|189349-50-6 SMILES|189349-50-6 1-Piperazinecarboxylic acid, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2-[[(1,1-dimethylethyl)amino]carbonyl]-, phenylmethyl ester, (2S)-